Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"From the title of Heather Radke’s new book “Butts: A Backstory,” and its cover image of a ripe, callipygian peach, one might expect a book of provocative photos, or perhaps a chronicle of a personal fetish. But “Butts” is in fact a carefully researched and reported work of cultural history."
https://www.nytimes.com/2022/11/28/style/butts-a-backstory-radke.html
Medicine should not be a business: the c-section rate at Portugal's private hospitals is more than TWICE the rate at public hospitals.
(link goes to news article in Portuguese)
Thiago Carvalho
boosted
RT @Johanna_A_Joyce@twitter.com
Spatial Multi-Omics: Use in Biology & Medicine
Join us on Jan 18 in Lausanne for a great symposium with fantastic speaker line up!
Abstract deadline for short talks & posters is Dec 9
@RongFan8@twitter.com @BodenmillerLab@twitter.com @roserventotormo@twitter.com @GioeleLaManno@twitter.com
@FondationIsrec@twitter.com @FBM_UNIL@twitter.com @epflSV@twitter.com https://twitter.com/Johanna_A_Joyce/status/1587802163375489032
🐦🔗: https://twitter.com/Johanna_A_Joyce/status/1598597408539246592
Thiago Carvalho
boosted
#Drosophila #Advent Day1: A close relative of D. melanogaster, D. simulans is both similar & different … https://link.springer.com/book/10.1007/978-94-007-0965-2. A member of the melanogaster subgroup, Dsim probably evolved in #Madagascar but went unnoticed until it was a global commensal—being mistaken for its more famous sibling in the lab https://academic.oup.com/genetics/article/177/4/1969/6064435. Dsim is rarer in the UK (I’ve only caught them 3 times), and unlike Dmel, they are not keen on coming indoors https://www.jstage.jst.go.jp/article/pjab1945/52/4/52_4_191/_article #NaturalHistory #Entomology
Thiago Carvalho
boosted
New UKRI report on Inequality in UK Life Sciences. https://www.ukri.org/wp-content/uploads/2022/11/BBSRC-301122-BBSRCInequalityInECRReport.pdf
"We find race/ethnic inequalities in the transition from first-degree to postgraduate research degrees in life sciences subjects; these are not accounted for by academic attainment."
Thiago Carvalho
boosted
Our latest issue (11/2022) ➡️ bit.ly/3ARhSWb
#singlecell, #synbio, #gutmicrobiome, #metabolomics, RV on #microscopy-based pooled genetic screens...
On the cover: the metabolic landscape of 180 cancer cell lines - from BA Hall, UCL & N Zamboni, ETH (Image by Scistories LLC)
#SystemsBiology
"For at least two centuries, scientists have been enthralled by the zombie behaviors induced by mind-controlling parasites. Despite this interest, the mechanistic bases of these uncanny processes have remained mostly a mystery. Here, we leverage the recently established Entomophthora muscae-Drosophila melanogaster zombie fly system to reveal the molecular and cellular underpinnings of summit disease, a manipulated behavior evoked by many fungal parasites"
#Drosophila #Neuroscience #Parasitology #preprint
https://www.biorxiv.org/content/10.1101/2022.12.01.518723v1?med=mas
Thiago Carvalho
boosted
Yu Xuan Lu (not yet in the fediverse) and I are happy to share the publication of our work on sex differences in intestinal responses to the anti-#ageing drug #rapamycin, in the making for some time (more years than I care to calculate :)
"As a metaresearcher studying peer review, I am struck by how vague the concept is. It conflates the evaluation of rigour with the curation of what deserves space in a journal. Whereas the first is key to keeping the scientific record straight, the second was shaped in an era when printed space was limited."
