'Here, we show that yeast paralogous genes are more divergent in transcription than in translation. We explore two causal mechanisms for this predominance of transcriptional divergence: an evolutionary trade-off between the precision and economy of gene expression and a larger mutational target size for transcription.'
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010756
Martin Gardner wrote a brainteaser column for Scientific American for many years. We tested ChatGPT on his puzzles, and it turns out that if you want to solve a brainteaser, it helps to have a brain https://www.scientificamerican.com/article/you-can-probably-beat-chatgpt-at-these-math-brainteasers-heres-why/
3 #postdoc positions with the Sociable Weaver project:
1) fitness benefits of social associations, 2) role of cooperation in mate choice, 3) impact of fire on fitness and the mediating effects of sociality.
Postdoctoral Scientist – Cancer Immunosurveillance Group
Cancer Research UK Manchester Institute
come join #cancer immunonology postoc @ #CRUK Manchester Institute
See the full job description on jobRxiv: https://jobrxiv.org/job/cancer-research-uk-manchester-institute-27778-postdoctoral-scientist-cancer-immunosurveillance-group/?feed_id=46774
#Scienc...
https://jobrxiv.org/job/cancer-research-uk-manchester-institute-27778-postdoctoral-scientist-cancer-immunosurveillance-group/?feed_id=46774
'We identify a previously unsuspected extended period of genetic adaptation lasting ~30,000 y, potentially in the Arabian Peninsula area, prior to a major Neandertal genetic introgression and subsequent rapid dispersal across Eurasia as far as Australia.'
#humanevolution
"To watch Bruce Springsteen step onto a stage in New Jersey is to watch Moses walk to the edge of the Red Sea, so confident in his ability to perform a miracle, to carry his people to the Promised Land."
#HanifAbdurraqib #Book #Bookclub #Reader #Bookshelf #MusicBooks #bookstodon
"In this study, we revisit and significantly extend the initiator-titration model, proposed thirty years ago, and explain how bacteria precisely and robustly control replication initiation based on the mechanism of protein copy-number sensing."
Oh no! Look at all these Old Montréal businesses not generating any profit because of the streets being closed for cars. Utterly devastating move by the city to prevent people from accessing these businesses by having nowhere to park. How dare they doom the economy like this?
'Here, we show that yeast paralogous genes are more divergent in transcription than in translation. We explore two causal mechanisms for this predominance of transcriptional divergence: an evolutionary trade-off between the precision and economy of gene expression and a larger mutational target size for transcription.'
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010756
"Hundreds of thousands of low-income Americans have lost Medicaid coverage in recent weeks as part of a sprawling unwinding of a pandemic-era policy that prohibited states from removing people from the program."
Our experience with Elife was good but not 100%. https://elifesciences.org/reviewed-preprints/87301 IMO the reviews were fair but put little weight on the perturbational studies that support the detected correlations. I wish there was one back and forth btwn editors and authors before posting the reviews.
"The European Commission and Pfizer have agreed a deal to cut the number of Covid-19 vaccines supplied to the EU, resolving tensions between the majority of member states over paying for shots that may not be used."
https://www.ft.com/content/eb4fe823-66bd-4e1a-8b96-13b8f8c3dce9
“Two new studies illuminate the mechanisms for inflammation of brain tissue which is persistent and occurs even in patients with a mild #Covid19 illness. Importantly, these were studies of people with Covid, not specifically individuals who were suffering from Long Covid.”
A new post from @erictopol.
'In physics education research studies I led as a postdoc, I learned that many scientists—particularly those from underrepresented groups—find public engagement helps sustain them through tough times in their careers, just as it did for me. One student shared with me that facilitating the children’s hospital project inspired her to persist in physics; being recognized as an expert by the public helped her overcome a sense that she didn’t belong in academia. I had felt the same.'
Immunologist Akiko Iwasaki: ‘We are not done with Covid, not even close’
27 May 2023
'Researchers who analysed the biomedicine training pathway found that the greatest loss of people from under-represented minorities seems to occur at two points: during undergraduate education, and in the transition from postdoctoral fellowship to tenure-track faculty position'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com