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#Pfizer is working on an improved replacement for #Paxlovid. The new drug, #Ibuzatrelvir, has completed Phase II trials. Two significant advantages: it doesn't contain ritonavir, so it won't mess up dosages of other drugs the patient is taking, and doesn't produce a bitter or metallic taste.

#COVID19 #CovidIsNotOver #medicine

science.org/content/blog-post/

'Meanwhile, since 2005, more than two thousand dogs have been successfully cloned. Biologically, their genesis is not very different from that of cloned cows or sheep, but in other respects the cloning of pets is far more uncanny.'
newyorker.com/magazine/2024/07

The EU plans to boycott Hungary's foreign policy summit due to Prime Minister Orban's actions, reports Politico. Brussels is considering this unprecedented step because of Orban's opposition to the EU's normal operations and foreign policy. Instead of attending the summit in Budapest, EU foreign ministers intend to organize their own foreign affairs summit in August. politico.eu/article/hungary-bo

'(...) Enger was later arrested and sentenced to six years and three months, Norway’s longest-ever stretch for theft. Hill joked: “‘The Scream’ was stolen by a bunch of Oslo no-hopers. I suppose you could say it was Norwegian organised crime: two men and a ladder.”

ft.com/content/30c7f586-e3bd-4

@cyrilpedia you got to appreciate this little gem . I'm assuming an aptronym, but could be a zombie...

#TimothySnyder : Political Violence: Reflections from the 1920s and 1930s

"Nothing in recent American political life resembles Trump’s call for “Second-Amendment people” to kill Hillary Clinton, his mockery of Paul Pelosi after an attempted murder, his belittling of Gretchen Whitmer after a kidnapping attempt, the stochastic violence he directs against critics to intimidate them and against his fellow Republicans to keep them in line..."

snyder.substack.com/p/politica

'Lisbon-based Somai Pharmaceuticals, which is involved in the extraction, development and distribution of medical cannabis products, is seeking €250mn as a “reasonable” valuation in a Nasdaq IPO, with a secondary listing on the Toronto Stock Exchange or the LSE, said chief executive Michael Sassano.'

ft.com/content/e5e099b5-d7c9-4

'Isto em nada implica descurar a investigação básica, cujos resultados são impossíveis de prever, e que é fundamental precisamente por isso. Mas que deve ser, além de apoiada, devidamente explicada. Sobretudo, explicada de maneira a envolver a comunidade, não usando um tom professoral para recetores passivos, algo que em comunicação de ciência se designa por “modelo do défice”. Por mais boa vontade que se tenha, há sempre a sensação de alguma arrogância neste tipo de iniciativas, que pode afastar as pessoas a quem se dirige, acabando por cristalizar numa bolha que inclui apenas os já convertidos.'
publico.pt/2024/07/15/ciencia/

I’m preparing a talk on women who shaped Western #ScienceCommunication and just listened to this fabulous #podcast episode all about #JaneMarcet (who I’m using as one of my case studies 👩‍🔬). Marcet was keen on making complex ideas accessible for everyone (including ‘the ladies’!), all starting with her “Conversations in Chemistry” #science novel. This pod is very much worth a listen 🤩 podcasts.apple.com/au/podcast/

'Global vaccine coverage has yet to return to 2019’s levels, before the Covid-19 pandemic disrupted immunisation programmes. That year, 12.8 million children were classed as “zero-dose” and a further 5.5 million as under-vaccinated.

More than half of the world’s zero-dose children live in 10 countries, which officials said were “a mix of those with large birth cohorts, weak health systems or both”'

theguardian.com/global-develop

Assistant Professor in Global Change Biology

Texas Tech University

The Department of Biological Sciences in the College of Arts and Sciences at Texas Tech University invites applications for a 9-month, tenure-track, A

See the full job description on jobRxiv: jobrxiv.org/job/texas-tech-uni

#ScienceJ...
jobrxiv.org/job/texas-tech-uni

'Twenty-nine different Car-T treatments for autoimmune diseases, ranging from the muscle inflammation condition myositis to multiple sclerosis, are now being tested in clinical trials by drugmakers including Novartis and Bristol Myers Squibb'

ft.com/content/a974f4c1-bb8a-4

'Apesar da retórica popular, a União Nacional (RN) opôs-se ao aumento dos salários médios e mínimo, optando por propor a redução das contribuições para a Segurança Social, e defendeu menos regras ambientais. Como nos anos 30, a chegada dos fascistas ao poder teria o amparo do dinheiro.'

expresso.pt/opiniao/2024-07-11

'Correlation is not causation: this simple and uncontroversial statement has far-reaching implications. Defining and applying causality in biomedical research has posed significant challenges to the scientific community. In this perspective, we attempt to connect the partly disparate fields of systems biology, causal reasoning, and machine learning to inform future approaches in the field of systems biology and molecular medicine'

embopress.org/doi/full/10.1038

A guy on Facebook reported one of my #COVID19 posts as misinformation, saying that masks have been proven to be ineffective at preventing infections. If you are laboring under the same delusion:

Masks Work. Distorting Science to Dispute the Evidence Doesn’t - Scientific American
scientificamerican.com/article

Masks are, if correctly and consistently worn, effective in reducing transmission of respiratory diseases and show a dose-response effect. - Recent research study
journals.asm.org/doi/10.1128/c

'Academics researching online misinformation in the US are learning a hard lesson: Academic freedom cannot be taken for granted. They face a concerted effort—including by members of Congress—to undermine or silence their work documenting false and misleading internet content. The claim is that online misinformation researchers are trying to silence conservative voices. The evidence suggests just the opposite.'
science.org/doi/10.1126/scienc

@cyrilpedia

Thanks. Ft has a paywall so people can use clinicaltrials.gov to directly review tests of cellular interventions for Autoimmune conditions with this simple search query:

BTW I'm finding the new disclaimer a bit weird given that to take part in any study requires a consent process that will clearly spell out the risks and uncertainties.

clinicaltrials.gov/search?cond

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