Thiago Carvalho @cyrilpedia@qoto.org

'We used Bacillus Calmette-Guerin (BCG), a live-attenuated vaccine, to train the innate immune system and detected epigenetic reprogramming of brain-resident myeloid cells and functional restoration of myelin debris clearance and lesion recovery.'
#Immunology #Neuroimmunology
https://www.cell.com/immunity/fulltext/S1074-7613(24)00348-0

'The government should look at ways of making it easier for medics to adopt new life-saving innovations. A framework for sepsis and infection management, akin to those for heart attack and stroke, would also help. As Daniels notes, sepsis affects more people than heart attacks and claims more lives than strokes.'
https://www.ft.com/content/9537418a-8796-430f-8de9-fcc691240c5b

Genomes fm chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan, and siamang:
"We resolve challenging regions, such as the major histocompatibility complex and immunoglobulin loci, providing more in-depth evolutionary insights."
#Genomics #Immunology #Preprint
https://www.biorxiv.org/content/10.1101/2024.07.31.605654v1

'What's surprising is that these things don't go on to show the same toxicity to eukaryotic cells, and I have to say, I wouldn't have expected that, especially since the initial screens used eukaryotic DNA). But the degree of DNA-induced aggregation correlates quite well with the antibacterial activity (and for that matter, the degree of self-aggregation is a pretty good surrogate for the DNA-induced aggregation).'
https://www.science.org/content/blog-post/new-way-kill-bacteria

'Cheap and efficient assessment methods that can be used in distance education, such as unsupervised online tests, spread with the Covid-19 pandemic. Yet, with the pandemic now behind us, many such assessments that are vulnerable to cheating are still used more than they used to be by time-poor academics in cash-strapped universities.'
https://www.theguardian.com/australia-news/commentisfree/article/2024/aug/01/i-know-why-students-its-time-for-australian-universities-to-do-something-about-it?CMP=aus_bsky

'Analyses of R&D spending and equity investment in biotech predict that the industry is capable of weathering a drop in revenue due to lower drug prices, with no corresponding loss in new approved drugs.'

https://www.fiercebiotech.com/research/analyses-predict-reduction-drug-prices-due-inflation-reduction-act-wont-hurt-biotech

'Langerhans cell Histiocytosis (LCH) and Erdheim-Chester disease (ECD) are clonal myeloid disorders, associated with MAP-Kinase activating mutations and an increased risk of neurodegeneration. Surprisingly, we found pervasive PU.1+ microglia mutant clones across the brain of LCH and ECD patients with and without neurological symptoms, associated with microgliosis, reactive astrocytosis, and neuronal loss.'
#Preprint
https://www.biorxiv.org/content/10.1101/2024.07.30.605867v1

'High cholesterol in the over-40s and hearing impairments were most commonly associated with people developing dementia globally, according to new research by The Lancet Commission on dementia prevention, intervention and care.'

https://www.ft.com/content/20422086-56cb-4b53-ad36-dbc4797dbf59