Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
🎉 Included in our Top 100 Downloaded Articles in 2022 Collection. Explore 'Targeting Solid Tumors with Bispecific T Cell Engager Immune Therapy' by Angela Coxon et al., either #OpenAccess or freely available to download through the collection https://arevie.ws/3X2aL6f
"Big Pharma involvement in IL-12 is fading fast. Days after Bristol Myers Squibb punted its IL-12 fusion protein, AstraZeneca has jettisoned a gene therapy to dial down its interest in the cytokine for the second time in as many quarters."
Thiago Carvalho
boosted
Interesting commentary this. Bottom line, #vaccine effectiveness is not all in the antibody titre.
Co-administration of #COVID19 & #influenza #vaccines may increase uptake of both and still both be as clinically effective as when given apart.
"Co-administration of COVID-19 and influenza vaccines" - Clinical Microbiology and Infection #IDMastodon #MedMastodon
"We wanted to understand how goblet cells control the amount of mucus they secrete and why autophagy is needed for proper goblet cell function. Here, we show that autophagy relieves ER stress in goblet cells to facilitate mucus secretion."
#Immunology #MucosalImmunology #GobletCells #autophagy
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00031-8
Thiago Carvalho
boosted
In our recent "Inversion Invasions" paper we studied the conditions under which inversions invade genomes and become involved in adaptation. We found that inversions were more likely to be involved in adaptation when the genetic basis of the adaptive trait was highly polygenic. #EvolgenPaper #EvolutionPaper #PopulationGenetics @royalsociety https://royalsocietypublishing.org/doi/10.1098/rstb.2021.0200 We developed this plot to visualize how inversions capture and gain genetic variation through time.
Thiago Carvalho
boosted
Sagy et al. have recently published in #NatureMedicine an analysis of the real-world efficacy of #JYNNEOS, the #smallpox shot redeployed against #monkeypox.
https://www.nature.com/articles/s41591-023-02229-3
Last Fall I wrote a column for Nature Medicine that touched on the FDA's Animal Rule, used in the approval of anti-smallpox drugs due to the difficulty in designing ethically acceptable efficacy screens.
Thiago Carvalho
boosted
Did you miss the Recognizing Preprint Peer Review event?
You can still view the recordings, listen to discussions about citing #preprints with reviews, and watch presentations from @EuropePMC, @scietyHQ, @COAR_eV about preprint #PeerReview, and more!
https://buff.ly/3GwhH5D
Thiago Carvalho
boosted
Meanwhile in Florida, they're arresting 11-year-olds for not standing for the pledge of allegiance. Something something something free speech. https://www.baynews9.com/fl/tampa/news/2019/02/14/mother-upset-after-son-kicked-out-of-class-over-pledge-of-allegiance
"As the anthropologist Joseph Masco put it, through these simulations the government ‘sought to make mass death an intimate psychological experience while simultaneously claiming that thermonuclear war could be planned for alongside tornados, floods, and traffic accidents.’"
https://aeon.co/essays/how-atomic-doomsday-experiments-shaped-disturbance-ecology
Thiago Carvalho
boosted
Postdoctoral Fellow @DrJ_RNA
I've got four letters for you: RNA
Join the Jonesy Lab at NYU to study how RNA structure is modulated by protein binding. #RNA #protein #NMR #cryoEM
https://jobrxiv.org/job/new-york-university-27778-postdoctoral-fellow-2/?feed_id=37886
#ScienceJobs #job #RNA #NMR
New York #Unite...
https://jobrxiv.org/job/new-york-university-27778-postdoctoral-fellow-2/?feed_id=37886
Thiago Carvalho
boosted
Nice piece: “Stop the peer-review treadmill: I want to get off”. I think the days of pre-publication peer review are already numbered. To maintain it there needs to be better incentives - and I don’t mean payment! Recognition of peer review activity as a scholarly contribution would help a lot.
'But for all the ground that’s been gained, the road ahead is arduous. Long COVID still lacks a universal clinical definition and a standard diagnosis protocol; there’s no consensus on its prevalence, or even what symptoms fall under its purview.'
Thiago Carvalho
boosted
In China there is a legend that if a carp is strong enough to swim upstream against strong currents, it can become a dragon.
#SwampSunday #ukiyoe #folklore #JapaneseArt @folklore
🎨'Carp' from an untitled series known as 'Large Fish' - Utagawa Hiroshige, 1842.
"Here, we have identified a population of innate lymphocytes that we term tissue-resident memory-like natural killer (NKRM) cells. In response to murine cytomegalovirus infection, we show that circulating NK cells were recruited in a CX3CR1-dependent manner to the salivary glands where they formed NKRM cells, a long-lived, tissue-resident population that prevented autoimmunity via TRAIL-dependent elimination of CD4+ T cells."
Schuster et al @ImmunityCP
#Immunology #NKCells #ImmuneRegulation
https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2
Thiago Carvalho
boosted
Rising seas threaten ‘mass exodus on a biblical scale’, UN chief warns
António Guterres calls for urgent action as climate-driven rise brings ‘torrent of trouble’ to almost a billion people
#ClimateEmergency #pollution #ecology #environment #ClimateCrisis #ClimateCatastrophe
#ClimateChange #Climate
"This systematic uncertainty in career prospects further tips the scale against researchers from underrepresented groups7, those who are less able to flexibly respond to emerging career opportunities (for example, through geographical relocation or by working overtime) and potentially even those who prioritize research quality over their personal employability."
"FENS travel grants are avialble travel grants to support young investigators, PhD or MSc students attending the 46th Annual Meeting of Japan Neuroscience Society: Towards the Galaxy of Neuroscience (Sendai International Center, Aoba-ku, Japan, 1-4 August 2023)."
What a heartbreaking novel. I saw Kasdan's film version in the 80s, a very good movie with one of the all time best siblings castings (William Hurt, Kathleen Turner, Ed Begley Jr & David Ogden Stiers).
But Tyler's book is even better.
Thiago Carvalho
boosted
"Transient receptor potential vanilloid 1 (TRPV1), a receptor for capsaicin and noxious heat, has been one of the most compelling targets for analgesics. However, systemic inhibition of TRPV1 is an impractical approach as a pain killer, since systemic antagonism induces hyperthermia. Two articles in this issue of the JCI report phenotypes from separate, rare missense mutations of human TRPV1."
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
