Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'In 1984, Dr. Warren and his collaborator, the gastroenterologist Barry Marshall, published a paper in the British medical journal The Lancet describing their finding that the spiral-shaped bacterium now commonly called H. pylori festered in the stomachs of patients with ulcers and gastritis. Dr. Warren had first noticed the bacterium on a gastric biopsy sample in 1979.'
https://www.nytimes.com/2024/08/09/health/j-robin-warren-dead.html
'The degree of underfunding or overfunding is different for the groups of conditions, too. On average, female-dominant diseases that are underfunded are more severely so. For chronic fatigue syndrome, also known as myalgic encephalomyelitis (ME/CFS), for example, the ratio of burden to funding is 0.04. For HIV/AIDS, the ratio is 15.6.'
https://www.nature.com/immersive/d41586-023-01475-2/index.html
Thiago Carvalho
boosted
BBC News - https://www.bbc.co.uk/news/resources/idt-e885e189-aee4-4250-bbfc-c7f3c52f4d48
‘My shop was looted by rioters, then saved by strangers’ - BBC News
Thiago Carvalho
boosted
Republicans are smearing the free school breakfast & lunch program Gov Tim Walz signed into law as “socialism.”
Meanwhile, Trump’s Project 2025 calls for slashing existing school lunch programs on p. 302 of the playbook.
Why does the GOP want to see children go hungry?
'Judicial hostility to labor is hardly a new phenomenon. As Jackson noted in her partial dissent, “To put it bluntly, courts exercising their equitable discretion amidst labor disputes today do so against the backdrop of an ignominious history of abuse.”
'The head of the Africa Centres for Disease Control and Prevention (CDC) has said the agency is likely to declare a continental public health emergency over the growing mpox outbreak.
The Africa CDC’s director general, Dr Jean Kaseya, said on Thursday that because of the increase in mpox cases and its continued spread across borders, he had resolved to start “active engagement” with African Union member states to prevent the outbreak from becoming “another pandemic”.'
https://www.theguardian.com/world/article/2024/aug/08/mpox-outbreak-puts-africa-on-brink-of-official-public-health-emergency?utm_source=substack&utm_medium=email
Thiago Carvalho
boosted
V Guardian opinion:
There can be no excuses. The UK riots were violent racism fomented by populism
written by David Olusoga
https://www.theguardian.com/commentisfree/article/2024/aug/10/there-can-be-no-excuses-the-uk-riots-were-violent-racism-fomented-by-populism?CMP=Share_AndroidApp_Other
#UKRiots
“Alarm bells went off when Šimkovičová took over the culture portfolio last autumn,” said Albin Sybera, a fellow of the central European policy thinktank Visegrad Insight. “What we saw again last week is that those fears were not unfounded. We are seeing a spreading of radical rightwing positions into Slovakia’s mainstream discourse.”
'Anakinra inhibited NFκB activation in CLL cells in part by lowering oxidative stress and led to transient tumor regression in patients. However, IFN signaling became up-regulated and was associated with loss of the initial clinical response.'
'Lá fora, Lisboa é referência para absolutamente tudo. Gostam da nossa cultura, da nossa comida, do nosso estilo de vida. Elogiam os preços ‘baratos’, a beleza das nossas cidades e a hospitalidade das nossas pessoas. Mas a realidade vivida na capital é conhecida por aqueles que aqui vivem, viver em Lisboa tornou-se um pesadelo para os Lisboetas e um paraíso para os tourists e os expats.'
Thiago Carvalho
boosted
'The legacy of colonialism in scientific research includes an intellectual property system that favors Global North countries and the big corporations they support. This unfairness shows up in who gets access to the fruits of science and raises the question of who science is designed to serve or save.'
Thiago Carvalho
boosted
'There’s no way to put a price on the pain and suffering prevented by childhood vaccines. But as it turns out, you can pinpoint the savings to the country.
For nearly three decades, childhood vaccines — including those that target measles, tetanus and diphtheria — have saved the United States $540 billion in health care costs, according to a new report from the Centers for Disease Control and Prevention.'
https://www.nytimes.com/2024/08/09/health/childhood-vaccines.html
“On average, everyone’s weight rapidly returned,” Dr. Cummings said. And, he said, other medical conditions, like elevated blood sugar and lipid levels, return to their previous levels after improving.'
https://www.nytimes.com/2024/08/09/health/ozempic-weight-loss-drugs.html
Thiago Carvalho
boosted
Novel Insights into Post-Myocardial Infarction Cardiac Remodeling through Algorithmic Detection of Cell-Type Composition Shifts https://www.biorxiv.org/content/10.1101/2024.08.09.607400v1?med=mas
Thiago Carvalho
boosted
Discovering nuclear localization signal universe through a novel deep learning model with interpretable attention units https://www.biorxiv.org/content/10.1101/2024.08.10.606103v1?med=mas
'The legacy of colonialism in scientific research includes an intellectual property system that favors Global North countries and the big corporations they support. This unfairness shows up in who gets access to the fruits of science and raises the question of who science is designed to serve or save.'
Thiago Carvalho
boosted
'Helsinki recorded no deaths for the first time since records began in 1960, down from an average of 20-30 a year in the 1990s. In Oslo, there were also no pedestrian or cyclist deaths in the city, which has a population of 680,000, and no children under 16 died in traffic crashes in the entire country.'
https://www.theguardian.com/world/2020/mar/16/how-helsinki-and-oslo-cut-pedestrian-deaths-to-zero?s=09
Thiago Carvalho
boosted
'Daiichi is buying into the development of MK-6070, a trispecific T-cell engager that Merck acquired when it bought Harpoon for $650 million earlier this year. MK-6070, formerly known as HPN328, is designed to bind CD3 on T cells and DLL3 on tumor cells. The third domain binds albumin to extend the half-life.'
#Immunology #Immunotherapy
Thiago Carvalho
boosted
"Imagine um país no qual autores, escritores e ilustradores são assediados por bandos organizados que os ameaçam nas redes e intimidam verbal e fisicamente de cada vez que estes apresentam os seus livros. Não precisa de imaginar muito longe: esse país é Portugal. Agora imagine o que acontece a seguir: nada."
https://expresso.pt/opiniao/2024-08-08-os-liberautoritarios-ef8a5676
'Ben-Gvir, o supremacista de extrema-direita que é ministro da Segurança Nacional, incendiou as redes dizendo "tirem as mãos dos nossos heróis". Smotrich, ministro das Finanças, idem. Uma turba de israelitas disparou para Sde Teiman, trepando vedações, empurrando guardas.'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
