Thiago Carvalho @cyrilpedia@qoto.org

"In this video essay, the US graphic designer and video producer Jeremy Shuback explores the map’s structure and the breadth of its illustrations, detailing how this imaginative piece of medieval cartography binds history, geography, mythology and religion to form an invaluable sketch of the Middle Ages."

#cartography

https://aeon.co/videos/the-famed-medieval-map-that-stretched-beyond-earth-to-heaven-history-and-myth

From Carl June et al

"A fundamental limitation of T cell therapies in solid tumors is loss of inflammatory effector functions, such as cytokine production and proliferation. Here, we target a regulatory axis of T cell inflammatory responses, Regnase-1 and Roquin-1, to enhance antitumor responses in human T cells engineered with two clinical-stage immune receptors."

#Immunology #immunotherapy #CARTcells

https://www.pnas.org/doi/10.1073/pnas.2218632120

Time to get some duck eggs

The inner homunculus

"Penfield found those visceral signals harder to decipher than the brain's map of the body's surface. Brain regions responsible for different internal sensations seemed to overlap. Sensory regions were hard to distinguish from those that sent motor instructions such as telling the intestines to contract. Penfield once asked participants to swallow an electrode to detect changes in gut contractions while he stimulated their brains. But his map of the inner organs was blurry and ambiguous—and stayed that way for most of the next century."

https://www.science.org/content/article/newly-detailed-nerve-links-between-brain-and-other-organs-shape-thoughts-memories-and?utm_campaign=SciMag&utm_medium=ownedSocial&utm_source=LinkedIn

Lynch lays out the complex reasoning behind his decisions to make the occasional commercial

https://www.youtube.com/watch?v=GiP85kdyRLo

In other news, blue skies and cork.

"Nothing less than complete enthusiasm will satisfy: you must at all times be thrilled to announce, excited to be part of, delighted to share. In this context, marking – which at most universities involves uploading long lists of numbers to creaking online portals that crash with abandon – is one of the few remaining repositories for an acceptable ennui, an apolitical ire. It unites the divided: everyone hates marking."

https://www.lrb.co.uk/the-paper/v45/n06/lorna-finlayson/diary

"Loam’s fungal treatment helps the soil store more than double the amount of carbon compared to that of conventional regenerative agriculture, while healthier soils retain more water and other nutrients, thereby increasing production."

https://www.ft.com/content/71422ca3-6cc8-46c3-9f59-768a501b85f3

"Scholars had previously identified three potential centers of domestication, in the Near East, northeast Africa (including Egypt) and the Arabian Peninsula. But Dr. Orlando’s team concluded that donkeys — humanity’s first land-based transport — were domesticated only once, around 5,000 B.C., when herders in the Horn of Africa and present-day Kenya began to tame wild asses."

https://www.nytimes.com/2023/03/14/science/donkeys-genetics-archaeology.html

@albertcardona cc @ChristenMirth

Tools

"To complement existing tools of small-molecule-based inhibitors, we present a highly potent, novel catalytically-driven glucocorticoid receptors degrader, KH-103, based on proteolysis-targeting chimera technology."

#Neuroscience #behavior #endocrinology

https://www.biorxiv.org/content/10.1101/2023.03.17.533120v1

"Los universitarios españoles presentan una alta prevalencia de problemas emocionales y académicos tras la pandemia del coronavirus. Más de dos tercios del alumnado de la universidad española presenta sintomatología ansiosa ―un 47,6% alcanza puntuaciones indicativas de caso clínico de ansiedad y otro 24,9%, de caso probable―, mientras que más del 40% de los universitarios españoles reconoce sintomatología depresiva."

https://elpais.com/educacion/2023-03-18/dos-tercios-de-los-universitarios-espanoles-tienen-ansiedad-tras-la-pandemia.html

"I started taking notes during presentations, and logging slide formats or delivery styles that made it easier for me to stay focused. Once I identified a potentially useful technique, I applied it during my own talks and asked for feedback from colleagues. Their positive comments reinforced to me that the techniques I found useful as an audience member helped and resonated with non-ADHD audience members as well. Here are some of those strategies."

https://www.science.org/content/article/learned-craft-compelling-scientific-presentations-spurred-adhd