Thiago Carvalho @cyrilpedia@qoto.org

'We find the canonical Wnt pathway to be activated in mesenchymal progenitors (MPs) from cancer-induced cachectic mouse muscle. Next, we induce β-catenin transcriptional activity in murine MPs. As a result, we observe expansion of MPs in the absence of tissue damage, as well as rapid loss of muscle mass.'

https://www.cell.com/developmental-cell/fulltext/S1534-5807(23)00051-5

'aken together, these two books advance a wealth of arguments that historians of science have been making for decades, and they ask us to reevaluate the uses, often violent and exclusionary, to which science and the history of science have been put.'

https://www.bostonreview.net/articles/how-not-to-tell-the-history-of-science/

@tsubtext Thanks for sharing that

"It might seem that the obvious course is not to make multiple models but rather to grow a network. Instead of developing two networks for recognizing cats and horses respectively, for instance, it might appear easier to teach the cat-savvy network to also recognize horses. This approach, however, forces AI designers to confront one of the main issues in lifelong learning, a phenomenon known as catastrophic forgetting. A network trained to recognize cats will develop a set of weights across its artificial neurons that are specific to that task. If it is then asked to start identifying horses, it will start readjusting the weights to make it more accurate for horses. The model will no longer contain the right weights for cats, causing it to essentially forget what a cat looks like. “The memory is in the weights. When you train it with new information, you write on the same weights,” says Siegelmann"

https://www.nature.com/articles/d41586-022-01962-y

Currently listening to: Tokyo funk sessions 2022

https://www.youtube.com/watch?v=nQufZEijRmc

"Our data provide a model where the global shutdown of protein synthesis and subsequent rebooting mediated by miR-10b-5p downregulation is a hallmark of the dedifferentiation stage of limb regeneration."

https://www.cell.com/developmental-cell/fulltext/S1534-5807(23)00049-7?rss=yes&utm_source=dlvr.it&utm_medium=twitter

@enirenberg There are many forms of autoreactivity that are part of healthy physiology - from housekeeping natural abs to regulatory T cells.

Margaret Atwood's epiphany (fm her book On Writers and Writing).

Phage for lunch

"Highly purified T4 phages were rapidly internalized by mammalian cells and accumulated within macropinosomes but did not activate the inflammatory DNA response TLR9 or cGAS-STING pathways."
#Preprint #Phage

https://www.biorxiv.org/content/10.1101/2023.03.10.532157v1

"Perhaps this is as it should be: if Rupert Murdoch’s Wall Street Journal were going to embrace Free Market’s message enthusiastically, Soll would have had no reason to write the book."

https://lareviewofbooks.org/article/how-we-learned-to-love-free-markets/

Drug development sets its sights on ADAR

'RNA editing is rapidly gaining prominence as its transient and reversible changes promise a safer and more flexible option to reverse disease-causing mutations than DNA editing.'

https://www.nature.com/articles/s41587-023-01709-8