Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Japanese dengue vaccine becomes second approved by EU
Japanese pharmaceutical company Takeda said the European Union had given the green light to its dengue fever vaccine, making it the second jab preventing the disease to be approved by the bloc.
https://medicalxpress.com/news/2022-12-japanese-dengue-vaccine-eu.html
Thiago Carvalho
boosted
‘In the early 2010s, new social media sites like Facebook and Twitter were tools for emerging protest movements; now, they increasingly act as a substitute for them.’
@michael_chessum@twitter.com on the solution to digitally-enabled inaction:
"Phenotypic drug discovery has seen a general resurgence in the past 20 years, with several first-in-class drugs with no known molecular target recently approved by the US FDA, albeit largely for use outside of psychiatry [1]. We believe that phenotypic drug discovery has the potential to uncover previously unknown disease-relevant cellular signaling pathways or neural circuits and inform a deeper understanding of the pathophysiology of central nervous system diseases."
#DrugDiscovery #Neuroscience #PLOSBiology
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001904
Thiago Carvalho
boosted
RT @sangerinstitute@twitter.com
The developing human lung has been mapped in unprecedented detail, identifying 144 cell types in the early stages of life
Acting as a guidebook to healthy lung development, this can be used to investigate how #lungdiseases originate
Read more 👇🏻
https://bit.ly/3P8C9MQ
🐦🔗: https://twitter.com/sangerinstitute/status/1600887574729732096
Thiago Carvalho
boosted
New structural insights into DNMT1 function! This protein remains full of surprises. From @KyoheiArita@twitter.com's group, with help from our neighbors @Kosuke_Y_1989@twitter.com and @DefossezPierre@twitter.com. Congrats all! https://www.nature.com/articles/s41467-022-34779-4
Thiago Carvalho
boosted
#Advent Day9: Now we jump to the subgenus #Drosophila (confusing, I know) and meet the root of the taxonomic mess: D. funebris. This species cannot be renamed without an act of god (or the ICZN https://doi.org/10.21805/bzn.v67i1.a14 ), so we must either rename melanogaster or live with paraphyly https://academic.oup.com/genetics/article/185/2/703/6096929 . When not upsetting taxonomists, Dfun is a human commensal that likes farmyard manure and nearly made it as a lab model https://doi.org/10.1002/jez.1400510206 , but hasn’t done much in the lab since the 1980s
Thiago Carvalho
boosted
RT @sj_marzi@twitter.com
📢 Come and join our team! My lab is recruiting a postdoc to work on cell type specific epigenetic regulation in Alzheimer's disease. Apply by 4 Jan.
Email for queries and apply here:
👉 https://tinyurl.com/5c8hy52v
Please RT.
Thiago Carvalho
boosted
Having read this book by @drcpennington already, I can really not recommend it enough. From all texts on open science and the replication crisis, this is the one I would give to my students. A comprehensive, *optimistic*, and inspirational overview of the topic!
Thiago Carvalho
boosted
Exciting new paper on dopamine (DA).
Bellman: created an equation describing how to make choices to maximize value. But it required infinite memory.
Sutton & Barto: Came up with a new way, by calculating the difference between what happened & what you expect. This 'reward prediction error' was mapped to DA in the brain.
New paper: not quite. Instead, the brain computes whether a stimulus precedes reward beyond that expected by chance (causality).
Thiago Carvalho
boosted
#introduction
Hello everyone!
I’m an associate prof at Virginia Tech studying viral diversity. Lately my group has been focusing on giant viruses, but we are also interested in other protist viruses, and the role of viral endogenization in host genome evolution.
#GiantViruses #ViralDiversity #TreeOfLife #Protists #Microbiology #Bioinformatics #Evolution #Virology #Genomics
Recently we have been examining the strange and complex genes encoded in giant virus genomes!
https://doi.org/10.1093/femsre/fuad053
Thiago Carvalho
boosted
The @nytimes in no small part helped to normalize the pandemic--remember #Omicron is milder--while making cases against mitigation as doing more harm than good (causing everything from teen suicides to car crashes).
Now this piece by David Wallace-Wells just says the truth out loud. We're see massive death still and it's not just a "pandemic of the unvaccinated." It's our grandparents who are dying. We are sacrificing our elders for our thirst for normal.
https://www.nytimes.com/2022/12/07/opinion/environment/covid-19-pandemic-elderly-deaths.html
Thiago Carvalho
boosted
"Although the process of human-to-human transmission is multifactorial, viral load substantially contributed to human-to-human transmission, with higher viral load posing a greater risk for onward transmission"
https://www.nature.com/articles/s41579-022-00822-w
Thiago Carvalho
boosted
RT @bewersdorflab
Our latest work on #bioRxiv answers a simple question: can you see cellular substructures and ultrastructure without fluorescence, or even a 🔬? - Yes, you can! With #UnclearingMicroscopy! @OnsMSaad1 @mshribak @YaleCellBio
https://www.biorxiv.org/content/10.1101/2022.11.29.518361v1
"Here we used targeted #CRISPR screening to identify secreted protein effectors required for parasite survival in IFNγ-activated human cells. Independent screens were carried out using two Toxoplasma strains which differ in virulence in mice, leading to the identification of effectors required for survival in IFNγ-activated human cells."
'Afastou-se, entretanto, muito da fome-zero, mas também de imensos outros Objetivos de Desenvolvimento Sustentável, que regrediram várias décadas. Mas o da fome-zero regrediu consideravelmente. Neste momento, temos oito mil milhões de pessoas no mundo e 10%, 800 milhões, estão em insegurança alimentar, em menor ou maior grau. Desses 800 milhões, 50 milhões estão à beira da fome e em risco de morrerem nas próximas semanas ou meses.'
'Before Covid, few people had heard of respiratory syncytial virus (RSV). Increasingly, though, this common cause of pneumonia and bronchiolitis (airway inflammation) is filling up hospital beds across Europe and the Americas. Combined with rising admissions for other respiratory infections, including influenza and Covid, it is pushing some healthcare systems close to the brink of collapse.'
'The situation echoes the dearth of official information during the disastrous initial outbreak in Wuhan nearly three years ago. Local officials and analysts warned that the reduced testing, as well as gaps in reporting of both cases and deaths, would make it harder to assess the risk to the world’s second-biggest economy.'
#COVID #Covid19 #PublicHealth
https://www.ft.com/content/abefb06e-a5a7-432b-85bf-b3250b53836f
Thiago Carvalho
boosted
RNA-binding protein #Rbm14 condensation together with #m6A-modified maternal mRNAs and #RNA #deadenylase Parn controls their #translational competence and decay for vertebrate #blastula #development
New article by Yue Xiao, Jiehui Chen et al:
https://www.embopress.org/doi/10.15252/embj.2022111364
Thiago Carvalho
boosted
So I won't cross-post much, but for my very first clinical Toot, I wanted to share images that those who follow me on #IDTwitter know well. Below is the current COVID monoclonal antibody situation and susceptibility to current variants. Where I am in Massachusetts, we are not giving any more bebtelovimab #COVID19 #IDMastodon
Thiago Carvalho
boosted
Time for the #firstpost on this account!
Latest on @eLife Sparks of Change: a very thoughtful piece about the challenges of balancing community outreach and a science PhD without losing yourself.
Lots to think about here, absolutely worth a read👇
https://elifesciences.org/articles/85166?utm_source=twitter&utm_medium=social&utm_campaign=organic
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
