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'Members of the Sackler family who own Purdue Pharma can be shielded from lawsuits linked to the US opioid crisis in exchange for payments worth up to $6bn, appellate judges have ruled in a reversal of a lower court’s decision.'

ft.com/content/823612fb-a365-4

Ian is thoughtful, trustworthy, and a decent coot. “Dr Virology”, who alerted me to SARS2 in January 2020.

From: @mackayim2022
mastodon.social/@mackayim2022/

In Editors' Choice this week in Science Signaling, we highlight the work of Ahn et al. in Cell. They investigated the adaptor protein ASC2 in bat immune cells. ASC forms aggregates in response to viral infection, resulting in inflammatory cytokine production. However, bat ASC2 suppressed this pathway. Mice expressing bat ASC2 had improved responses to viral infections. The findings suggest how bats may serve as viral reservoirs. Read a summary here: science.org/doi/10.1126/scisig #viruses #immunology

When Coltrane was a member of the Miles Davis quintet, Davis confronted him about the duration of his solos "I don't know what it is," Coltrane said. "It seems like when I get going, I just don't know how to stop."
Davis said, "Why don't you try taking the fucking horn out of your mouth?"

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'Indigenous populations are disproportionately affected by COVID-19, but are rarely studied. An investigation of the immune response of Australian First Nations people to SARS-CoV-2 vaccination and infection shows a major effect of comorbidities.'

nature.com/articles/s41590-023

"Basic research is ultimately what gives us the grounding for breakthroughs".

Our Magda Bienko, Group Leader in the #Genomics Research Centre, explains how and why she decided to embrace her research adventure at #HumanTechnopole to understand the architecture of human #DNA.

On @Nature Italy
 
#sciencemastodon #science #lifesciences #humangenome

nature.com/articles/d43978-023

IL6 is not always the bad guy.

"In the penumbrae of human stroke brain lesions, we identified a subpopulation of microglia that express vascular endothelial growth factor A. These cells, termed ‘repair-associated microglia’ (RAMs), were also observed in a rodent model of CVI and coexpressed interleukin (IL)-6Ra. Cerebrovascular repair did not occur in IL-6 knockouts or in mice lacking microglial IL-6Ra expression"

nature.com/articles/s41590-023

Thank you @snsf_ch for providing a Flexibility Grant to cover daycare costs for a postdoc in the lab. #EDI

Seinfeld in Spanish: croissants with knife & fork in Madrid

That revolutionary new fMRI technique for detecting neuronal activity (DIANA)? Guess what happened next.

pubpeer.com/publications/0EF43

bioRxiv preprints "contradictory results" are really useful. And whoever is posting them to PubPeer is perfoming a real public service, because it is difficult for readers to discover them.

'Members of the Sackler family who own Purdue Pharma can be shielded from lawsuits linked to the US opioid crisis in exchange for payments worth up to $6bn, appellate judges have ruled in a reversal of a lower court’s decision.'

ft.com/content/823612fb-a365-4

New posting! This one's about optics, but nothing to do with microscopy - instead it's asking whether we should perhaps view and not knowledge as the real (primary) product of ...and whether this provides a better rationalisation of the level of societal investment. Are research papers actually a by-product?

totalinternalreflectionblog.co

'Indigenous populations are disproportionately affected by COVID-19, but are rarely studied. An investigation of the immune response of Australian First Nations people to SARS-CoV-2 vaccination and infection shows a major effect of comorbidities.'

nature.com/articles/s41590-023

"The European Commission and Pfizer have agreed a deal to cut the number of Covid-19 vaccines supplied to the EU, resolving tensions between the majority of member states over paying for shots that may not be used."

ft.com/content/eb4fe823-66bd-4

"Hundreds of thousands of low-income Americans have lost Medicaid coverage in recent weeks as part of a sprawling unwinding of a pandemic-era policy that prohibited states from removing people from the program."

nytimes.com/2023/05/26/us/poli

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