Thiago Carvalho @cyrilpedia@qoto.org

Comorbidities raise the risk of death of any disease, but it's MUCH worse with #COVID19. A data study looked at mortality for various pathologies in relationship to the number of comorbidities.

Two comorbidities increased the risk of death 4.8x for cardiovascular disease, 5.0x for cancer, and 9.3x for COVID.

But six comorbidities increased the risk of death 12.1x for cardiovascular disease, 12.5x for cancer, and 136.7x in those with COVID.

https://link.springer.com/article/10.1186/s43162-024-00348-y

#UK #Uspoli #Uspol #Cdnpoli #ShitTalkers #Liars #Haters #Musk #RightWingExtremist #Riots #FarRight

Hate speech has consequences.

Man who

used social media to stoke racial hatred

encouraged torching hotels for asylum seekers in Britain

gets 3 years in prison

https://www.ctvnews.ca/world/man-who-encouraged-torching-hotels-for-asylum-seekers-in-the-u-k-gets-3-years-in-prison-1.6995164#:~:text=The%20term%20handed%20down%20to,the%20latest%20rioting%20in%20Britain.

A paragraph from the brilliant work of the "chess genius" Garry Kasparov summarises our issues with "artificial intelligence"...
#machinelearning #AI #artificialintelligence #deeplearning #ML @cyrilpedia

@flexghost

Fascist movements co-opt media outlets to shift blame away from themselves & the consequences of their greed.

Hitler's American Friends & Hitler's Aristocrats paid for favorable propaganda.

It worked right until a world war that killed 90 million people.

That's the future the rich are buying, a charred cinder for a planet, either in war or climate collapse.

The greed of the rich caused the 1929 Crash, Great Depression & WW2
https://www.worldatlas.com/world-wars/how-the-stock-market-crash-of-1929-led-to-world-war-ii.html

https://www.washingtonpost.com/books/2023/10/17/rachel-maddow-prequel-fascism-book-review/

1/2

Pop quiz! Just for fun, not for a letter grade. We just started producing weekly science quizzes as part of a new games section at Scientific American & we're having a blast with them https://www.scientificamerican.com/game/science-quiz-2024-08-09/ and here's our games landing page: https://www.scientificamerican.com/games/

"This review discusses state-of-the-art techniques for the simultaneous profiling of multiple chromatin features in low-input samples and single cells, focusing on histone PTMs, DNA-binding, and chromatin proteins."

https://www.embopress.org/doi/full/10.1038/s44319-024-00199-2

'Times Square’s decline can be dated to the Depression, which introduced burlesque, flea circuses, and dime-a-dance halls, but it wasn’t until the 1970s that the bottom fell out. The grand Broadway palaces partitioned themselves into grindhouse theaters; Forty-Second Street became “the Deuce”; Strip-Tease gave way to Peep Show; Peep Show gave way to Live Sex. Still, it is possible to detect, in Friedman’s chronicles, beneath the squalor and disgust, contravening subtones of glee, ribaldry, even elation.'

https://www.criterion.com/current/posts/8549-how-the-movies-captured-times-square-s-grimy-golden-age

Surprise du jour

"Google and Meta made a secret deal to target advertisements for Instagram to teenagers on YouTube, skirting the search company’s own rules for how minors are treated online."

https://www.ft.com/content/b3bb80f4-4e01-4ce6-8358-f4f8638790f8

NOD news:
"Utilizing a Treg-centric screen, we show that intraislet Tregs have a uniquely dysfunctional phenotype, hallmarked by an almost complete lack of neuropilin-1 (Nrp1), a cell surface receptor required to maintain Treg stability."
#Immunology
https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2300216/267054/Regulatory-T-Cell-Insufficiency-in-Autoimmune?redirectedFrom=fulltext

'After Covid-19 vaccines transitioned to the commercial market last fall, the Centers for Disease Control and Prevention stepped in to ensure that adults without insurance, or those whose insurance plans did not fully cover the vaccine, could receive shots for free. The agency’s Bridge Access Program provided roughly 1.5 million shots, said Dr. Georgina Peacock, the director of the immunization services division at the C.D.C. Nationwide, about 27 million adults do not have health insurance.

But the program ends this month, making it even harder for health centers to provide shots for free. The C.D.C. announced in May that funding for the program, which clinics expected to last through December, would actually run out by the end of August. A spokesman from the C.D.C. said the agency is discussing strategies to increase vaccine access for people without insurance.'
https://www.nytimes.com/2024/08/06/well/cdc-covid-vaccines-free-program.html

Tools
"We developed a highly sensitive assay for detecting protein–protein interaction using chimeric receptors comprising two molecules of interest in the extracellular domain and interferon alpha and beta receptor subunit 1 or 2 (IFNAR1/2) in the intracellular domain."
#Immunology
https://www.pnas.org/doi/10.1073/pnas.2318190121

'The idea of cancer as predominantly a disease of old age is beginning to creak. An analysis last year showed that, in the G20 group of industrialised nations, rates of several cancers are rising faster among the young than among the old.'

https://www.ft.com/content/491d7760-c329-4f57-9509-0da36bc9e7de

'They also found that children with MIS-C had an unusual immune response to the coronavirus: They made antibodies to a part of the viral nucleoprotein that the other children who had severe Covid did not.
Then came their “aha moment,” Dr. DeRisi said: The part of the viral nucleoprotein that the children with MIS-C react to is remarkably similar to a section of SNX8.'
#Covid #Covid19 #MISC
https://www.nytimes.com/2024/08/07/health/misc-autoimmune-children.html

'Algranati, Oren et al. therefore set out to test whether combining an HDACi known as Vorinostat with a drug that blocks MYC activity (Sulfopin) can act as an effective treatment for this cancer (Diffuse midline gliomas).'

https://elifesciences.org/digests/96257/stronger-together?utm_source=linkedin&utm_medium=social&utm_campaign=organic

Adam Tooze (via The Browser)
"Imagining a really bad future for American leadership in the world economy? Want to know what hegemonic malfunction really looks like? Check out the politics of Washington DC, in the immediate aftermath of World War I! The combination of domestic and international policies adopted at that point was uniquely counterproductive and reflected a crisis on the US home front that is underrated in its severity."
https://adamtooze.substack.com/p/chartbook-304-hegemonic-malfunction?ref=thebrowser.com

When Climate Funds Pay for Highway Expansion
https://www.bloomberg.com/news/features/2024-08-07/can-adding-highway-lanes-bring-transportation-emissions-down?utm_source=flipboard&utm_medium=activitypub

Posted into Transportation @transportation-citylab