Thiago Carvalho @cyrilpedia@qoto.org

I never really believed this of a multichannel.

'In 1976, he invited me to join him at the Salk Institute for Biological Studies in La Jolla, California, where he was a visitor. He introduced me to the laboratory and its inhabitants with a beguiling sense of analytical distance. Reverently picking up a pipette, he said: “This, they believe, measures the amount of a liquid.”'
#BrunoLatour

https://www.nature.com/articles/d41586-022-03796-0?utm_source=twitter&utm_medium=social&utm_content=organic&utm_campaign=CONR_JRNLS_AWA1_GL_SCON_SMEDA_NATUREPORTFOLIO

'What types of responses can occur transgenerationally? Can the brain coordinate these responses?'

Throwback to the Fall of 2021, the second #EMBOPodcast with @Odedrechavi "Physiologically Irreverent"

#Celegans #Epigenetics #Neuroscience #Nematodes #RNA

https://www.embo.org/podcasts/physiologically-irreverent/

'La bête du Gévaudan a tué au moins 78 paysans sur un territoire délimité, dans le Gévaudan, au XVIIIe siècle. L'affaire a durablement terni l’image du loup, faisant de celui-ci une créature sanguinaire et l’ennemi public numéro 1 pour les éleveurs, comme le relate l'historien Bernard Soulier : "Les sources dont disposent les historiens évoquent une bête très grosse, raie noire sur le dos, tâche blanche au poitrail. Les témoins n’ont pas réussi à l’identifier formellement. Ils ont toujours dit : “Cette bête ressemble un petit peu à un loup mais est différente du loup par plusieurs points.”

https://www.radiofrance.fr/franceculture/la-bete-du-gevaudan-etait-elle-vraiment-un-loup-6496208

'The mechanism underlying these findings was examined in experiments in mice that showed that germinal centers (GCs) formed in the presence of the same antibodies were dominated by low-affinity B cells. Our results indicate that pre-existing high-affinity antibodies bias GC and memory B cell selection by two distinct mechanisms: (1) by lowering the activation threshold for B cells thereby permitting abundant lower-affinity clones to participate in the immune response, and (2) through direct masking of their cognate epitopes. This may in part explain the shifting target profile of memory antibodies elicited by booster vaccinations'

#Immunology #Bcells #GerminalCenter #Covid19

https://www.nature.com/articles/s41586-022-05609-w

"Taken together, beyond revealing the central role of cristae architecture to prevent mtDNA release and inflammation, our results mechanistically link mitochondrial cristae disorganization and inflammation, two emerging hallmarks of aging and aging-related degenerative diseases."

#mitochondria #inflammation #InnateImmunity #Immunology

He et al @CellReports

https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01657-6

The NYT list of best podcasts of 2022 includes a life sciences one that I was not aware of:

"‘Unexplainable’

Where did the moon come from? What sounds did dinosaurs make? Does anyone know how smell receptors actually work? In this weekly science series, Noam Hassenfeld, Brian Resnick, Meradith Hoddinott and the explainers at Vox devote their attention to the basic facts of life we don’t understand, which, as anyone who’s spent time with a five-year-old knows, is a longer list than you might think. Always artfully scored and produced — especially in mini-series about human senses and the solar system — “Unexplainable” never feels like homework. At a time when many people see profit in false or oversimplified claims about reality, it’s refreshing to be reminded of what the search for truth really sounds like. (Listen to “Unexplainable” from the Vox Media Podcast Network.)"

https://www.nytimes.com/2022/12/08/arts/best-podcasts-2022.html

'As the story goes, a long time ago in Bavaria, beer underwent a transformation. Dark ale turned into a paler, gold-hued drink, and the beverage grew much more common around the time when a ducal edict restricted brewing to the winter months. The lager, as the new beer was called, had begun its journey to world domination.

Centuries on, geneticists have found that the yeast responsible for fermenting lagers is a hybrid of the traditional brewer’s yeast and another, cold-hardy yeast, Saccharomyces eubayanus. The lager yeast appears to be the result of a chance mating in a chilly brewery, where low temperatures allowed the hybrid to thrive.'

https://www.nytimes.com/2022/12/07/science/beer-yeast-lager.html

"Mark Filip, a former federal judge and Department of Justice official who now defends white-collar clients, will lead the investigation into Stanford president Marc Tessier-Lavigne, the university said in a statement on Wednesday. Stanford had previously tasked an internal committee made up of its board of trustees with investigating allegations of altered images in papers co-authored by Tessier-Lavigne. The special committee initially included an investor in a startup co-founded by the university president, who has since stepped aside for the investigation."

https://www.statnews.com/2022/12/08/amid-criticism-stanford-turns-over-review-of-its-president-to-outside-investigator/