Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Small (5 patients)) #Alzheimer #GeneTherapy study with APOE4 homozygotes
"That leads to the idea that if gene therapy floods the brain with APOE2, converting the brain milieu of a person with two APOE4 variants to one that resembles that of a person with one APOE4 and one APOE2, it could possibly slice Alzheimer’s risk in half."
https://www.nytimes.com/2022/12/02/health/alzheimers-apoe4-gene-therapy.html
Thiago Carvalho
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There is a paper story included into this famous German painting of 1830s from Carl Spitzweg. You may know the common interpretation of the Poor Poet (German: Der arme Poet): Attention to the material misery of most artists and their work!
The painting came in three versions and the one remaining copy is nowadays in the Neue Pinakothek (Munich: https://www.pinakothek.de/kunst/meisterwerk/carl-spitzweg/der-arme-poet ). Let's focus on the paper used and present in this painting.
This is a #PaperHistory especially for #histodons.
1/x
Thiago Carvalho
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RT @KingsImaging@twitter.com
Closing Weds 7th Dec!
Funded PhD opportunities at our Smart Medical Imaging CDT.
Apply Today: https://imagingcdt.com/applications/
#phd #medicalimaging #doctoral
🐦🔗: https://twitter.com/KingsImaging/status/1599714107506446336
'Alphabet-owned Isomorphic Labs is ramping up its operations by poaching pharmaceutical talent and opening a new office, as the artificial intelligence drug discovery start-up moves closer to securing its first commercial deal.
The UK-registered group was spun out of its sister company DeepMind, Google’s AI unit, in November last year, to focus on using AI technology to create new drugs to treat and prevent diseases.'
#DrugDevelopment #DrugDiscovery
https://www.ft.com/content/92ea2434-8d91-49e3-807d-3e425689e749
Thiago Carvalho
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New opinion piece manuscript, awaiting assessment at a [second] journal:
*Alternative reading frames are an under-appreciated source of protein novelty*
Comments, additional references etc. very welcome!! Please reblog if interested in this topic.
https://ecoevorxiv.org/repository/view/4759/
#evolution #MolecularEvolution #MolecularBiology #NewGenes #OverlappingGenes
Thiago Carvalho
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My #Introduction - I am a postdoc doing #Research on #Apoptosis in health and disease, in particular concerning #CardioVascular #Toxicity and #Immunogenic #Celldeath in #CancerTherapy. Transitioning from #HarvardSchoolOfPublicHealth to #UniversityOfGothenburg to start up research on combined #Radiotherapy and #Immunotherapy in #BreastCancer.
#RadioBiology #Cancer #BH3Profiling #Caspases #CardioOncology
Thiago Carvalho
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Are you into genetic screens and small molecule drug discovery? Altos Labs (Cambridge, UK) is looking for a pharmacogenomics enthusiast.
Thiago Carvalho
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"In other words, linking wildlife trafficking to global security helped make states see it as an important problem, but framing it as a security concern made their response much more likely to take the form of militarised anti-poaching operations and other ‘security’ measures rather than actions that attempted to address the structural drivers of the illegal wildlife trade, including economic inequality. Military contractors, of course, have a clear interest in the success of the security paradigm."
Simone Haysom @lrb
https://www.lrb.co.uk/the-paper/v44/n23/simone-haysom/fortress-conservation
Thiago Carvalho
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Don't hesitate to get in touch with any questions... about working in industry, Genentech's awesome compensation package (including bonus + stock options) and benefits, our thoughts on the future of cryoEM/ET in drug discovery and how you could be part of it, etc. Boosts much appreciated!
'As of yet, none of the improved IL-2-based compounds gained regulatory approval for the treatment of cancer or autoimmune diseases. Three compounds treating cancer have entered phase 3 trials with two studies still ongoing. NKTR-214 is the only compound that has completed phase 3 studies.'
#Immunology #Immunotherapy #IL2 #Preprint
https://www.medrxiv.org/content/10.1101/2022.12.02.22283042v1
Thiago Carvalho
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If anyone here interested in further deconvoluting cytokine biology and activity from single cell RNA -Seq data, this looks intriguing... (and promising)
#immunology #sequencing #transcriptomics #singlecell #RNAseq
https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btac775/6865029
Thiago Carvalho
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The amazing @Moatazassem has arrived on Mastodon!
Moataz does super cool work on task-active #brain regions using #fMRI and #ECoG, especially high-res HCP methods. Moataz also has a new #preprint out on the basis of executive functions in fine-grained architecture of cortical and subcortical human brain networks:
https://www.biorxiv.org/content/10.1101/2022.12.01.518720v1
'The last-known Tasmanian tiger died in Hobart’s Beaumaris zoo on the night of 7 September 1936.
“For years, many museum curators and researchers searched for its remains without success,” Dr Robert Paddle, a researcher said.
“No thylacine material dating from 1936 had been recorded in the zoological collection, and so it was assumed its body had been discarded.”
But recent inquiries by Dr Paddle and TMAG curator of vertebrate zoology, Dr Kathryn Medlock, revealed the last-known thylacine’s remains were at the museum.'
Thiago Carvalho
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Newly observed resistance:
Group A Streptococcus found a way to harvest folate from humans, bypassing the inhibitory role of sulfamethoxazole. Hence they are only resistant to the antibiotics when they're causing an actual infection inside our bodies. https://www.sciencealert.com/scientists-just-caught-bacteria-using-a-never-before-seen-trick-to-avoid-antibiotics
'In terms of GDP per capita, it is the EU’s fifth-richest member state. Natural gas accounts for only 2% of its energy, insulating it from the worst economic ravages of Russia’s war on Ukraine. Poverty is far below the European average.
But fast-rising electricity bills and surging food price inflation are taking their toll here as elsewhere. “Sweden also has a poverty problem,” said Johan Rindevall. “We may not talk about it much, but it’s there – and it’s absolutely got worse this year.”
Thiago Carvalho
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Apply to this cool DFG-funded post doc position with @MarthaMerrow at LMU Munich 🇩🇪 on Bacillus subtilis circadian rhythm systems biology if you have experience with microbial transcriptome/proteome👇
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RT @MarthaMerrow
We’re hiring a Post-doc with microbiology and systems biology experience to work on the B. subtilis circadian clock. Super collaboration with @EvolvedBiofilm and @ant_dodd. Apply by 31 Dec. See here for description: h…
https://twitter.com/MarthaMerrow/status/1598742011724664859
Thiago Carvalho
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We're delighted to be at #CellBio2022 this week. Visit booth #1825 to say hello and to learn more about our initiatives
Thiago Carvalho
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#Advent Day5: Another close relative of obscura, #Drosophila subsilvestris was originally described as ‘silvestris’ in 1954 by EB Basden (who hadn’t read his literature) using flies from near Edinburgh http://www.drosophila.jp/jdd/class/030701/03070107.pdf . Dsus is similar to Dobs & Dtri in looks and known ecology, and is common in Scotland—but is harder to keep in the lab. Dsus is our least-studied species so far, with just 12 papers in WOS and its only apparent claim to fame being some B chromosomes https://link.springer.com/article/10.1007/BF00355318
Thiago Carvalho
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Philippe Ganot et al. present an alternative and straightforward method for extracting skeletal organic matrix from a red coral that requires little equipment and saves steps:
journals.biologists.com/bio/article/11/10/bio059536/277219
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
