Thiago Carvalho @cyrilpedia@qoto.org

"The World Health Organization rebuked Chinese officials on Friday for withholding research that may link Covid’s origin to wild animals, asking why the data had not been made available three years ago and why it is now missing."

https://www.nytimes.com/2023/03/17/health/covid-origins-who.html?smid=nytcore-ios-share&referringSource=articleShare

A good reference to have if you're working with nude mice:

"Here we present the genome assemblies for the NOD/SCID and BALB/c nude strains to overcome this short-coming for the future and improve our understanding of these models in the process."
#Preprint #Immunology

https://www.biorxiv.org/content/10.1101/2023.03.16.532783v1?med=mas

Based on data collected in Uganda between 2003 and 2018.

"This study suggests that male-targeted HIV programs to increase HIV suppression are critical to reduce incidence in women, close gender gaps in infection burden and improve men's health in Africa."

#Preprint #publichealth #hiv

https://www.medrxiv.org/content/10.1101/2023.03.16.23287351v1

"Over and over, trials evaluating PD-1/PD-L1 inhibitors in advanced prostate cancer have missed the mark. The failures have led to questions as to why—and have prompted oncologists to conclude that new treatment strategies are needed."

#Immunology #immunotherapy #checkpointinhibitors #prostatecancer

https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-NB2023-0017/718790/PD-1-Blockade-Falls-Short-Repeatedly-in-Prostate

@schoppik @NicoleCRust I'm sorry the toot provoked a somatic response.

@Rahimilab To me, it makes sense at the repertoire level, at least from the perspective that if you are part of the same social group, you are likely to have some overlap in the universe of antigens, commensals and pathogens you encounter (and transmit within group).

Hanuman inspired ceramics by @hunchbacksociety
#ceramics #handmade #ceramic #stoneware #handmade #ArtMastodon

https://madalenaparreira.com/Hunchbacksociety

"We tracked behavior of rewilded laboratory mice of three inbred strains in outdoor enclosures and examined contributions of behavior, including social associations, to immune phenotypes. We found that the more associated two individuals were, the more similar their immune phenotypes were. Social association was particularly predictive of similar memory T and B cell profiles and was more influential than sibling relationships or worm infection status."

#Preprint #Immunology

https://www.biorxiv.org/content/10.1101/2023.03.15.532825v1?med=mas

This feels like it deserves a drum roll

"But to solidify the case for the hypothetical protoribosome, Yonath and her laboratory would have to build it."

https://www.nature.com/articles/d41586-023-00574-4?utm_source=linkedin&utm_medium=social&utm_content=organic&utm_campaign=CONR_JRNLS_AWA1_GL_SCON_SMEDA_NATUREPORTFOLIO

@schoppik @NicoleCRust
That's interesting, I read her initial toot a bit differently, as one level removed: the job or practice of understanding the scientific job or practice :)

@NicoleCRust (thanks)

I agree - it's a word that probably sends more scientists running for the hills than even philosophy (but closer to what you're getting at, I think).

I wish I had one! To me it also involves an aesthetic component, what it means for a paper or an experiment not just to be important, but "beautiful" (classic examples here are Meselson and Stahl & Luria-Delbruck).

'The World Health Organization said data from China suggesting Covid-19 arose from animals in Wuhan’s wet market should have been shared with the world three years ago, adding that the findings “do not provide a definitive answer” as to the origin of the virus.'

https://www.ft.com/content/939ed85a-2d07-4e11-a3a9-8781f802174f