Thiago Carvalho @cyrilpedia@qoto.org

'Using a version of OpenAI’s GPT-4 program through Microsoft’s Azure cloud service, the researchers found that a tailored generative AI application was able to quickly comb through patient notes within electronic medical records and accurately identify those with heart failure who met the criteria for a study.'
https://www.fiercebiotech.com/medtech/study-shows-generative-ai-can-speed-clinical-trial-enrollment-pennies-patient

"Among the 247,854 COVID-19-related papers published in PubMed, 12,152 were initially released as preprints and were eventually published in 1,380 journals. This number is more than five times the 246 journals to which submissions can be made directly from bioRxiv through the B2J program. Journals with higher impact factors and Normalized Eigenfactor scores tend to publish a larger number of preprint-derived articles"
https://www.biorxiv.org/content/10.1101/2024.05.28.596359v1

'De pouquíssimos intelectuais públicos se pode dizer que estão em condições de comemorar em vida os 85 anos do seu primeiro artigo político. Mas é o caso de Chomsky: foi em 1939, tinha ele dez anos, que publicou um primeiro artigo político no jornal da sua escola, em Filadélfia, sobre a Guerra Civil de Espanha.'
@ruitavares
https://expresso.pt/opiniao/2024-06-20-a-semana-em-que-chomsky-nao-morreu-2f332ce5

'We find that diapause evolved by a recent remodeling of regulatory elements at very ancient gene duplicates (paralogs) present in all vertebrates. CRISPR-Cas9-based perturbations identify the transcription factors REST/NRSF and FOXOs as critical for the diapause gene expression program, including genes involved in lipid metabolism.'

https://www.cell.com/cell/fulltext/S0092-8674(24)00474-4

Tasty, but often lacking in nutritional value:
"First, there is Causal Salad: You put everything into a regression equation, toss with some creative story-telling, and hope the reviewers eat it. In general, this is not a valid approach, for well-known reasons. But it can get you published. Causal salad can discover causes too. But you have to get lucky. The Salad isn’t only regression. Really any procedure that hopes to take a list of variables (features) and return causal inference is Causal Salad. No amount of data reliably turns salad into sense."
https://elevanth.org/blog/2021/06/15/regression-fire-and-dangerous-things-1-3/

'Há, no entanto, em especial, um grupo que escapou à penalização do seu papel na ditadura: os juízes dos Tribunais Plenários. Esses juízes eram serventuários da PIDE, exactamente serventuários, impediam qualquer simulacro de julgamento e de lei'

https://www.publico.pt/2024/06/22/opiniao/opiniao/justos-avancam-ofensiva-politica-impuros-2094868

É necessário e urgente garantir condições dignas e humanas de acolhimento a refugiados e migrantes em todos os pontos de entrada no país, com tempos de resposta curtos para situações temporárias. 🧵

Não podemos ter um modelo de Portugal Fortaleza, que condena os refugiados e migrantes a situações de imensa fragilidade e capturáveis pelas redes de tráfico humano.

Curious about the organization of AI4Life? Find out how the project is structured and discover who's guiding it by visiting our new Governance page: https://ai4life.eurobioimaging.eu/governance/

O LIVRE defende, em Portugal e na União Europeia, medidas que façam garantir os Direitos Humanos, de solidariedade e que garantam condições de segurança para todas as pessoas que desejam refazer as suas vidas.

Safety, Efficacy, and Pharmacokinetics of SHR-A1811, a Human Epidermal Growth Factor Receptor 2–Directed Antibody-Drug Conjugate, in Human Epidermal Growth Factor Receptor 2–Expressing or Mutated Advanced Solid Tumors: A Global Phase I Trial

https://ascopubs.org/doi/10.1200/JCO.23.02044

'Patients with liver metastases derive limited benefit from immunotherapy independent of other established biomarkers of response. In multiple mouse models, we show that liver metastases siphon activated CD8+ T cells from systemic circulation. Within the liver, activated antigen-specific Fas+CD8+ T cells undergo apoptosis following their interaction with FasL+CD11b+F4/80+ monocyte-derived macrophages.'
#Immunology
https://www.nature.com/articles/s41591-020-1131-x

'The book is also something of a diptych. The resonances between the two greatest public-health crises of Fauci’s tenure at niaid are impossible to ignore. Both cases involve asymptomatic infection, a scramble for tests and treatments, public-information campaigns, and the search for a vaccine—miraculously fast for covid-19, still unfulfilled for H.I.V. '
https://www.newyorker.com/magazine/2024/06/24/on-call-a-doctors-journey-in-public-service-anthony-fauci-book-review

'Then, in the winter, the administrator sent out an email to all of us writers, saying that they had some extra funding available to provide food and drinks to anyone who wanted to start a club of some kind. I thought back to my Joyce class at Oxford, and I wrote back, half-kidding, to ask if they’d pay for some Guinness and Jameson whiskey if I started a James Joyce Reading Group.'
https://lithub.com/a-book-club-of-two-the-time-i-started-a-james-joyce-reading-group-in-college/

'After a few years of seeing Kerouac’s byline in print, the thinking went, readers would pay attention when they recognized his name on the cover of On the Road. It was one of the first literary “debuts” of its kind, explains Temple University professor Laura McGrath, author of the forthcoming book Middlemen: Literary Agents and the Making of Contemporary American Literature. McGrath argues that Sterling Lord created the blueprint for the literary “debut” phenomenon we still see today.'
https://www.esquire.com/entertainment/books/a60924704/debut-fiction-challenges/

An All-Ireland Diamond Open Access Publishing Platform?

Here's a report on an interesting development about Open Access in Ireland. The article belongs to the Special Issue 10th Anniversary Special Issue "PUBMET2023 Conference on Scholarly Communication in the Context of Open Science" and has the following abstract: The Government of Ireland has set a target of achieving 100% open access to publicly funded scholarly publications by 2030. As a key element of achieving…

http://telescoper.blog/2024/06/24/an-all-ireland-diamond-open-access-publishing-platform/

Turns out there is one single observation of Spilomyia graciosa – a wasp-mimicking hoverfly, a #Syrphidae – in the whole of #iNaturalist, from 2021, and that it was done by myself. The colored pattern on the eyes is wild:

https://www.inaturalist.org/taxa/717804-Spilomyia-graciosa

#Diptera #entomology #insects #flies