Thiago Carvalho @cyrilpedia@qoto.org

'In the end, Bell Labs was ultimately undermined by the very technologies that it had created. The world that Bell Labs thrived in no longer exists: to push technological progress forward, we'll need to understand both why Bell Labs worked and why it no longer could.'
(via The Browser)

https://www.construction-physics.com/p/what-would-it-take-to-recreate-bell?ref=thebrowser.com

'Combining our amphioxus dataset and publicly available data from the mouse, zebrafish, tunicate, sea urchin and sea anemone, we uncovered a tripartite origin of the chordate CNS from anterior, posterior and NMP populations (Extended Data Fig. 7c).'

https://www.nature.com/articles/s41559-024-02469-7#Sec10

'Our results imply that nervous systems converged onto synaptic density invariance to stabilise neuronal responses, suggesting a simplifying principle for neural circuit function, assembly and evolution.'

#Neuroscience #Preprint

https://www.biorxiv.org/content/10.1101/2024.07.18.604056v1?med=mas

If a drug to achieve longevity is ever discovered, it is highly unlikely to work on women, because labs across the world are filled with white mice who are exclusively male.

Yet the sex differences between rodents are highly significant.

Reflecting a profound sex bias, 'Methuselah's Zoo' author Dr. Peter Austad says more progress has not been made in extending women’s healthy longevity because researchers are not interested in studying it.

https://www.theguardian.com/science/article/2024/jul/22/sex-bias-labs-women-losers-research-ageing

#woman #health #aging

#sciences #biology Are animals conscious? We’re finally realising that many species are
Science is at last confirming what many people have long suspected - that mammals, birds and perhaps some invertebrates have elements of consciousness https://www.quantamagazine.org/insects-and-other-animals-have-consciousness-experts-declare-20240419/

Head-to-head comparison of aptamer- and antibody-based proteomic platforms in human cerebrospinal fluid samples from a real-world memory clinic cohort https://www.medrxiv.org/content/10.1101/2024.07.18.24310563v1.full.pdf+html

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#proteomics #prot-preprint

'We discovered that the Neisseria gonorrhoeae transcriptional response to PMNs has features in common with the transcriptional response to nutrient metals and oxidative stress, which enhance Neisseria gonorrhoeae resistance to hydrogen peroxide & polymorphonuclear leukocytes.'
#Immunology #HostPathogen

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012369#sec010

#IDMastodon #immunology #SARSCoV2 evolution prompts the quest for other protective antibody mechanisms beyond neutralization .Non-neutralizing mAbs might target epitopes with less evolutionary selection pressure to mutate in #SARSCoV2 variants VS neutralizing mAbs

https://www.cell.com/trends/immunology/fulltext/S1471-4906(24)00152-2?rss=yes&utm_source=dlvr.it&utm_medium=twitter

"I reflect on my own PhD candidature to illustrate how article processing charges disempower doctoral candidates." - Article processing charges suppress the scholarship of doctoral students https://ese.arphahub.com/article/124173/

AQuaRef: Machine learning accelerated quantum refinement of protein structures https://www.biorxiv.org/content/10.1101/2024.07.21.604493v1.full.pdf+html

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#proteomics #prot-preprint

Timothy Snyder on "both sides" - a cult of duality which we should have learned from by now. Have seen people get sucked into fascist thinking because of this.

https://snyder.substack.com/p/both-sides

✳️Producing #green #hydrogen for industrial & transport applications🔋

♻️By utilising 100% renewable #electricity, #Luxembourg Hydrogen Valley (LuxHyVal) will produce green hydrogen locally & implement initiatives across the entire value chain by 2026.
➡️https://www.researchluxembourg.org/en/luxhyval-luxembourg-hydrogen-valley/

LuxHyVal is a collaborative project of 17 partners from 7 countries. If successful, the project aims to expand its initiatives to the #CzechRepublic & #Ukraine️

#ResearchLuxembourg #research #renewableenergy

Reading
A Child in Palestine
The cartoons of Naji-al-Ali
2009 Verso Publishing

#Palestine #Handala #Hanthala
#cartoons #art #NajiAlAli

PhD studentship in quote post below to characterise aphid immune evolution. Lots to uncover in an insect group with major ecological & economic impact. Aphid systemic immunity is a black box. The interested PhD candidate will both provide one of the first detailed descriptions of aphid immunity, but also uncover principles of immune evolution.

Deadline July 29th at #UoExeter
Email or DM for details🐘 📩
m.hanson@exeter.ac.uk

#Genomics #Aphid #Genetics #ImmunoSky #Drosophila

'Researchers performed a systematic assessment of the circular DNA structures by analysing more than 2,500 plasmids produced in labs and sent to a company that provides services such as packaging the structures inside viruses so they can be used as gene therapies. The team found that nearly half of the plasmids had design flaws, including errors in sequences crucial to expressing a therapeutic gene.'
https://www.nature.com/articles/d41586-024-02280-1