Thiago Carvalho @cyrilpedia@qoto.org

@ct_bergstrom

1. There's a great explanation of the oft-cited Why Most Published Research Findings are False paper by John Ioannidis that explains why assumptions made about how scientists general hypotheses mean this is not correct.

Others have pointed this out but Carl and Jevin give a very clear explanation of why, which is important given how frequently and uncritically this work is cited in our sphere 2/3

Calling Bullshit by @ct_bergstrom is a fascinating read that brilliantly summarizes issues around data interpretation, various logical fallacies, phony graphs, and misleading statistics.

That alone makes it essential reading but two other things stood out for me that may interest sci comm/publishing types. 1/3

90% of cancers reactivate telomerase. In our new preprint, we reveal that tumors that fail to activate telomerase trigger a stronger immune response, leading to melanoma regression. Our work also sheds light on the association between telomerase gene mutations and the immune system and provide a mechanism to explore the success of immunotherapies.

🐟 #zebrafish 🧬#telomerase 💊#immunotherapy 🔬#cancerresearch https://www.biorxiv.org/content/10.1101/2023.03.24.534079v1

💥learn science from one of the best💥
---
RT @HarmitMalik
We have 2 res. tech. openings in our lab starting soon. Please RT & bring this to the attention of students interested in getting hands-on experience in the lab before heading to grad/ med school. We value curiosity, mentorship, & diversity.

1st position: https://jobrxiv.org/job/research-technician-i-malik-lab/
https://twitter.com/HarmitMalik/status/1654238564752973824

Out now! 👇Over a century ago, Elie Metchnikov proposed that #aging is caused by increasing #intestine permeability and toxic #microbiota into our bodies. In our last paper provides evidence for this idea and a potential mechanism for “inflammaging”. #IRCAN #IGC #CNRS #zebrafish 🐟 https://doi.org/10.1038/s43587-023-00401-5

'A recent American study found that an elite class of principal investigators who hold three or more concurrent NIH (National Institutes of Health) grants grew in number over the past 30 years but, even after controlling for career stage and degree, women were significantly underrepresented. And despite evidence of diminishing returns for annual grants over US$600,000, the dollars remain concentrated in the hands of a select few.'

https://www.theguardian.com/commentisfree/2023/may/04/put-a-man-on-it-the-very-short-story-of-my-medical-research-career

'For patients in a late-stage trial, the drug called donanemab slowed progression of the disease by 35 per cent compared with those who took the placebo during an 18-month treatment period. The decline in patients’ ability to perform daily tasks was 40 per cent lower for those on the drug.

However, the drug displayed severe side effects such as brain swelling and bleeding and three people on the trial died.'
#alzheimers #alzheimersdisease

https://www.ft.com/content/11a59576-e057-433a-b1f9-393159bda85c

https://www.science.org/doi/10.1126/science.adh7699

UKHSA is doing a study to try to map out immunity to #mpox. It had been assumed mpox was a one-and-done type of infection, but there have been a few reports of what looks like repeat infections, like this recent paper in Lancet. https://www.thelancet.com/action/showPdf?pii=S1473-3099%2823%2900185-8 and https://www.gov.uk/government/news/study-launched-to-find-out-more-about-mpox-immunity

'In any case, it is remarkable that senolysis of a small fraction of senescent osteocytes may account for the robust bone-protective effect, further supporting the importance of osteocytes for bone metabolism and skeletal health. Given their crucial role in orchestrating bone remodeling and their high degree of connection, these few senescent osteocytes may be sufficient to cause functional chaos through cellular miscommunication.'

https://www.jci.org/articles/view/169069

"To capture the complex interplay between the tumor antigenic landscape and anti-tumor immunity in lung cancer, we integrated genomics, transcriptomics, immunopeptidomics, spatial transcriptomics and multiplexed immunofluorescence (mIF) imaging to investigate the antigenic landscape in tumors with variable degrees of immune infiltration"
#Immunology #immunooncology

https://www.nature.com/articles/s43018-023-00548-5

Interested in a 𝘀𝗰𝗶𝗲𝗻𝘁𝗶𝗳𝗶𝗰 𝘁𝗿𝗮𝗶𝗻𝗲𝗲𝘀𝗵𝗶𝗽 in a stimulating, multicultural & multi-disciplinary research environment? 👩🏻‍🏫🧑🏽‍💻👨🏼‍💼 👩🏿‍🔬

Applications are open for our scientific traineeship!

𝙅𝙊𝙄𝙉 𝙐𝙎!
👇
https://europa.eu/!R76dyc

#EUcareers

🐦🔗: https://n.respublicae.eu/EU_ScienceHub/status/1654062548868636672

Termination of STING responses is mediated via #ESCRT- and #ubiquitin-dependent degradation to prevent unwarranted #inflammation
Katherine Balka, Dominic De Nardo et al @monashuni
https://www.embopress.org/doi/10.15252/embj.2022112712

Group Leader (m/f/x) - Fibrosis and Wound Healing @BioMed_X

The BioMed X Institute is establishing a new, fully funded research group at its new XSeed Labs incubator.

https://jobrxiv.org/job/biomed-x-institute-27778-group-leader-m-f-x-fibrosis-and-wound-healing/?feed_id=44466

#ScienceJobs #job
Ridgefield, CT #UnitedStatesUS #Grou...
https://jobrxiv.org/job/biomed-x-institute-27778-group-leader-m-f-x-fibrosis-and-wound-healing/?feed_id=44466

Mogarraz, Salamanca.

A change of scene. From the film sets near Almeria, we go to this beautiful town of Mogarraz, where the buildings have faces - literally!

Camera: Mamiya M645 1000S
Film: Ilford FP4
Developer: Ilfotec LC-29 1+19 - 7.5 minutes
.

GPS location: http://www.google.com/maps/place/40.492230,-6.053712

#photography #believeinfilm #filmphotography #analogphotography #filmisnotdead #blackandwhite #bnw #blackandwhitephotography #monochrome #spain #mogarraz