Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Another illustration by Madalena Parreira for the online content I created while at JEM - Dan Davis.
At the time, Davis had just published The Compatibility Gene - the lottery motif alludes to matching MHC types for transplantation. A common theme for this interview and the interview with Matt Cobb (https://flexnersuitcase.wordpress.com/2015/08/17/the-first-five-pages-a-conversation-with-matthew-cobb/) was how scientists find a publisher when they have a book project
https://flexnersuitcase.wordpress.com/2015/09/14/finding-stories-a-conversation-with-dan-davis/
PI call at Institut de Génomique Fonctionnelle de Lyon (IGFL)
'We have an opening for an independent group leader (junior or established). Talented scientists leading research falling within the scientific scope of the Institute are encouraged to apply. We are seeking to increase the number of women team leaders and will particularly welcome applications from women scientists.'
Thiago Carvalho
boosted
RT @PLOS
Bumblebees can solve puzzles by copying others, suggesting insects might have culture, find @alicedbridges of @QMUL and colleagues. #bee
🔎 @PLOSBiology paper: https://plos.io/3ZNVpTP
📰 @NPR article: https://plos.io/3l4dGh2
📰 @abc_ciencia article: https://plos.io/3JulZft
Editor position open at FEBS
"Editor, Molecular Oncology
FEBS seeks a full-time Editor to join the editorial team of the open access journal Molecular Oncology."
Thiago Carvalho
boosted
In the most recent episode of the Epigenetics Podcast, we caught up with Sarah Kimmins from Université de Montreal to talk about her work on the epigenetics of human #sperm cells. #epigenetics #podcast #chromatin #WomenInSTEM @epigenetics
Listen here: https://activemotif.com/podcasts#sarah-kimmins
Tools
"RNA structural switches are key regulators of gene expression in bacteria, yet their characterization in Metazoa remains limited. Here we present SwitchSeeker, a comprehensive computational and experimental approach for systematic identification of functional RNA structural switches."
#preprint
Thiago Carvalho
boosted
The labs of Jan-Michael Peters and @leonidmirny @MIT have found how #genetranscription interferes with #cohesin-mediated loop extrusion. Transcription shapes genome organisation in unexpected ways!
The paper: https://www.pnas.org/doi/10.1073/pnas.2210480120
Our news article: https://www.imp.ac.at/news/article/gene-transcription-hampers-cohesins-travel-along-chromosomes
'Multistep IgE mast cell desensitization is a dose- and time-regulated process that blocks β-hexosaminidase, impacting membrane and cytoskeletal movements. Signal transduction is uncoupled, favoring early phosphorylation of SHIP-1. Silencing SHIP-1 impairs desensitization without implicating its phosphatase function'
Thiago Carvalho
boosted
Unraveling dynamically-encoded latent transcriptomic patterns in pancreatic cancer cells by topic modelling https://www.biorxiv.org/content/10.1101/2023.03.11.532182v1?med=mas
Thiago Carvalho
boosted
📢Interested in tips for writing scientific papers 🤔?
Well, we got you covered with this episode😉!
#phdlife #phdchat #xp #AcademicChatter #phdvoice #AcademicTwitter#phdlife #phdchat #xp #AcademicChatter #phdvoice #AcademicTwitter
'Led by industry groups like the National Association of Manufacturers and the National Electric Light Association, business leaders fought child-labor laws and workmen’s compensation as unfair limits on companies while insisting that “anything less than total business freedom was a step on the road to socialism, or worse.”
https://www.washingtonpost.com/books/2023/03/10/big-myth-business-oreskes-conway/
'As horrible as Covid has been — it remains one of the leading causes of death in the United States — it is not the worst-case scenario. There are viruses with case fatality rates twice, 10 times or even greater than that of Covid, such as H5N1 influenza (bird flu), Nipah and Ebola.'
https://www.nytimes.com/2023/03/12/opinion/pandemic-health-prepare.html
Thiago Carvalho
boosted
"It might seem that the obvious course is not to make multiple models but rather to grow a network. Instead of developing two networks for recognizing cats and horses respectively, for instance, it might appear easier to teach the cat-savvy network to also recognize horses. This approach, however, forces AI designers to confront one of the main issues in lifelong learning, a phenomenon known as catastrophic forgetting. A network trained to recognize cats will develop a set of weights across its artificial neurons that are specific to that task. If it is then asked to start identifying horses, it will start readjusting the weights to make it more accurate for horses. The model will no longer contain the right weights for cats, causing it to essentially forget what a cat looks like. “The memory is in the weights. When you train it with new information, you write on the same weights,” says Siegelmann"
'The evolution of the larva, though, altered brain development to make a modified, simpler brain appropriate for the sensory and motor demands of the larva. This larval brain, though, is not discarded at the end of larval growth and a new one made from scratch. Most larval neurons persist and some, like the interneurons mediating backwards locomotion, have similar functions in both larva and adult (Lee and Doe, 2021), but, as we show in this paper, the maintenance of neuronal function from larva to adult is not always the case.'
Thiago Carvalho
boosted
@eLife Few things scream “James W. Truman” as insect metamorphosis and in particular neural fate from embryo to larva, pupa, and adult #Drosophila. The above is a lovely insight piece from Andi Thum and Bertram Gerber.
Jim’s paper: https://elifesciences.org/articles/80594
#neuroscience #metamorphosis
Thiago Carvalho
boosted
“As a recruiter, he has noticed that men now regularly ask about flexibility. A recent client told him that his priority was meeting his child at the bus at 3:30 p.m., and that he’d give up pay to do that.
“‘You would never have heard that out of anybody’s mouth,” he said. “Never. And now it’s commonplace. It’s not a sign of weakness anymore.’”
https://www.nytimes.com/2023/03/12/upshot/fathers-pandemic-remote-work.html?smid=nytcore-ios-share&referringSource=articleShare
Thiago Carvalho
boosted
Tim Berners-Lee proposed a hypertext system that would sit atop the internet #OTD in 1989, and now we all live in it.
Happy 34th birthday to [sweeps arm in a grand gesture, revealing this Hieronymus Bosch tableau of the damned all around us] the Web.
Image: Tim Berners-Lee / CERN
'Artificial intelligence is a loose term, and I mean it loosely. I am describing not the soul of intelligence, but the texture of a world populated by ChatGPT-like programs that feel to us as though they were intelligent, and that shape or govern much of our lives. Such systems are, to a large extent, already here. But what’s coming will make them look like toys. What is hardest to appreciate in A.I. is the improvement curve.'
https://www.nytimes.com/2023/03/12/opinion/chatbots-artificial-intelligence-future-weirdness.html
A conversation I had with @marcellaflamme from @PLOS about #preprints, #peerreview, AI, and, of course, #ReviewCommons has just been posted on the RC site.
"Q As we ask peer review to do more and more things, should we also be looking at new ways to recognize the work of reviewers?
LaFlamme: Another way to ask that question is: should outputs other than published articles and big grants count toward research assessment and the development of scientific careers?"
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
