Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
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@genomeresearch is now on Mastodon. Follow us here for the lasted genomics publications and recent news.
#Introduction. Genome Research (www.genome.org) is an international, continuously published, peer-reviewed journal that focuses on research that provides novel insights into the #genome biology of all organisms.
Thiago Carvalho
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RT @OncoUNILCHUV
𝑵𝑬𝑾 𝑺𝑻𝑼𝑫𝒀 by @GfellerD lab develops MHC Motif Atlas to visualize and compare binding motifs for MHC-I and MHC-II alleles.
@NAR_Open📄http://bit.ly/3AVjIFF
#CancerResearch @unil @CHUVLausanne @Ludwig_Cancer.
With the support of @Krebs_Forschung foundation.
Thiago Carvalho
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Wondering how accurate #AlphaFold models are?
We compared #AlphaFold predictions with experimental data. Many parts are great, but even high-confidence #AlphaFold predictions have distortions, domain movements, backbone errors, and side chain errors.
Thiago Carvalho
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Holy moly. This is gonna be a time sink of massive dimensions. Much of the Boston Public Library's vinyl collection digitized on archive.org
Lots of stuff you know and lots more you don't.
"MFN2 Q400 is the first known natural mitophagy- and shape change-defective MFN2 mutant. Its unique profile of dysfunction evokes mitophagic cardiomyopathy, suggesting a mechanism for its enrichment in clinical #cardiomyopathy."
https://www.biorxiv.org/content/10.1101/2022.11.22.517462v1?med=mas
Thiago Carvalho
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The Linkage-Disequilibrium and Recombinational Landscape in Daphnia pulex https://buff.ly/3tJzD5C #science #evolution #biology #daphnia #recombination
Thiago Carvalho
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Recognizing #preprints with peer reviews - funders & institution session with @ThomasGuillem@twitter.com (@PeerCommunityIn@twitter.com), Fiona Watt (@EMBO@twitter.com), and @JohanRooryck@twitter.com (@cOAlitionS_OA@twitter.com).
Register to watch the livestream on Dec.1-2:
https://buff.ly/3G0fpfz
#RecognizingPreprintReview
Thiago Carvalho
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Tomorrow I will be striking in pursuit of fairer pensions and to protest inequality, excessive workloads and casualisation for my UCU colleagues
Also tomorrow, my children’s school teachers will be striking in pursuit of a fair and just pay settlement
So, plans are afoot for a day of wee teach-outs
- Home Economics: bake cookies for the picket line
- Politics tutorial: what’s a picket line?
Music & history lessons: protest songs through the decades. Suggestions welcome.
Thiago Carvalho
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Save the date! We are delighted and honoured to host the next #Behaviour2023 conference, 14-20 August 2023!
Learn more about the conference in www.behaviour2023.com
See you all in Bielefeld!
Thiago Carvalho
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This Months #editorschoice
Guppies are a classic example of #parallelevolution but are they really so parallel? An analysis of published #guppy papers by @alexisheckley @AllegraPearce4 @photopidge @ecoevoevoeco @KristaOke
shows low extent of parallelism
http://ow.ly/s8S450LLUG9
#evolution #guppy #guppies #societyjournal
Thiago Carvalho
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Genome Research @genomeresearch is now also here!
Thiago Carvalho
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The most recent approved gene therapy, as @STAT reports, will cost $3.5m per patient.
Editas just abandoned a gene editing program because it has <300 patients in the US.
= the challenge of affordability and health justice for CRISPR cures has never been this urgent.
https://www.statnews.com/2022/11/22/fda-approves-a-gene-therapy-for-the-inherited-bleeding-disorder-hemophilia-b/
Thiago Carvalho
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I’m a clinician scientist and ICU consultant based in Cambridge, UK. I study the immune effects of critical illness, particularly why neutrophils fail and how this leads to nosocomial infections. Through this I’ve collided with a number of research areas, including diagnostics for pneumonia, transcriptional responses to pathogens and air scrubbing- collecting eclectic interests along the way.
Active in ESICM, currently chairing the INF section.
Thiago Carvalho
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"The mere existence of such a cell should be one of the great astonishments of the earth."
"People ought to be walking around all day, all through their waking hours calling to each other in endless wonderment, talking of nothing except that cell.”
by Lewis Thomas, from "The Medusa and the Snail"
Watch a Salamander emerge From a Single Cell https://www.youtube.com/watch?v=SEejivHRIbE
'We have developed OpenFold, a complete open-source reimplementation of AlphaFold2 that includes training code and data. By training OpenFold from scratch and matching the accuracy of AlphaFold2, we have demonstrated the reproducibility of the AlphaFold2 model for protein structure prediction. Furthermore, the OpenFold implementation introduces technical advances over AlphaFold2, including markedly faster prediction speed.'
https://www.biorxiv.org/content/10.1101/2022.11.20.517210v1?med=mas
Thiago Carvalho
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*PRO NERD TIP*
Today I learned about "The Wikipedia Library Card". If you've been a WP editor for >6 months, have made >500 edits, at least 10 edits in the last month, and are not blocked for being a cretin, you can access a *ton* of paywalled content for free.
ScienceDirect, AAAS, The BMJ, both APAs, EBSCO, Springer, Nature, Wiley, and many more.
https://wikipedialibrary.wmflabs.org/about/
All those hours in 2005 spent editing sci-fi book articles finally paying off!
Thiago Carvalho
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"The advent of the gene-editing technology CRISPR–Cas9 in the 2010s provided a catalyst for the field, making it easier to modify not only the gene involved in α-Gal production, but a host of others that might help human bodies to tolerate pig organs."
RT @Nature@twitter.com
Will pigs solve the organ crisis? The future of animal-to-human transplants https://go.nature.com/3EWxMRu
Richard Lenski (at his blog) on S.J Gould & the #LTEE
"Of course, Gould’s experiment is impossible at a paleo-planetary scale. But at a more modest scale, one of the main goals of the LTEE is to study the repeatability of evolution. And so, I often quote from Wonderful Life when I’m giving talks about the experiment. Thus, it’s only natural that someone might wonder if Gould’s book had inspired me to start the LTEE."
#Evolution
https://telliamedrevisited.wordpress.com/2022/11/22/its-a-wonderful-life/
Thiago Carvalho
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#introduction
I’m a conservation biologist focusing on #cetaceans. I'm presently using molecular, ecological, and demographic approaches to understand the interconnectedness of bottlenose dolphins in the Iberian Peninsula region; with a particular interest in the declining resident population of Sado estuary, 🇵🇹 !!
Before, I studied cetaceans (mostly humpback whales) in 🇸🇹 (west Africa).
Other interests around here: #popgen,#POPs, #marineconservation; #MPAs; #SciComm
'At the time, Argentina’s regime, the bloodiest in modern South American history, was rounding up thousands of real and presumed leftists and putting them in torture camps or killing them outright in what came to called the “dirty war.” The dictatorship lasted seven years, during which at least 8,960 people disappeared, according to official estimates. Some human rights groups put the figure at 30,000.'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
