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An Interlude in Microbiology

by Elio
If before 1950 you had asked "are bacteria cells?" the chances are that you would be told "it depends…" In other words, no one knew for sure. It took Joshua Lederberg, who, upon discovering mating in E. coli, proposed that bacteria were indeed cells...

Read more → schaechter.asmblog.org/schaech

#microbiology #cell

Corvos imaginários, papagaios estocásticos e outros animais que falam, de Manuel Arriaga, pretende apresentar algumas ideias em torno do tema ChatGPT, indo um pouco além das discussões que geralmente se encontram nos media:

almanaquemag.com/corvos-imagin

📸 Alessio Ferretti
#almanaque #almanaquemag #manuelarriaga #chatgpt

SSB is launching a new mentorship program to cultivate relationships among members of the systematics and phylogenetics community.

We're now recruiting a pool of mentees and mentors for our first group of participants!

Learn more: systbio.org/mentoring-program.

Enroll here: forms.gle/mc2gPDwaTGYvcR1k7

'A key feature of the accelerated approval system is that manufacturers are required to conduct post-approval studies to demonstrate the drug’s therapeutic value. Among 93 cancer drug indications granted accelerated approval between 1992 and 2017, confirmatory trials reported an overall survival improvement in only 20% of them.'

cell.com/cell/fulltext/S0092-8

'Discounts or rebates (a subcategory of so-called “managed entry agreements”) on drug prices are negotiated between governments and manufacturers, and a growing number are confidential.7 Confidential rebates are especially applied to cancer drugs.8 In consequence, countries using the external reference pricing system overestimate actual prices, triggering an upward spiral of drug prices.'

cell.com/cell/fulltext/S0092-8

'After a public dispute with NPR, which Twitter falsely labeled state-affiliated media, the platform last week removed all labels that had identified state-owned media, including those controlled by authoritarian states like Russia, China and Iran.'

nytimes.com/2023/04/26/technol

RT @NatMetabolism
Online now! Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction dlvr.it/Sn6VKR

New preprint from Geert Kops and co. on the role of CENP-E in building the kinetochore corona expansion. I've always been intrigued by the farnesyl (lipid) modification on CENP-E, identified years ago by Stephen Taylor's lab. This new preprint suggests that this modification and CENP-E have a structural (non-motor) role in stabilising corona expansion.

biorxiv.org/content/10.1101/20

#CellBiology #mitosis #motors

"Transplantation of hNSCs has been shown to increase the number of CD4+CD25+Foxp3+ T regulatory cells (Tregs) in the spinal cords of murine models of MS, which is correlated with a strong localized remyelination response. However, the mechanisms by which hNSC transplantation leads to an increase in Tregs in the CNS remains unclear."

journals.aai.org/jimmunol/arti

'In briefing documents published ahead an advisory committee meeting, FDA staffers argue that in metastatic castration-resistant prostate cancer (mCRPC), Lynparza has only showed a favorable benefit-risk profile in patients with BRCA mutations.'

fiercepharma.com/pharma/fda-ar

@cyrilpedia Their observations show no change in the percentage of total #tumor associated #macrophages (TAMs) in the tumor tissue but a markedly increased percentage of NOS2+TAMs with no significant changes in arginase I expression...raising the question, which cell type would be the corresponding human counterpart? Macrophage or #monocyte ?

'Under pressure from their government, Chinese scientists have withheld data, withdrawn genetic sequences from public databases and altered crucial details in journal submissions. Western journal editors enabled those efforts by agreeing to those edits or withdrawing papers for murky reasons, a review by The Times of over a dozen retracted papers found.'

nytimes.com/2023/04/23/world/e

"Getting Franklin’s story right is crucial, because she has become a role model for women going into science. She was up against not just the routine sexism of the day, but also more subtle forms embedded in science — some of which are still present today."

nature.com/articles/d41586-023

'25 de Abril sempre, diz Rui Rocha. Mas que demonstra ele saber sobre o 25 de Abril? Nada. O povo quis uma sociedade nova e confrontou as classes dominantes – banqueiros, industriais e latifundiários – pondo em causa o seu domínio, poder e propriedade. Se recuasse no tempo, nesta luta, de que lado estaria Rui Rocha? Não é difícil de adivinhar: os interesses económicos que defende e apregoa estavam no lado do fascismo e do colonialismo, nunca no do povo.'

publico.pt/2023/04/26/opiniao/

'Dr. Franklin’s early death also meant she missed out on the Nobel Prize, but the Nobel Assembly could have found other ways to acknowledge her contribution, said Nils Hansson, a historian of medicine at Heinrich Heine University Düsseldorf, in Germany. Neither Dr. Watson nor Dr. Crick mentioned her when they accepted their awards, Dr. Hansson noted, although Dr. Wilkins, who also received the prize, did.'

nytimes.com/2023/04/25/science?

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