Thiago Carvalho @cyrilpedia@qoto.org

Yet another study showing that tumor mutation burden is a poor predictor of response to checkpoint blockade.

"First we assembled the largest pan-cancer dataset of immunotherapy patients with sequencing and clinical data. Surprisingly, we find little evidence that TMB is predictive of response to ICB.
(...)
Our analysis shows that the use of TMB in clinical practice is not supported by available data and can deprive patients of treatment to which they are likely to respond."
#Immunology #immunooncology #immunotherapy

https://elifesciences.org/reviewed-preprints/87465

“It’s stunning,” says the immunologist Barney Graham, the former deputy director of the Vaccine Research Center and a central figure in the development of mRNA vaccines, who has lately been writing about a “new era for vaccinology.” “You cannot imagine what you’re going to see over the next 30 years. The pace of advancement is in an exponential phase right now.”

https://www.nytimes.com/2023/06/23/magazine/golden-age-medicine-biomedical-innovation.html

Postdoctoral Researcher – Ellerby lab

Buck Institute for Research on Aging

#Ellerby lab at #Buck seeks a #Postdoc Scientist experienced in stem cells, neurodegenerative diseases & mouse models.

See the full job description on jobRxiv: https://jobrxiv.org/job/buck-institute-for-research-on-aging-27778-postdoctoral-researcher-ellerby-lab/?feed_id=48495

#ScienceJobs #hiring ...
https://jobrxiv.org/job/buck-institute-for-research-on-aging-27778-postdoctoral-researcher-ellerby-lab/?feed_id=48495

In those without a #COVID19 history, similar antibody production was reached 45 days after vaccination. Although total antibodies decline considerably in the first 2 months, the neutralizing antibodies & their inhibitory capacity (>96%) persist up to 6 months after the first dose of #BNT162b2 @Vaccines_MDPI
📌 https://www.mdpi.com/2076-393X/11/6/1127
📌 https://www.mdpi.com/journal/vaccines/special_issues/vaccines_antibody

#OTD 26 June 1925 Jean Frydman was born. A French Jew, he became active in the Resistance & even escaped a deportation train to Buchenwald. He was a peace advocate who helped negotiated the Oslo Peace Accords 1993 between Israel & Palestine. He died in 2021 at the age of 95.

AlphaFold and the future of structural biology
https://scripts.iucr.org/cgi-bin/paper?me6231

#StructuralBiology @strucbio #AlphaFold

Follow @TexasObserver’s coverqge on the larger aftermath of the Dobb ruling, one year later: https://www.texasobserver.org/topics/public-health/

Referenced link: https://www.nature.com/articles/s42255-023-00829-4.epdf
Discuss on https://discu.eu/q/https://www.nature.com/articles/s42255-023-00829-4.epdf

Originally posted by Nature Portfolio / @NaturePortfolio: http://nitter.platypush.tech/NaturePortfolio/status/1673368796319432704#m

Pairing exercise with a diet-induced weight-loss intervention leads to greater improvement in insulin sensitivity and glucose control than dieting alone in people with obesity and prediabetes, according to a clinical trial published in @NatMetabolism. https://www.nature.com/articles/s42255-023-00829-4.epdf

Last year, we failed to replicate some key experimental results in an extraordinary @eLife paper. Our results, the authors' response, and a correction to the original paper are now published.

https://elifesciences.org/articles/84435
https://elifesciences.org/articles/85370
https://elifesciences.org/articles/90007

My opinion is that the original paper is flawed and should be retracted, but now @eLife readers can hear from both sides and decide for themselves.

Watch Footage of Claude Monet Painting in His Famous Garden at Giverny (1915)

https://www.openculture.com/2023/06/watch-footage-of-claude-monet-painting-in-his-famous-garden-at-giverny-1915.html

#IDMastodon #Viralimmunity @cdcgov
Never too late to get #COVID19vaccines & 😷 #CovidIsNotOver
In this finding Antibodies to the spike protein develop after vaccination or infection and can take a relatively long time to decrease, but antibodies to the nucleocapsid protein develop only after natural infection and wane at a faster rate, which is particularly detectable with testing by using an IgG assay format vs a total antibody assay format

Targeting FGF21 & GLP-1 pathways in NASH. My latest Clinical Pipeline column for Nature Medicine is online.

#drugdiscovery #drugdevelopment #metabolism #LiverDisease #fattyliver

https://www.nature.com/articles/d41591-023-00055-1

Boehringer moves forward with its glucagon/GLP-1 receptor dual agonist, survodutide.

"The German drugmaker is now preparing to launch a late-stage trial of its drug, which if approved, would compete with Eli Lilly’s Mounjaro and Novo Nordisk’s Wegovy. US pharma group Pfizer and biotech Regeneron are among the others hoping to enter the market."

#Metabolism #Pharma #DrugDevelopment #DrugDiscovery #Obesity

https://www.ft.com/content/d3f5e936-05af-4775-8247-cff1c007ba45

"After leaving the field in disgrace, Dr. Hwang has landed in clover, and now spends his days cloning beauty show and racing camels for United Arab Emirates royalty."

https://www.nytimes.com/2023/06/21/opinion/cloning-science-fraud.html

Copying Donatello (no, not the turtle).

"Starting with a pencil sketch before working with a series of ever-finer tools to ‘nibble away’ at the stone, Smith offers an immensely satisfying glimpse into how one of history’s great sculptors created dazzling, emotive scenes from just stone, shadow and light."

https://aeon.co/videos/from-a-pencil-sketch-to-cherubs-dancing-in-stone-recreating-a-donatello-work

'Gramsci es el pensador fundamental para entender por qué mandan los que mandan y por qué obedecen los que obedecen.'

https://elpais.com/ideas/2023-06-25/los-diez-pensadores-que-mas-influyen-en-la-izquierda.html

#OTD 26 June 1913 Aimé Césaire was born. He became an anti-colonial author & politician who coined the word 'négritude.' He founded the Parti progressiste martiniquais in 1958 & served in the French National Assembly from 1958 to 1993.