Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Researchers need guidance on what is meant by "the data" and on where they should archive datasets.
This letter is a call for some joined-up thinking: https://rdcu.be/c6ZWh
Scientists in various fields have expressed confusion to me about what to archive and where in light of recent mandates. If the point of data deposits is reuse not just compliance in the event someone ever has a problem with the paper, they need more guidance.
"The EU has ordered Illumina to divest Grail and is expected to issue a fine of up to 10 per cent of its annual revenue in the coming weeks for closing the deal without securing regulatory approval. Illumina is running Grail as a subsidiary while it battles the EU order."
https://www.ft.com/content/653c4d1c-d5cf-406c-b2e8-fa24ee453153
Thiago Carvalho
boosted
Nicola L. Stevenson et al. complete a future leader #review of the well-studied interactions between the #Golgi, #cilium and #extra cellular matrix, with a particular focus on how the interplay between all three compartments underpins healthy tissue.
https://journals.biologists.com/bio/article/12/2/bio059719/287059/The-factory-the-antenna-and-the-scaffold-the-three#Biology
#Science #BiologyOpen #AcademicMastodon
Thiago Carvalho
boosted
75% of scientists are burned out and pulling back on conferences, peer review, committee membership, etc https://www.nature.com/articles/d41586-023-00633-w
When scientists set boundaries, it not only improves their own personal well-being, but also creates norms that limits are acceptable and healthy
Thiago Carvalho
boosted
Study shows that morphogens in #Drosophila blastoderm control formation of cell densities along the #DVaxis that in turn is necessary for fine-tuning #morphogen gradient levels; #frazzled & #GUKholder are key effectors in this process #PLOSBiology https://plos.io/3YKufMO
'A big reason people don’t stay in public health is money. Salaries are small. Bureaucracies are large. Since the pandemic, abuse has also been on the rise. And in more than half the states, lawmakers have curtailed public health experts’ ability to make and carry out policies. Castrucci said that’s like using a jackhammer to shatter our own collective safety.'
'Here, Thacker et al. demonstrated that Socs3highCD11b–CD27– immature NK cells were present in samples from patients with triple negative breast cancer (TNBC) and correlated with worse prognosis. The authors further showed that this population of NK cells promoted, rather than inhibited, tumor progression in mice.'
#BreastCancer #NaturalKillerCells #NKcells
https://www.science.org/doi/10.1126/scitranslmed.abl4414#sec-2
'Unequal access to Covid-19 vaccines in 2021 led to one preventable death every 24 seconds, according to an open letter signed by prominent political figures, activists and academics that marks the third anniversary since the World Health Organization first described the coronavirus outbreak as a pandemic.'
#Covid19 #covıd #publichealth #Vaccines
https://www.ft.com/content/fcddc944-5112-4e32-be22-6ead2bc06cc7
Interview (in Portuguese) with my friend @joanagsa
on equality, implicit bias, and the pernicious myth of meritocracy in academia.
"No entanto, é raro encontrar o mesmo nível de escrutínio ou de julgamento quando gerações de homens brancos promovem outros homens brancos porque são da mesma família ou porque os pais eram amigos de infância. Porque nos lembramos mais de uns casos do que de outros, o nosso cérebro constrói uma narrativa que se perpetua."
'For example, without DeepMind the UK’s share of the citations amongst the top 100 recent AI papers drops from 7.84% to just 1.86%'
https://jameswphillips.substack.com/p/s-and-t-is-the-uk-a-world-leader
Thiago Carvalho
boosted
Fixed-term contracts harm research quality
Rahal et al. (2023). Quality research needs good working conditions. https://doi.org/10.1038/s41562-022-01508-2
Thiago Carvalho
boosted
We (the University of Sheffield) are looking for a Head of Research Software Engineering https://www.jobs.ac.uk/job/CYD056/head-of-research-software-engineering-rse.
It's a amazing role are the intersection of research and software. There's loads of emphasis on improving software practice across UoS as well as providing direct support for research projects.
Thiago Carvalho
boosted
'Here we leveraged an atlas of publicly available RNA-sequencing data of over 500,000 single cells from 15 individuals with AML and tissue from 9 healthy individuals for prediction of target antigens that are expressed on malignant cells but lacking on healthy cells, including T cells.'
'When I first saw the photograph, I didn’t recognize it as an Adams. Josie R. Johnson, a curatorial fellow at the Cantor Center for the Visual Arts at Stanford University, in Stanford, Calif., where I teach, planned to include it in an exhibition. She’d chosen the image for its otherworldly qualities. “It sticks with you,” she said, “for being such an enigma.”
https://www.nytimes.com/2023/03/13/travel/ansel-adams-photograph-sierra-nevada.html
Thiago Carvalho
boosted
Another illustration by Madalena Parreira for the online content I created while at JEM - Dan Davis.
At the time, Davis had just published The Compatibility Gene - the lottery motif alludes to matching MHC types for transplantation. A common theme for this interview and the interview with Matt Cobb (https://flexnersuitcase.wordpress.com/2015/08/17/the-first-five-pages-a-conversation-with-matthew-cobb/) was how scientists find a publisher when they have a book project
https://flexnersuitcase.wordpress.com/2015/09/14/finding-stories-a-conversation-with-dan-davis/
Thiago Carvalho
boosted
Pauls Nurse's full report on the "UK’s Research, Development and Innovation Organisational Landscape" is now published.
A very interesting read with a lot of depth in some places.
My favourite line so far ......
"It is important to recognise that high quality research is difficult to carry out and requires researchers to have the time to think."
Thiago Carvalho
boosted
Drug development sets its sights on ADAR
'RNA editing is rapidly gaining prominence as its transient and reversible changes promise a safer and more flexible option to reverse disease-causing mutations than DNA editing.'
Thiago Carvalho
boosted
"Our data provide a model where the global shutdown of protein synthesis and subsequent rebooting mediated by miR-10b-5p downregulation is a hallmark of the dedifferentiation stage of limb regeneration."
Thiago Carvalho
boosted
A conversation I had with @marcellaflamme from @PLOS about #preprints, #peerreview, AI, and, of course, #ReviewCommons has just been posted on the RC site.
"Q As we ask peer review to do more and more things, should we also be looking at new ways to recognize the work of reviewers?
LaFlamme: Another way to ask that question is: should outputs other than published articles and big grants count toward research assessment and the development of scientific careers?"
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
