Thiago Carvalho @cyrilpedia@qoto.org

Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development
https://www.cell.com/immunity/fulltext/S1074-7613(22)00593-3

Glad and relieved to share on mastodon my first co-first work from one of my PhD projects with Eric Miska & Azim Surani. ☺️ Hope it’s a useful one: we team with Giorgia Battsitoni and Greg Hannon to investigate a prior observation of piRNAs in mPGCs in vitro.
Alas, we do not detect piRNAs in Day 6 mPGCLCs. https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00783-3
#piRNAs #GermCells #mPGC #mPGCLC #DevCell #MattersArising

Hello: has any scientist on here abandoned Twitter for Mastodon entirely? I’m looking to speak to you for a story I’m writing

10 startling images of nature in crisis — and the struggle to save it
https://go.nature.com/3iGQcNh

Dendritic cells direct circadian anti-tumor immune responses
https://www.nature.com/articles/s41586-022-05605-0

Welcome to @geffenlab!

Maria is a professor at UPenn who studies hearing and auditory memory. Her lab has discovered a number of new brain circuits that support these important functions: https://hosting.med.upenn.edu/hearing/

Maria is also a polymath who is good at ... basically everything. And she has seemingly endless energy for it. Biotech. Science. Modeling. Advising. +

Let's also applaud Maria's dedication to early career researchers and enhancing diversity:
https://mastodon.social/@geffenlab@mastodon.world/109439093879466275

Follow: @geffenlab

#Crossref is looking to hire a Global #CommunityEngagement Manager. As I was thinking about this role, I came up with a list ... Do you have these characteristics? Come work with us! All the details: https://www.crossref.org/jobs/2022-11-21-community-engagement-manager/ #metaday #werehiring #scholcomms

My latest column for #NatureMedicine is a look at early human results of a new class of #antibiotics for #tuberculosis

The mechanism of action is essentially to clog the #mycobacterium's tRNA synthetase - the result of two decades of research on boron-based compounds.

#IDMastodon #DrugDevelopment
#antibioticresistance

https://www.nature.com/articles/d41591-022-00114-z

We're very excited for our 2023 Meeting 'Infectious Diseases Through an Evolutionary Lens' organised by Wendy Barclay, Sara Cherry, DMM Editor David Tobin @tobinlab & Russell Vance! This will take place on 17 - 19 October in London and we hope to create a collaborative environment for you to share your work and for your ideas to grow!

Register for updates on registration:
https://biologists.com/meetings/dmminfectious2023

Day 5 of #ArtAdventCalendar.

Back to sharing another #Cyanotype print. A bit blurred at the left edge. But to the rest of the detailed sheet also a welcome contrast. The overlapping parts of the sheet are what make it so interesting. Borderless prints are always a challenge to handle.

#CyanoPrint #Cyanotypie #SunPrinting #SunPrint #FloralCyanotype #ArtOnMastodon #ArtistsOnMastodon #ArtOnMasto #MastodonArt #MastoArt #Art #CyanotypeArt #AdventCalendar #Advent #MyArt

A doorway in Lisbon, somewhere near the castle.
#portugal #TravelPhotography #rx100 #europe #derelict #architecture

⚠️ Danger ahead – trust your gut feeling!

#Metabolites from pathogenic #bacteria trigger a #stress response in the worm’s #gut

https://prelights.biologists.com/highlights/olfactory-chemosensation-extends-lifespan-through-tgf-%ce%b2-signaling-and-upr-activation/

Great #preLight from #CheeKiangEwe who covers a #preprint from the Taylor lab #MRCLMB. Includes an author's response 📝

#paidsickleave is #publichealth issue. 1/

https://nymag.com/intelligencer/2022/11/rail-strike-why-the-railroads-wont-give-in-on-paid-leave-psr-precision-scheduled-railroading.html?fbclid=IwAR3NCfyjIC4Bdxud4UpkuuSdj09ZhX7NP2VswCRf7CadvZRxBsneA-taaPQ

TDF (#tenofovir disopropoxil fumarate) is a cheap, safe antiretroviral to treat and prevent #HIV.

#Observational studies have found that TDF users have a much lower risk of severe #COVID19 than users of other antiretrovirals (including TAF, another tenofovir prodrug).

How come no randomized trials of TDF exist? If interested in the repurposing of known antivirals to prevent serious #COVID19, watch my talk here

https://play.ki.se/media/Miguel+Hern%C3%A1n+-+22+03+2022/0_ge5wg9fm/373731

Links to the 2 most recent studies (just published) below.

New #cryoET structure from LSI Exeter colleagues Matthew Gaines et al. Bertram Daum lab, this time of the enigmatic #archaeal filament called 'thread'.

What I find cool about this work is that first they had the structure, then found the sequence based on glycosylation sites and bulky residues.
This #protein was also so ultra-stable, that resisted trypsinisation, so mass spec was not an option to identify it.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715654/

Check out our recent paper on #vascular cell apoptotic vulnerabilities to #cancer therapeutics, including #radiotherapy, #chemotherapy and targeted agents (e.g. #proteasome inhibitors, #BH3mimetics). We find that #EndothelialCells remain primed for #apoptosis throughout development into adulthood and may represent a “weakest link” vulnerability in multiple tissues for development of toxicities. https://www.science.org/doi/full/10.1126/sciadv.abn6579

#Celldeath #CardioOncology #VigiBase #RadioBiology #BH3Profiling