Thiago Carvalho @cyrilpedia@qoto.org

'Even without exposure to antigens, some CARs increase proliferation and nutrient uptake in T cells. Using stable isotope tracers and mass spectrometry, we observed basal metabolic fluxes through glycolysis doubling and amino acid uptake overtaking anaplerosis in CAR-T cells harbouring a rituximab scFv, unlike other similar anti-CD20 scFvs.'
#Immunology #Immunotherapy #CARTcells
https://www.nature.com/articles/s42255-024-01034-7

'Depuis le coup de tonnerre de la dissolution, le monde de la recherche a multiplié les prises de position publiques pour dénoncer les périls qui accompagneraient l’arrivée au pouvoir du Rassemblement national (RN). Avant même le premier tour des législatives, cinq Prix Nobel français, associés à de nombreux chercheurs, soulignaient, le 25 juin, dans une tribune au Monde, que cela constituerait « une menace grave et immédiate pour la recherche et l’enseignement supérieur en France », du fait de « positions xénophobes et nationalistes » qui « isoleraient la France de la communauté scientifique internationale ». Le Collège de France, l’Académie des sciences et d’autres institutions scientifiques ont, depuis, fait état de leurs inquiétudes.'
https://www.lemonde.fr/politique/article/2024/07/03/legislatives-2024-la-recherche-tetanisee-par-la-perspective-d-une-victoire-du-rassemblement-national_6246529_823448.html?lmd_medium=al&lmd_campaign=envoye-par-appli&lmd_creation=ios&lmd_source=default

'Stimulator of IFN genes (STING) is a critical component of the innate immune system, playing an essential role in defending against DNA virus infections. However, the mechanisms governing basal STING regulation remain poorly understood. In this study, we demonstrate that the basal level of STING is critically maintained by hypoxia-inducible factor 1 (HIF-1)α through transcription.'
#Immunology #InnateImmunity
https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2400123/266986/HIF-1-Transcriptionally-Regulates-Basal-Expression?redirectedFrom=fulltext

'Protein synthesis and decay rates must be tightly coordinated to ensure proteome homeostasis. How this coordination is established is unknown. Here we use quantitative live cell imaging combined with computational inference to determine how changes in global protein synthesis rates alter protein decay rates'
#Preprint
https://www.biorxiv.org/content/10.1101/2024.07.04.602056v1

'Para que isso aconteça, o exemplo da Frente Popular original é ainda o melhor guia. É o foco no bem-estar das pessoas, na qualidade de vida e na capacidade de os empregados e trabalhadores terem rendimento suficiente para terem uma vida digna e confortável que terão de estar os objetivos que permitirão afastar a França do abismo de um colapso do Estado de direito, da democracia e dos direitos fundamentais.'
@ruitavares
https://expresso.pt/opiniao/2024-07-04-a-franca-frente-a-frente-71652e29

'Stanford, the SIO’s institutional home, denies that it is dismantling the unit and loudly proclaims its commitment to independent research. On the other hand, according to DiResta, the university has run up “huge legal bills” defending SIO researchers from harassment by Republican politicians and conservative conspiracy theorists, and may have decided that enough is enough.'
https://www.theguardian.com/commentisfree/article/2024/jun/29/closing-the-stanford-internet-observatory-will-edge-the-us-towards-the-end-of-democracy

'It’s been clear for some time what went wrong, but almost none of those issues have been fixed. That means that the next desperately needed vaccine stands every chance of running into those same problems.'
https://www.nytimes.com/2024/07/05/health/malaria-vaccine-delay.html

'Como ex-bolseiros de investigação e técnicos superiores doutorados na FCT, consideramos que o papel da fundação necessita ser repensado, superando o paradigma a que se tem remetido, enquanto mera agência de financiamento, abrindo-se à comunidade científica, tornando-se uma verdadeira casa dos investigadores, e convocando para si um papel de charneira, como plataforma de permanente diálogo entre a administração e a investigação, ao serviço de todos.'
https://www.publico.pt/2024/07/06/ciencia/opiniao/qualificar-fct-2096511

Phage v Phage
'Birkholz et al. have discovered that a mobile intron containing a homing endonuclease found within a viral RNA polymerase gene in one bacteriophage blocks productive infection by a related and competing coinfecting bacteriophage.'
https://www.science.org/doi/10.1126/science.adl1356