Thiago Carvalho @cyrilpedia@qoto.org

The intracellular Fc receptor strikes again:
"Mechanistic studies revealed that TTCM2-ms cleared intracellular, synaptic, and seed-competent tau aggregates through tripartite motif-containing 21 (TRIM21), an intracellular antibody receptor and E3 ubiquitin ligase known to facilitate proteasomal degradation of cytosolic antibody-bound proteins. TRIM21 was found to be essential for TTCM2-ms–mediated clearance of tau pathology."
https://www.science.org/doi/full/10.1126/scitranslmed.adj5958

'Over the four-week tournament, football fans from England to Georgia discovered often to their surprise just how unreliable the trains were. “If it wasn’t already clear, the [experience during the] Euros showed just what a problem Deutsche Bahn has with reliability and punctuality”

https://www.theguardian.com/world/article/2024/jul/15/germany-close-key-rail-corridor-overhaul-train-network-deutsche-bahn

'A situação em Gaza é inimaginável e a inação da União Europeia compromete a sua credibilidade como agente de paz. Para construir a paz na Europa, a União Europeia precisa de um discurso sério e coerente sobre a paz, para ser levada a sério pelo mundo.'

https://www.tsf.pt/61549809/catarina-martins-a-tsf-uniao-europeia-tem-dois-pesos-e-duas-medidas-nos-varios-conflitos/

'In this article, we discuss the potential role of N-of-1 trials in cancer drug development in the era of personalized cancer medicine. We also elaborate on a suggested modified design for N-of-1 trials able to overcome limitations and make this concept more applicable to clinical oncology.'

https://aacrjournals.org/cancerdiscovery/article/13/6/1301/726949/N-of-1-Trials-in-Cancer-Drug-Development

'We pair this with a discussion about who has the power to make these changes, from funders to administrators to teachers and people outside of academia. The aim is to teach students that there are people behind the decisions and priorities of academia and research, and thus these issues can be addressed by getting the right people involved.'

https://onlinelibrary.wiley.com/doi/10.1002/jcp.31352?utm_medium=email&utm_source=substack

'This is obvious gaming of the system, in order to benefit people who are being evaluated by systems that are themselves set up like some sort of game. It reminds me of the old Soviet joke, "As long as they pretend to pay me, I'll pretend to work". But surely there are better ways to spend ones time and effort - and surely the scientific literature is not served by having yet more garbage dumped into it. I know, this is all happening down in the Lower Depths of the mass of published papers, but floods of sewage need to be addressed in general even if they're not washing over your driveway.'

https://www.science.org/content/blog-post/more-citation-weirdness