Thiago Carvalho @cyrilpedia@qoto.org

'We find that naïve-like T cells in zebrafish organize into a previously undescribed whole-body lymphoid network that supports streaming migration and coordinated trafficking through the host. This network has the cellular hallmarks of a mammalian lymph node, including naïve T cells and CCR7-ligand expressing nonhematopoietic cells, and facilitates rapid collective migration.'

https://www.pnas.org/doi/10.1073/pnas.2301137120

Provence.

Finally, a solution to the unfairness of authorship ordering in scientific papers! 😂

"Every Author as First Author"

https://arxiv.org/abs/2304.01393

Potentially good news that the EU is considering to move beyond #OpenAccess mandates and do away with author publication fees - and fund scientific publication directly.

https://www.researchprofessionalnews.com/rr-news-europe-infrastructure-2023-5-eu-ready-to-back-immediate-open-access-without-author-fees/

To me, one problem in the way we talk about this is the tendency to discuss "journals" as a monolithic entity. On a previous episode of the #EMBOPodcast Adriano Aguzzi, Thomas Lemberger & I discussed if funding agencies should establish stricter parameters for which journals could be funded. The community can rate what matters - this is the sort of thing that could give DORA principles some teeth for example. Quality peer review, track record of publishing reliable work, inclusivity, tools for data analysis, etc.
If you want to jump to this bit in the episode ("From Prions to Preprints"), go to minute 19.

https://www.embo.org/podcasts/from-prions-to-preprints/

'Even within one rare disease, many subtypes can exist that require personalized approaches to therapy. As one example, EMA’s chief medical officer Steffen Thirstrup mentions cystic fibrosis, which affects around 1 in 2,500 babies born. “When I left medical school 30 years ago, we knew that cystic fibrosis was caused by a genetic defect, but now we know that different mutations in the genome can cause this disease,” he explains.'
#raredisease

https://www.nature.com/articles/s41591-023-02333-4

'Many experts welcomed the Lilly data as an important step forward but cautioned that donanemab was not a cure and the full results of the trial have not yet been published and need to be closely studied.'

https://www.ft.com/content/b18aefc1-ccbc-442e-a23c-117f27826d71

@NicoleCRust and the short! https://youtu.be/7tScAyNaRdQ

They're made out of meat
Terry Bisson, 1991. Sci-fi at it's best.

“They actually do talk, then. They use words, ideas, concepts?”
“Oh, yes. Except they do it with meat.”
...

Delightful read:
http://www.terrybisson.com/theyre-made-out-of-meat-2/

#scifi #neuroscience

'In this Essay, we discuss recent findings related to changes in the metabolic functions of immune cells (immunometabolism), particularly mitochondrial dysfunction, in innate and adaptive immune cells and their contribution to the generation of autoimmunity, with emphasis on systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)'

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002084

Provence