Thiago Carvalho @cyrilpedia@qoto.org

'The review correctly identifies a multitude of factors that have led to a decline in clinical trials, including the pressures on the Medicines and Healthcare products Regulatory Agency, which has a reduced capacity and increased workload post-pandemic and post-Brexit, and other aspects of the national and local trial approvals systems, which have undermined the competitiveness of the UK clinical research environment.'

https://www.theguardian.com/commentisfree/2023/apr/26/britain-covid-research-clinical-trials-nhs-doctors?CMP=share_btn_tw

A long & winding road.

"However, our efforts to identify a chemical inhibitor of apoptosis floundered. Whatever we tested either did not work or had only a marginal effect. We wondered whether components of the pathway might have built-in redundancies. If so, the project was dead."
#Apoptosis #CellDeath

https://www.science.org/doi/10.1126/sciadv.adi2011#.ZEmbzTtPNQI.twitter

'To do so, cast your mind back to high school chemistry and Boyle’s Law. That Law was just one of Robert Boyle’s accomplishments, for he was a pillar of the Scientific Revolution. In fact, his book The Sceptical Chymist is generally considered to mark the dawn of modern chemistry, the science of how things are constituted. A friend to both Highmore and Digby, Boyle had read their work, and when his own magnum opus was published some ten years after theirs, Boyle noted a key implication of his new chemistry: to “teach us how a Chick is formed in the Egge.”'

https://thenode.biologists.com/devbiolstories-guy-fawkes-chickens-and-the-hatching-of-mechanism-in-developmental-biology/research/

Tools:

"Here we show that the yields of edited primary human lymphocytes can be increased substantially by delivering a CRISPR ribonucleoprotein mixed with an amphiphilic peptide identified through screening. We evaluated the performance of this simple delivery method by knocking out genes in T cells, B cells and natural killer cells via the delivery of Cas9 or Cas12a ribonucleoproteins or an adenine base editor."
#CRISPR #crisprcas9 #geneediting

https://www.nature.com/articles/s41551-023-01032-2

'In this study, we report that high CDK6 expression positively correlates with immunotherapy resistance in 6 of 7 single-agent immunotherapy clinical studies for melanoma patients. CDK6 depletion, but not that of CDK4, cyclin D1, or D2, in cells of the TME inhibits tumor growth.'
#immunotherapy #immunology

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00325-X

"It was only toward the middle of the twentieth century that the inhabitants of many European countries came, in general unpleasantly, to the realization that their fate could be influenced directly by intricate and abstruse books of philosophy."
Czeslaw Milosz, The Captive Mind.

#book #Books #bookshelf #bookstodon

If you're studying/generating IgG antibodies from species other than human & mouse but plan to use your abs on these organisms, this EJI might help your experimental design.

#Immunology

https://onlinelibrary.wiley.com/doi/10.1002/eji.202149766

'In this review, we focus on systems-level methods of immunometabolism that connect immune (and nonimmune) cells in tissues via metabolic communications and reveal cellular and functional heterogeneity of immunometabolic circuits.'
#Immunology #Metabolism

https://www.annualreviews.org/doi/full/10.1146/annurev-immunol-101220-031513

'I do know that I started noticing a change in my own reading habits – I'd get online and look up and 40 minutes would have gone by, and my reading time for the night would have been pissed away, and all I would have learned was that, you know, a certain celebrity had lived in her car awhile, or that a cat had dialled 911.'

https://www.theguardian.com/books/2013/apr/22/george-saunders-my-desktop-time-100?ref=thebrowser.com