Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'The clinical trial death, described in an unpublished case report Science has obtained, is the second thought to be associated with the antibody called lecanemab. The newly disclosed fatality intensifies questions about its safety and how widely lecanemab should be prescribed if ultimately approved by regulators.'
Thiago Carvalho
boosted
Hi, we're now on Fediscience! #Introduction
We're an #OpenAccess not-for-profit journal that publishes and reviews #research in the life and biomedical sciences.
We want to improve the way research is practised and shared in part by working with early-career researchers #ECR and supporting #OpenSource technology.
We also just announced our new publishing model that we hope will tackle an overreliance on journal titles and publishing decisions as quality measures for science and scientists.
Thiago Carvalho
boosted
Thiago Carvalho
boosted
Our December issue is live! Highlights: A Perspective on genetic variation in human PSCs, CD47 as a target for muscle rejuvenation, post-mitotic #senescence as a feature of AD, a tendon progenitor that enhances #regeneration, and a reference line for #hPSC studies https://tinyurl.com/2ccaj3vp #stemcells
Thiago Carvalho
boosted
I think it's about time for me to make a #introductionpost
My name is Simon Bohn, I'm a PhD candidate in @NicoleCRust 's lab where I study how we remember what we've seen. I'm particularly interested in how we generalize across visual memories.
Outside of science, I love taking pictures with antique cameras, growing #orchids and trying to bake the perfect loaf of bread
'From the early days of the HIV pandemic when advocates stormed the US National Institutes of Health (NIH) to make their priorities known, stakeholder engagement to drive the research agenda has been a cornerstone of the HIV research response. The HIV research enterprise is much improved by the broad involvement of community members on research teams and advisory boards—not only in the United States, but globally, through networks that were established to foster research and care in regions and populations most affected by HIV.'
https://onlinelibrary.wiley.com/doi/10.1002/jia2.26039#.Y4dj7NVzIxw.twitter
New preprint from Valeria Fumagalli, @iannaconelab et al
"Nirmatrelvir treatment blunts the development of antiviral adaptive immune responses in SARS-CoV-2 infected mice"
"In 2001, he declines, in scathing tones of barely contained fury, an invitation to speak to the employees of the pharmaceutical company Novartis, whose industry he attacked in his novel “The Constant Gardener.” “I think I struck a nerve, and made you angry,” le Carré writes. “Which, believe it or not, is one of the most useful functions that a free writer can perform in an era of insufferable corporate arrogance.”
https://www.nytimes.com/2022/11/30/books/lecarre-book-letters.html
'This Review summarizes our current understanding of the molecular basis for the involvement of phosphoinositide kinases in disease and assesses the preclinical and clinical development of phosphoinositide kinase inhibitors.'
'Here, we discuss three preprints that take advantage of the experimental strengths of #hPSC-derived tissues to investigate new mechanisms in development and disease. In one preprint (Wong et al., 2022 preprint), the authors have developed an hPSC model to investigate the mechanisms by which a rare and transient population of cells, the ventral foregut endoderm, becomes committed to specific endoderm lineages. We also discuss two preprints (Victor et al., 2022 preprint; Zhao et al., 2022 preprint) describing how hPSCs are being used to identify which cell types in the brain are driving the pathology of a genetically caused form of #Alzheimer's disease.'
Thiago Carvalho
boosted
“People always say that I didn’t give up my seat because I was tired but that isn’t true. I was not tired physically… No, the only tired I was, was tired of giving in.”
#OnThisDay, 1 Dec 1955, Rosa Parks does not give up her seat on the bus for a white passenger, and is arrested. Although not the first black woman to be arrested Parks' refusal is a key moment in the American civil rights movement.
#WomenInHistory #RosaParks @histodons #Histodons
Thiago Carvalho
boosted
In the USA, the NIH budget is about five times the NSF budget. We "sneak" basic science in, under cover of justifying the work as bettering human health. Maybe this needs to be rethought.
https://www.nature.com/articles/d41586-022-04172-8
Thiago Carvalho
boosted
#Introduction. We are a #nonprofit #publisher located in Heidelberg, Germany, and publish five #lifesciences journals: @embojournal, @EmboMolMed, @MolSystBiol, EMBO Reports and (in cooperation with RUP & CSHLP) Life Science Alliance.
Posts about publishing policy, including #transparency, #openaccess and peer review.
Thiago Carvalho
boosted
miRNAs in octopus neural tissue comparable to humans.
Likely because humans and octopuses descended from the same worm-like animal that lived 518 mya
MicroRNAs are deeply linked to the emergence of the complex octopus brain
https://www.science.org/doi/10.1126/sciadv.add9938
Thiago Carvalho
boosted
@richardsever not sure about the word "decoupled". Preprint peer review can be journal-independent but it does not obligatorily mean it becomes "decoupled" from downstream journal publishing. We can discuss about the role of journals in the future, but journal-independent review can remain journal-compatible as in the @ReviewCommons system It might be actually a good driver for change (it already is).
Thiago Carvalho
boosted
#RecognizingPreprintReview meeting gathering steam. With advocacy from people like Erin O'Shea (HHMI President) and Fiona Watt (EMBO President), it does seem there is a serious push to the kind of decoupled preprint-centered ecosystem we have proposed.
Critical point from James Fraser (UCSF) that 20% of his research output is peer reviews, these were seen by almost no-one, but now can be if posted alongside the preprint.
Thiago Carvalho
boosted
"Please tell me that you remembered to approve track changes and removed all the comments before you submitted the paper"
'However, no direct evidence exists as to if and how laryngeal and ventricular structures can vibrate to produce sound in bats due to challenges of imaging the vocal folds in vivo at the extremely high speeds required.
Here, we test the hypothesis that specialization of different laryngeal structures supports the extreme frequency range of FM bats. We test this hypothesis in Daubenton’s bats (Myotis daubentonii) that have an extreme 77 octave fo range from 1 to 95 kHz '
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001881
'There’s a sweet response to 10-year-old Nicholas Greaves, who in 1988 asks le Carré for tips on becoming a spy. “To be a spy, you need first to know what you think about the world, whom you would like to help, whom to frustrate,” le Carré responds. “Also, you have to decide how much you are prepared to do by dishonest means.”
https://www.nytimes.com/2022/11/30/books/lecarre-book-letters.html
'Yet we keep hearing that public health has failed us during this pandemic. From right and left, from print journalists to talking heads, the mess we’re in gets laid at the feet of those of us working in the field—as if we have any influence on the circus going on in Washington, D.C., or in statehouses across the country, where quacks like Florida’s surgeon general, Joe Ladapo, spout nonsense about vaccines.'
@gregggonsalves #TheNation #PublicHealth #COVID
https://www.thenation.com/article/society/public-health-covid-pandemic/
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
