Thiago Carvalho @cyrilpedia@qoto.org

'Similar to SARS-CoV-2, BANAL-CoVs use human ACE2 to enter cells. However, whether BANAL-CoVs can overcome human innate and adaptive immunity and undergo efficient transmission represents a crucial knowledge gap. Characterizing and defining barriers to efficient human infection is critical to better predict the zoonotic potential of bat CoVs and to enhance pandemic preparedness'
#Covid #Coronavirus
https://www.nature.com/articles/s41564-024-01765-z

VONNEGUT
There has to be. Because you can lose a reader in a blink of an eye. If a person is an engineer or chemist or an anthropologist or whatever, you spoil the whole book for that person if there’s obviously ignorance here. What’s wrong with so much science fiction is that the science is so lousy that it isn’t worth paying attention to. My brother was a distinguished scientist and I hung out more with scientists than I did with writers, so the one thing I’ve always tried to do was to get it right, make it plausible. Scientifically. How long it takes to get somewhere through space and what you ‘re likely to find there, and you have to figure whether it’s going to be plausible or not. So, yeah, I did a book called Galapagos which was about evolution and it’s used in courses now.

https://www.robertcaro.org/post/an-interview-with-robert-caro-and-kurt-vonnegut

'For many people, a routine blood test is easier to get than a colonoscopy or a fecal sample test. But the blood test, made by Guardant Health of Palo Alto, Calif., comes with a limitation. Unlike other screening tests for colon and rectal cancers, it has a poor record of finding precancerous growths. Removal of those growths can prevent cancer.'

https://www.nytimes.com/2024/07/29/health/colon-cancer-blood-test-shield.html

'Hungary this month published details of a new fast-track visa system for citizens of eight countries, including Russia and Belarus, to enter Hungary without security checks or other restrictions. Budapest said many would be building a nuclear power plant with Russian technology. '
https://www.ft.com/content/b2a4ebd8-df41-43fe-8d63-602c1d50e899

@lymphomation It will be a long and winding road.

'We demonstrate the first generalizable strategy using a small molecule to selectively kill TP53 mutant cells. This molecule binds the Y220C mutant of p53 and concentrates a PLK1 inhibitor in cells harboring TP53 Y220C mutations.'
#Preprint
https://www.biorxiv.org/content/10.1101/2024.07.27.605429v1

Metformin + anti-PD1

"We found that the combination therapy promotes the pericyte coverage of tumor vascular endothelial cells (ECs) to improve blood perfusion and that it suppresses the hyperpermeability through the increase of VE-cadherin. Peripheral node addressin(PNAd) and vascular cell adhesion molecule (VCAM)-1"
#Immunology #Immunotherapy
https://www.pnas.org/doi/10.1073/pnas.2404778121

'Reliant largely on dwindling supplies from Soviet and American cold war-era stockpiles of precursor radioactive materials, companies have struggled to obtain enough actinium to treat the thousands of patients being enrolled in clinical trials.'

https://www.ft.com/content/6ce668bc-4180-4e84-9feb-f25ac0e83f6f

'Alguns dos problemas decorrentes de um crescimento excessivo do turismo são evidentes e bem conhecidos de toda a população. A OCDE alerta para aspectos como as pressões sobre os preços do alojamento (que dificultam o acesso à habitação dos residentes e também dos trabalhadores sazonais), sobre as infra-estruturas e os serviços colectivos (traduzindo-se, por exemplo, na sobrelotação dos transportes públicos ou na acumulação de lixo nas zonas mais frequentadas) e sobre o ambiente (aumentando a poluição e pondo em causa a sustentabilidade dos ecossistemas e a biodiversidade). Os crescentes protestos populares em zonas de grande intensidade turística – como Barcelona ou Málaga, para dar dois exemplos recentes – são um sinal de que o excesso de turismo existe de facto e que está a tornar-se um problema político sério em diferentes partes do mundo.'

https://www.publico.pt/2024/07/29/opiniao/opiniao/vamos-assumir-turismo-tornou-problema-2099079