Thiago Carvalho @cyrilpedia@qoto.org

For our lab's weekly journal club covering classic papers in immunology, we discussed Zheng and Flavell's discovery of GATA3 as a critical transcription factor for Th2 cell cytokine expression.

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells. Cell, 1997.

Before microarray or RNA-seq, there was cDNA subtraction by representational difference analysis.

#Immunology

https://www.cell.com/action/showPdf?pii=S0092-8674%2800%2980240-8

Rifamycin based TB preventative therapy associated with less adverse events.
#IDMastodon #MedMastodon #TB #tuberculosis #antibiotics

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad246/7147456?utm_source=advanceaccess&utm_campaign=cid&utm_medium=email&nbd=39370074470&nbd_source=campaigner

#Gasdermins (GSDMs) are pore-forming proteins involved in #CellDeath & #inflammation. @jianbin_ruan explores a #PLOSBiology study of the evolution of GSDMs in metazoa, highlighting the role of GSDME in #pyroptosis. Primer: https://plos.io/3nyd4By Paper: https://plos.io/3p6klcm

The cilium–centrosome axis in coupling cell cycle exit and cell fate

In their Opinion article, @priti_atmakuru and Jyotsna Dhawan discuss the role of the cilium-centrosome complex in tissue homeostasis.

https://journals.biologists.com/jcs/article/136/9/jcs260454/308872/The-cilium-centrosome-axis-in-coupling-cell-cycle

Focussing on the past, the present and the future

Check out the latest in all things FocalPlane in our Editorial from @helenzsci and @seemasainson published in @J_Cell_Sci!

We look back over the three years since FocalPlane was launched and look forward to some exciting projects in 2023 and beyond, including working with our #FocalPlaneCorrespondents.

https://focalplane.biologists.com/2023/05/03/focussing-on-the-past-the-present-and-the-future/

Whoa. Let’s get back to rationale discussions in brain research:

Debate is vital … The discussion that followed … this is a shame ….

https://www.thelancet.com/pdfs/journals/lanpsy/PIIS2215-0366(14)70363-3.pdf

'Writing in Nature, Krishna et al.2 show that malignant gliomas can grow by modifying brain circuitry, thus taking cognitive function away from their host and ultimately leading to death. These insights might lead to fundamentally new approaches to glioma treatment and provide a means of limiting cognitive decline in affected individuals.'

https://www.nature.com/articles/d41586-023-01387-1

'We demonstrate that while male NK cells display enhanced cellular fitness in mice, they show decreased effector function in mice and humans. These sex biases in NK cell composition and function were not completely due to hormonal differences, because they persisted in gonadectomized mice'

#Immunology #InnateImmunity #NKcels

https://www.nature.com/articles/s41590-023-01463-8

@ct_bergstrom

2. There is a very honest description of scientists' motivations. We are all "epistemically sullied", motivated by both curiosity AND desire for recognition.

It is critical to acknowledge this as we seek to reenvisage publishing. Denying the fact (how it drives pursuit of JIF, CNS, h index, competition, etc.) won't help us. The key is to understand this and then think how the system can be improved so distortions (Goodhart's Law, etc.) are minimized.

3/3

This is exciting:
"...In this Article, we show that gut-specific telomerase expression in tert−/− zebrafish is sufficient to delay gut aging. Counteracting gut aging improves health of the entire organism, reverting gut microbiota dysbiosis and aging phenotypes in distant organs of tert−/− zebrafish"
https://rdcu.be/dbo2E

Interplay Between Polymorphic Short Tandem Repeats and Gene Expression Variation in Caenorhabditis elegans https://doi.org/10.1093/molbev/msad067 #science #evolution #biology #genome #SciComm #evolgen_paper

"A "very concerning" rise in the number of people catching measles in the UK has been reported by health officials.

The virus spreads incredibly easily and a fall in vaccination rates is leaving more children vulnerable."

Get Vaccinated.
#VaccinesWork
https://www.bbc.co.uk/news/health-65481976

@ct_bergstrom

1. There's a great explanation of the oft-cited Why Most Published Research Findings are False paper by John Ioannidis that explains why assumptions made about how scientists general hypotheses mean this is not correct.

Others have pointed this out but Carl and Jevin give a very clear explanation of why, which is important given how frequently and uncritically this work is cited in our sphere 2/3

Calling Bullshit by @ct_bergstrom is a fascinating read that brilliantly summarizes issues around data interpretation, various logical fallacies, phony graphs, and misleading statistics.

That alone makes it essential reading but two other things stood out for me that may interest sci comm/publishing types. 1/3

90% of cancers reactivate telomerase. In our new preprint, we reveal that tumors that fail to activate telomerase trigger a stronger immune response, leading to melanoma regression. Our work also sheds light on the association between telomerase gene mutations and the immune system and provide a mechanism to explore the success of immunotherapies.

🐟 #zebrafish 🧬#telomerase 💊#immunotherapy 🔬#cancerresearch https://www.biorxiv.org/content/10.1101/2023.03.24.534079v1