Thiago Carvalho @cyrilpedia@qoto.org

Two papers from Semantic Web Applications and Tools for Health Care and Life Sciences 2023 #SWAT4HCLS2023 @swat4hcls with Bgee inside:
• Towards predicting essential proteins via federated SPARQL queries https://ceur-ws.org/Vol-3415/paper-45.pdf
• Data in use for Alzheimer disease study: combining gene expression, orthology, bioresource and disease datasets https://ceur-ws.org/Vol-3415/paper-47.pdf
#SIB #SemanticWeb #bioinformatics #GeneExpression

Comparing Kenyon cells between sawflies (ancestral Hymenoptera) and honeybees:

"Evolutionary dynamics of mushroom body Kenyon cell types in hymenopteran brains from multi-functional type to functionally specialized types", Kuwabara et al. 2023 https://www.science.org/doi/10.1126/sciadv.add4201

"the functions in learning and memory of the ancestral KC type were heterogeneously inherited among the KC types in the honey bee."

#neuroscience #Hymenoptera #honeybees #bees #KenyonCells

Hey Mastodon users! This is my first post as I just opened my account migrating from @doctorpoe on twitter. I hope to find my old friends and make new ones among the mastodon conoscenti.

Groundbreaking ceremony for the new building of the Helmholtz Institute for Translational Oncology #HI-TRON in Mainz (Germany), providing a space for novel cutting-edge #immunotherapy development, #personalizedmedicines and #mRNAs as tools in #cancer #research @mainz_de @unimainz @helmholtz @hereon @dkfz
https://www.dkfz.de/de/presse/pressemitteilungen/2023/dkfz-pm-23-33a-HI-TRON-Mainz-ein-Helmholtz-Institut-des-DKFZ-erhaelt-neues-Gebaeude.php

You don't have to use Mastodon through an app!

Every server has its own website where you can log in and use all its features. The web interface is excellent, and it usually gets the latest features before the apps do.

Your server's website address will usually be the same as its name, for example the website for the server kind.social is at https://kind.social

The website works on both computers and phones. (If you're using the phone version, click # to see the search box.)

#FediTips

First U.S. malaria cases diagnosed in decades in Florida and Texas

https://apple.news/AAKEPbESNQ3O6MrncKtzIJg

Looking forward to a great day of talks at the Jacques Monod insect models for infection biology! Thanks to @eLife and all sponsors! #InsInf2023

Random selection from Pastel's #proteomics resources page http://www.pastelbioscience.co.uk/resources/databases.html - = - https://github.com/ByrumLab/ProteoViz | ProteoViz | analysis and visualization of Phosphoproteomics data sets

The trial is for idiopathic pulmonary fibrosis.

'The company said the drug, INS018_055, was the first entirely “AI-discovered and AI designed” drug to begin a phase 2 clinical trial and represented an important milestone for the industry.'
#drugdiscovery #drugdevelopment #artificialintelligence

https://www.ft.com/content/82071cf2-f0da-432b-b815-606d602871fc

Yet another study showing that tumor mutation burden is a poor predictor of response to checkpoint blockade.

"First we assembled the largest pan-cancer dataset of immunotherapy patients with sequencing and clinical data. Surprisingly, we find little evidence that TMB is predictive of response to ICB.
(...)
Our analysis shows that the use of TMB in clinical practice is not supported by available data and can deprive patients of treatment to which they are likely to respond."
#Immunology #immunooncology #immunotherapy

https://elifesciences.org/reviewed-preprints/87465

“It’s stunning,” says the immunologist Barney Graham, the former deputy director of the Vaccine Research Center and a central figure in the development of mRNA vaccines, who has lately been writing about a “new era for vaccinology.” “You cannot imagine what you’re going to see over the next 30 years. The pace of advancement is in an exponential phase right now.”

https://www.nytimes.com/2023/06/23/magazine/golden-age-medicine-biomedical-innovation.html

Postdoctoral Researcher – Ellerby lab

Buck Institute for Research on Aging

#Ellerby lab at #Buck seeks a #Postdoc Scientist experienced in stem cells, neurodegenerative diseases & mouse models.

See the full job description on jobRxiv: https://jobrxiv.org/job/buck-institute-for-research-on-aging-27778-postdoctoral-researcher-ellerby-lab/?feed_id=48495

#ScienceJobs #hiring ...
https://jobrxiv.org/job/buck-institute-for-research-on-aging-27778-postdoctoral-researcher-ellerby-lab/?feed_id=48495

#OTD 26 June 1925 Jean Frydman was born. A French Jew, he became active in the Resistance & even escaped a deportation train to Buchenwald. He was a peace advocate who helped negotiated the Oslo Peace Accords 1993 between Israel & Palestine. He died in 2021 at the age of 95.

Follow @TexasObserver’s coverqge on the larger aftermath of the Dobb ruling, one year later: https://www.texasobserver.org/topics/public-health/

Referenced link: https://www.nature.com/articles/s42255-023-00829-4.epdf
Discuss on https://discu.eu/q/https://www.nature.com/articles/s42255-023-00829-4.epdf

Originally posted by Nature Portfolio / @NaturePortfolio: http://nitter.platypush.tech/NaturePortfolio/status/1673368796319432704#m

Pairing exercise with a diet-induced weight-loss intervention leads to greater improvement in insulin sensitivity and glucose control than dieting alone in people with obesity and prediabetes, according to a clinical trial published in @NatMetabolism. https://www.nature.com/articles/s42255-023-00829-4.epdf

Last year, we failed to replicate some key experimental results in an extraordinary @eLife paper. Our results, the authors' response, and a correction to the original paper are now published.

https://elifesciences.org/articles/84435
https://elifesciences.org/articles/85370
https://elifesciences.org/articles/90007

My opinion is that the original paper is flawed and should be retracted, but now @eLife readers can hear from both sides and decide for themselves.

Watch Footage of Claude Monet Painting in His Famous Garden at Giverny (1915)

https://www.openculture.com/2023/06/watch-footage-of-claude-monet-painting-in-his-famous-garden-at-giverny-1915.html