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'However, beyond emergence, there is little information regarding whether developing HSCs respond in utero to maternal inflammation, how they respond, and the consequences for postnatal hematopoietic and immune development. We hypothesize that the fetal HSC response to prenatal inflammation drives lasting changes to hematopoietic output in offspring that shapes the postnatal immune response.'

cell.com/cell-reports/fulltext

Villa Vespa is a crumbling building in Italy, with frescoed walls and ceiling. In the middle of the room is an old blue scooter.

Explore more photos from this abandoned location : obsidianurbexphotography.com/r

#Photography #PhotoOfTheDay #Urbex #AbandonedPlaces

Come do awesome science and learn with me!

I have a PhD position available to study the effects of variation on miRNA targeting.

* Why does mutating miRNA sites not always have an effect on the target?
* Why does varying miRNA level not affect the levels of all targets?

#PhDstudent #ScienceJobs

Do you want to go to the Evolution meeting in 2023? Do you live outside of a high GDP country? Check out @eseb 's conference travel award! eseb.org/prizes-funding/confer

"Together with other Africa-derived BA.1-like sequence entries, the Omicron ancestors clustered in basal sister relationship between the Omicron clade sensu strictu, the BA.1 sublineage and Omicron ancestors belonging to the globally circulating B.1 lineage (Fig. 3, A and B). Phylogeographic analyses supported BA.1 origins in Western Africa preceding spread in Southern Africa (fig. S4), which was consistent with the PCR-based data (table S2)."

science.org/doi/10.1126/scienc

💫Important clinical study by J. Haanen & colleagues @NKI_nl out in @NEJM reporting on the efficacy of TIL therapy with a response rate of 49% (TILs) vs 21% (ipi) also in checkpoint inhibitor (a-PD1) refractory melanomas.

💫Beautiful accompanying editorial by @CoukosGeorge.
1/n

In which & meet &

'The notion that development is plastic—i.e. malleable in response to environmental, genetic or stochastic perturbations—is not something that will surprise epidemiologists, although the terminology may not be a familiar one. Indeed, epidemiology is concerned almost exclusively with ‘plastic’ processes, with the reliable identification of exposures that lead to modification of disease risk through such processes being of central concern.'

academic.oup.com/ije/article/4

Expanding the HDAC druggable landscape beyond enzymatic inhibition.

Creative use of yeast genetics and chemical screens to target transcriptional co-regulatory surfaces conserved across the tree of life all the way to humans.

biorxiv.org/content/10.1101/20

I am looking for a PhD student in the MRC AIM Doctoral Training Programme on the project 'The gut phageome as a driver for microbiome dynamics in critically ill patients', a collaboration with
Andy Millard of the University of Leicester

more.bham.ac.uk/mrc-aim/phd-op

Let me know if you have questions.

Deadline 09:00 GMT, Monday 16 Jan 2023

I joined @QueerTalk to chat about my Broadway musical ‘Allegiance’ soon to be playing in London. It’s a story about love, family, and heroism during a dark chapter of American history.

Spotify: spoti.fi/3YabNxV
Apple: bit.ly/3hbwn0m
Amazon: amzn.to/3Ff2Nzb

We want you to transfer our knowledge‼️

Position:
Knowledge transfer coordinator

Application deadline:
December 15, 𝟮𝟬𝟮𝟮

Further Informationen:
mdc-berlin.de/career/jobs/know
#mdcBerlin @BIMSB_MDC

portal.uni-koeln.de/en/univers

🧬 A new consortium in :koeln: focussing on the (patho)physiological consequences of genome instability led by Bjoern Schumacher @schumacherbj and Stephanie Panier.

:happy: Proud and grateful to be part of this! :beamingFace:

🙏 A huge THANK YOU to Bjoern, Steffi, and everyone else in the enterprise!

Stability is what we need 😉

@CECAD @MPIAGE @UniKoeln
#DFG #FOR5504 #UniklinikKöln

RT @vervaeke_john
I recently joined @DeBeaudoir on her podcast "Planet: Critical" in an episode titled "Making Sense of the Meaning Crisis." We discuss the impact that the meaning crisis is having on individuals all around the world and what to do about it.

Listen here: ow.ly/xmKs50LYBhw

"Always highlight the global repercussions of every local crisis, and the interconnectedness of all people. Avoid hysteria based on otherness and understand that incremental progress can have tremendous impact. At the same time, don’t assume populations of low- and middle-income countries accept lower health and life standards than those living elsewhere."

qz.com/10-best-practices-for-e

Aneuploidy, the gain or loss of chromosomes, can cause birth defects, miscarriage, #cancer predisposition and age-related disorders.

In a brand new review, Nicholas Baker from Albert Einstein College of Medicine and Cristina Montagna from Rutgers Cancer Institute of New Jersey discuss evidence that #aneuploid cells are eliminated in the presence of normal cells and the potential role of ribosomal protein #gene #haploinsufficiency.

journals.biologists.com/dmm/ar
#OpenAccess #CellCompetition

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