Great discussion of one my favorite authors, #ItaloCalvino & democracy.
"David talks to Ian McEwan about Italo Calvino’s The Watcher (1963), one of the greatest of all works of political fiction."
Potentially good news that the EU is considering to move beyond #OpenAccess mandates and do away with author publication fees - and fund scientific publication directly.
To me, one problem in the way we talk about this is the tendency to discuss "journals" as a monolithic entity. On a previous episode of the #EMBOPodcast Adriano Aguzzi, Thomas Lemberger & I discussed if funding agencies should establish stricter parameters for which journals could be funded. The community can rate what matters - this is the sort of thing that could give DORA principles some teeth for example. Quality peer review, track record of publishing reliable work, inclusivity, tools for data analysis, etc.
If you want to jump to this bit in the episode ("From Prions to Preprints"), go to minute 19.
'Even within one rare disease, many subtypes can exist that require personalized approaches to therapy. As one example, EMA’s chief medical officer Steffen Thirstrup mentions cystic fibrosis, which affects around 1 in 2,500 babies born. “When I left medical school 30 years ago, we knew that cystic fibrosis was caused by a genetic defect, but now we know that different mutations in the genome can cause this disease,” he explains.'
#raredisease
"In that reality of hyper-concentrated power and wealth, AI – far from living up to all those utopian hallucinations – is much more likely to become a fearsome tool of further dispossession and despoilation."
"Achieving a 50% reduction in cancer mortality in 25 years will be impossible without addressing cancer health equity. Many populations experience health inequities, including people from some racial and ethnic minority groups, people with disabilities, women, people who are LGBTQI+ (lesbian, gay, bisexual, transgender, queer, intersex, or other), people with limited English proficiency, and people living in rural location"
'The EU is ready to agree that immediate open access to papers reporting publicly funded research should become the norm, without authors having to pay fees, and that the bloc should support non-profit scholarly publishing models.'
@biorxivpreprint The here proposed relevant link between an neoepitope-dependent equal recognition by CD4+ and CD8+ T cells and positive response to #immunotherapy should be easily tested for confirmation in clinical samples from #vaccination trials, e.g. in #melanoma or #headneckcancers patients...but why have those one-vaccine-for-all-patients trials not shown positive results: no CD4+/CD8+ induction? Or no good neoepitope? Both? Else? @cyrilpedia @CastlTrAstonDrs @rio_sugimura
'Similarly, the C.D.C.’s budget process is byzantine. It has about 160 individual budget lines, and little to no ability to move funds to where they are needed in a crisis. That is not how FEMA and the Department of Defense operate amid a crisis. Congress has the power to grant the C.D.C. the essential flexibility it requires, and it should.'
https://www.nytimes.com/2023/05/07/opinion/cdc-overhaul.html
'Arthur Bispo do Rosario, a former Marine Corps signalman, boxer, tram cleaner and domestic worker in Rio de Janeiro, had no interest in defining his extensive activities as art. His unusual embroidered garments and textiles, ingenious assemblages and use of language had a higher purpose: Bispo was Jesus Christ, according to angels who visited him the night of Dec. 22, 1938, and instructed him to record, or possibly replicate reality. Thus, the title of his first retrospective in the United States, at the Americas Society in Manhattan: “Bispo do Rosario: All Existing Materials on Earth.”
https://www.nytimes.com/2023/05/05/arts/design/bispo-do-rosario-brazilian-artist.html
'Many experts welcomed the Lilly data as an important step forward but cautioned that donanemab was not a cure and the full results of the trial have not yet been published and need to be closely studied.'
https://www.ft.com/content/b18aefc1-ccbc-442e-a23c-117f27826d71
Spindle in dividing cells,
single when it sleeps.
Bids goodbye in fusing cells,
so many secrets to reveal!
Our Opinion on the cilium-centrosome axis buzzing with activity during fate choice! Now @J_Cell_Sci
#cilia #centrosomes #centriolarsatellites #RNA
https://journals.biologists.com/jcs/article-abstract/136/9/jcs260454/308872/The-cilium-centrosome-axis-in-coupling-cell-cycle?redirectedFrom=fulltext
Protein Engineering for Thermostability through Deep Evolution | https://www.biorxiv.org/content/10.1101/2023.05.04.539497v1.full.pdf+html #proteomics
'Só em Portugal é que isto poderia acontecer. Há uma crise política que ameaça a continuidade do Governo, mas quem pode acabar por cair é o líder do principal partido da oposição.'
https://www.publico.pt/2023/05/08/opiniao/opiniao/marcha-funebre-montenegro-entrada-passos-2048785
@NicoleCRust It's great if people can do research and are great communicators. But it should not be assumed, or required, to be the case in my opinion. A lot of funders are just tossing in mandates for SciComm in grants that I think are very inappropriate. We discussed this a bit on the #EMBOPodcast with Maria Leptin & Fiona Watt (after min 24) https://www.embo.org/podcasts/i-learned-early-on-that-you-can-do-a-lot-with-a-small-amount-of-money/
The East River, by @madparreira
#Print #Printmaking #handmade #printmakingart #artgallery #artmastodon
@CastlTrAstonDrs Not only relevant for #breastcancer but also for #colorectalcancer and more...central not only to bone metabolism but also relevant for the immune system...so consider Vit D levels in #cancer patients, even if they are exposed to the sun daily... @cyrilpedia #immunology
@biorxivpreprint Modulation of immune surveillance occuring during metastatic progression is still a major issue in #cancer #Immunology...and a recurring "smoking gun" are #macrophages and other #myeloidcells ...also here in this experimental model that uncovered a TLR-NFκB myeloid inflammatory program which correlates with pre-metastatic #niche formation and reflects similar signatures of CD14+ 'activated' myeloid cells in the primary tumor @cyrilpedia
The sawfly Athalia bicolor—splendid http://www.inaturalist.org/observations/160368408
#iNaturalist #Hymenoptera #sawflies #entomology #insects #MacroPhotography
The East River, by @madparreira
#Print #Printmaking #handmade #printmakingart #artgallery #artmastodon
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com