Thiago Carvalho @cyrilpedia@qoto.org

People is doing a better job than CNN and The NY Times. https://people.com/what-is-project-2025-inside-far-right-plan-trump-presidency-8622964 #project2025 #heritagefoundation #MAGA #trump

Advanced Professional, Research Technician, Molecular Biology & Symbiosis

The Pennsylvania State University

Do you have a professional interest in optimizing and advancing molecular biology, entomology, microbial symbiosis, or reproductive biology?

See the full job description on jobRxiv: https://jobrxiv.org/job/the-pennsylvania-state-univers...
https://jobrxiv.org/job/the-pennsylvania-state-university-27778-advanced-professional-research-technician-molecular-biology-symbiosis/?feed_id=77951

When even the finance industry turns against #AI you know it's time is up.
https://www.cityam.com/goldman-sachs-tony-blair-is-wrong-on-ai-its-not-going-to-save-the-uk-economy/

'The time dimension is fundamental because currently, without new tools, characterisation of tuberculosis states such as subclinical non-infectious (or incipient tuberculosis) is only possible when reviewing the history of cases before diagnosing microbiologically confirmed tuberculosis. By examining the trajectory of people who are later identified to have microbiologically confirmed tuberculosis, we will be able to identify when and if they had subclinical non-infectious tuberculosis at an earlier time.'
(ht @gpollara)

https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(24)00140-X/fulltext

'The voluntary code of practice, published today, prohibits researchers from implanting embryo models made from human stem cells into the uterus of a living person or other animal. But it does not set fixed time limits on how long models can be grown in the laboratory, as some other countries have proposed. Instead, the code requires that projects propose their own limits on the basis of the minimum time needed to achieve their scientific objectives, and that an oversight committee be established to review and approve projects.'
https://www.nature.com/articles/d41586-024-02171-5

'On 21 June, Barcelona mayor Jaume Collboni announced plans to ban short term rentals in the city starting in November 2028. The decision is designed to solve what Collboni described as "Barcelona's biggest problem" – the housing crisis that has seen residents and workers priced out of the market – by returning the 10,000 apartments currently listed as short-term rentals on Airbnb and other platforms into the housing market.'
https://www.bbc.com/travel/article/20240701-what-does-a-world-without-airbnb-look-like

'As a Postdoctoral Fellow in the Therapeutic Area of Immunology Discovery, pRED, you will focus on an exploratory research project to develop the most-advanced in vitro model of human intestinal inflammation described to date. This position also entails close interaction with the Organoid Engineering group at the Institute of Human Biology.'

https://institutehumanbiology.com/about-the-ihb/careers/roche-postdoctoral-fellow-rpf-in-in-vitro-models-of-intestinal-inflammation/

'The first patient to receive a kidney from a genetically engineered pig was Richard Slayman, 62, who had the procedure in March at Mass General Brigham in Boston. Though he was well enough to be discharged two weeks after the surgery, he, like Ms. Pisano, suffered from complex medical problems and died within two months.'

https://www.nytimes.com/2024/07/09/health/kidney-transplant-pisano.html

'Agassiz and others used polygenism to boost scientific support for slavery, to the extent that, as the anthropologist Charles Loring Brace points out in ‘Race’ is a Four-Letter Word (2004), their advocacy became a contributing factor to the American Civil War.'

https://aeon.co/essays/modern-racism-rests-on-scientific-theories-from-the-19th-century

'Keytruda has beaten Roche’s TIGIT drug candidate at the first interim analysis of a phase 2/3 lung cancer trial, prompting the Swiss drugmaker to stop the study and consider changes to the broader program.
(...)
Roche found the survival data favored the Keytruda regimen at the first interim analysis. The assessment of progression-free survival (PFS) generated a hazard ratio of 1.27.'
#Immunotherapy #Immunology
https://www.fiercebiotech.com/biotech/roche-stops-pivotal-tigit-trial-after-keytruda-lands-knockout-blow-first-attempt

'Medical experts in Japan are to add a “most severe” category to the current heatstroke index, amid warnings that the extreme heat is straining medical services and causing damage to public health comparable to that in a “natural disaster”.'

https://www.theguardian.com/world/article/2024/jul/10/japan-adds-most-severe-category-to-its-heatstroke-index-amid-deadly-summer

'We observed that multiple aspects of science identity were positively impacted by participation in the mentorship program, including mentees’ sense of belonging to the community of scientists (80%), feeling that their identity and background are welcomed in their academic program (88%), feeling like they belong in science (90%), their perception of the daily work of scientists (83%), sense of value as a scientist because of their identity and background (71%), and certainty of their place in science (68%).'

https://www.biorxiv.org/content/10.1101/2024.04.02.587784v1

'A play, Kyoto — which had its world premiere last month at the Royal Shakespeare Company’s Swan Theatre in Stratford-upon-Avon, UK — attempts to cast a fresh light on climate narratives by focusing on the negotiations of the Kyoto Protocol. This international treaty, signed on 11 December 1997 in Kyoto, Japan, was the first to commit countries to reduce their greenhouse-gas emissions to mitigate climate change.'

https://www.nature.com/articles/d41586-024-02251-6

'Here, we developed a multi-tumor mouse model system to track hundreds of expanding and contracting CD8+ T cell clones over multiple timepoints in tumors of the same individual. Through coupling of clonal expansion dynamics and single-cell RNA/TCR-seq data, we identified a transcriptomic signature in PD-1+Ly108+ precursor exhausted cells that strongly predicts rates of intratumoral clone expansion in mice and humans.'
#Preprint #Immunology

https://www.biorxiv.org/content/10.1101/2024.07.05.601623v1