Thiago Carvalho @cyrilpedia@qoto.org

@lmrocha Thanks Luis

Merck makes a big bet in autoimmunity:

"Aqilion has persuaded Merck its preclinical project can overcome the barriers. The biotech has created selective TAK1 inhibitors with applications in autoimmune and inflammatory diseases."

https://www.fiercebiotech.com/biotech/merck-kgaa-spying-major-market-pays-aqilion-eu10m-tackle-tough-autoimmune-target

'Studying the art of people with a range of brain injuries can lend insights into “the different ways the brain engages in creative activity,” King says. Use of color, realism versus abstraction, and changes in other formal elements over time can hint at the deterioration of specific brain structures, she says.'

https://www.pnas.org/doi/10.1073/pnas.2221843120

"It is often assumed that generic drugs are affordable and widely available to those who need them. But this is not entirely true. For example, even after patent expiries open the door to generic rivals, low levels of competition between companies in smaller markets means that generics can actually be more expensive in poor countries than in wealthy ones."

https://www.ft.com/content/99d64932-fd04-488f-9c63-b3646083cbbc

@cyrus You can get a lot done on a manilla A3

'Marty once said of Dave, “I was lucky to get him. We taught him how to grow Tetrahymena, and he taught us a lot about how to do science.”'

https://www.cell.com/cell/fulltext/S0092-8674(23)00089-2

'I remember, many years ago, sitting mystified through a seminar where the leading lights of English philosophy gathered in Oxford to discuss John Rawls’s newly published Theory of Justice. There was radical disagreement as to what Rawls meant to say. The answer seemed to me (a young Skinnerian) obvious: why not phone him up and ask him?'

https://thecritic.co.uk/issues/february-2023/the-enlightenment-as-reading-project/

Print by Madalena Parreira & Constança Arouca

“Map 10 The Turbulence Chart (Lviv, Ukraine, circa 1890)

This engraving was part of a set that illustrated the fabled, never published, “Order & Disorder” manuscript by Bronislaw Zamoyski (sometimes referred to as the “Leibniz of Lviv”). The text and all accompanying illustrations were thought to have been lost when the Russian Army captured Lviv in 1914. How it was obtained by von Willebrand remains unknown.”

https://madalenaparreira.com/SPAM

The NIH is requesting input on postdoc career structure and funding (Closing date in April 14th).

https://grants.nih.gov/grants/guide/notice-files/NOT-OD-23-084.html

Well played

"Despite the multifactorial pathogenesis, available data show that long COVID is an organic post-acute infection syndrome (PAIS) with clear physiological dysfunction that is often not consistently apparent using standard medical diagnostic tests."

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00053-1/fulltext?s=09