#PeerReview
https://www.nature.com/articles/d41586-022-03791-5
Thiago Carvalho
boosted
Nice special issue on sex chromosome evolution https://onlinelibrary.wiley.com/toc/14209101/2022/35/12
including "X chromosomes show relaxed selection and complete somatic dosage compensation across Timema stick insect species" by Parker et al @KamilSJaron (other authors not on 
)
#EvolutionaryBiology #SexChromosomes @dee_unil
Thiago Carvalho
boosted
RT @JulesBulssico
I'm very excited to share the preprint of the work I did at the phage team of @MireilleLCB at @lcb_officiel! Here we studied how phage predation is reshaped in the presence of filamentation-inducing antibiotics, and its impact on bacterial mutagenesis! 🧬
https://www.biorxiv.org/content/10.1101/2022.11.28.518157v1
Thiago Carvalho
boosted
It has happened! The FDA in the US has approved Rebyota as the first fecal microbiota transplantation-based medicine on the market for recurrent C. difficile infection.
This product had good efficacy and less convincing safety, but on the whole it's likely to provide more options for individuals with recurrent C. diff.
https://www.fda.gov/news-events/press-announcements/fda-approves-first-fecal-microbiota-product
Classic reviewer comments:
'The work certainly established his empirical case in the Origin of Species. His enthusiasm for pigeons as a case study was so apparent in his manuscript for Origin of Species that the prepublication reviewer—who did not at all care for Darwin’s secularizing account of the origin of animals and plants—recommended that Darwin write instead a short book on pigeons. “Everybody is interested in pigeons,” the reviewer said'
Thiago Carvalho
boosted
How important is the preservation of the integrity of the scientific record for scholarly journals? Exhibit #937246534, Science Magazine:
---
RT @ScienceMagazine
Tessier-Lavigne immediately contacted Science and agreed to follow up. Working with Science editorial, Tessier-Lavigne prepared Errata for both papers. However, due to an error on our part, Science never posted these Errata. (2/3)
https://twitter.com/ScienceMagazine/status/1597999050997043201
Thiago Carvalho
boosted
So, dear #chemistry #chemiverse, I have created a group called @chemistry. If you tag the account in your toot it should auto boost the toot, to see those boosted toots in your timeline, follow the group. Hope that makes sense.
Thiago Carvalho
boosted
What drives interactions between cis-regulatory elements at different scales?
Happy to share our latest preprint from the Bickmore lab where we describe ultra-long-range interactions between active promoters and enhancers independent of cohesin and polycomb!
We propose interactions between cis-regulatory elements are driven by three independent mechanisms: loop extrusion, polycomb contacts, and association between active regulatory elements across large distances.
'Strange, spooky, funny: Gillian Wearing’s Imagined Mask of Joan Crawford as Bette Davis in Whatever Happened to Baby Jane, created with AI - DALL-E 2. Photograph: © Gillian Wearing/Courtesy Maureen Paley, London'
https://www.theguardian.com/artanddesign/2022/dec/01/six-leading-british-artists-making-art-with-ai
Thiago Carvalho
boosted
Hi all! Very chuffed my team's Host-Pathogen Phylogeny Project (HP3) is a finalist for the DataWorks! Prize, an award for innovative and impactful data sharing and #OpenScience.
You can 🗳️ vote for the people's choice award, and we'd very much appreciate 🙏 your votes and boosts. 
https://www.herox.com/dataworks/round/2457/entry/41361
There are many great projects among the finalists, but I think HP3 is special - a brief 🧵 on why:
"What does this mean for art? Is it the end of our run as the only art-making species? Or can humans and machines work together to create something wondrous? To find out, I challenged six outstanding human artists, including three Turner prize-winners, to experiment with AI."
https://www.theguardian.com/artanddesign/2022/dec/01/six-leading-british-artists-making-art-with-ai
Thiago Carvalho
boosted
Glad to see our COVID-19 study published in JCI Insight. We followed antigen-specific B cell clones longitudinally in patients during hospitalization and thereafter for up to 1 year (after vaccine).
https://insight.jci.org/articles/view/165299
Work led by postdoc
Lydia, PhD stud Hannes and former postdoc Katerina.
Fantastic collaboration involving many, including Mats Bemark, Ben Murrell, Anna Lundgren and other.
Thanks to @ERC_Research, ScilifeLab, KAW and VR for funding
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
