Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'Virus-based vectors — particularly those based on adeno-associated virus (AAV) and lentiviruses — have dominated the first wave of gene therapies to gain regulatory approval. But their widespread deployment in dozens of clinical trials has exposed their limitations.'
#genetherapy
Thiago Carvalho
boosted
Cada día que pasa queda más clara la impertinencia de la política oficial de la Iglesia española de que "la ropa sucia se lava en casa" cuando cada día que pasa queda más evidente que la suciedad no está en la ropa, está en la casa https://elpais.com/sociedad/2023-06-26/la-iglesia-espanola-se-enfrenta-ya-a-mas-de-1000-acusados-de-pederastia.html
"I love that Odysseus and Achilles are complete disasters as heroes; they made terrible mistakes. They’re incredibly proud and angry. They reign destruction down on the people around them—the people that they love, not just their enemies. Achilles’s name—there are a couple different etymologies for it, but likely it comes from grief to the people. Odysseus’s name is related etymologically to the word that means to be hated."
https://www.publicbooks.org/madeline-miller-on-circe-mythological-realism-and-literary-correctives/
Thiago Carvalho
boosted
Sorting out sorting machinery with proximity proteomics
Beverley Wilson, Chloe Flett, Patrick Caswell, et al. use proximity labelling to investigate the Rab4 and Rab11 recycling pathways and identify new machinery that regulates cancer cell migration.
Highlight: https://journals.biologists.com/jcs/article/136/12/e136_e1202/319489/Sorting-out-sorting-machinery-with-proximity
Article: https://journals.biologists.com/jcs/article/136/12/jcs260468/318453/Proximity-labelling-identifies-pro-migratory
This article is a @ReviewCommons transfer.
You can find out more about Review Commons and the transfer to affiliate journals including @J_Cell_Sci here: https://www.reviewcommons.org/authors/
Thiago Carvalho
boosted
New Nature article looks at how to end misogyny and inequalities in science
#WomenInSTEM #womeninmedicine
#medicalwriters #sciencejournalists #medicaljournalists
Don’t get mad, get equal: putting an end to misogyny in science
Subtle forms of misogyny attack female leadership and coerce women to conform to conventional gender norms. It’s time to call out these behaviours, say Alison Bentley and Rachael Garrett.
Article available at: https://www.nature.com/articles/d41586-023-02101-x
"One of the paramount lessons of the #Covid19 pandemic is that fresh air matters. Although officials were initially reluctant to acknowledge that the coronavirus was airborne, it soon became clear that the virus spread easily through the air indoors. As the pandemic raged on, experts began urging building operators to crank up their ventilation systems and Americans to keep their windows open. The message: A well-ventilated building could be a bulwark against disease."
https://www.nytimes.com/2023/06/17/health/covid-ventilation-air-quality.html
'Quase um terço das famílias que arrendam casa em Portugal estão em situação de sobrecarga financeira, ou seja, são obrigadas a gastar mais de 40% do seu rendimento disponível para suportar os custos com habitação.'
Thiago Carvalho
boosted
Researchers might be willing to take on risky projects if they could be insured against that risk, with wages that didn't depend on the vicissitudes of scientific fortune.
But you can't completely ensure against the failure to get results, because bad luck is indistinguishable from loafing and you need to somehow incentivize effort.
That's a big 'if'
"Artificial intelligence (AI) is often glibly posed as the answer for services that are already forced to do more with less. Yet the idea that intelligent computers could simply replace humans in medicine is a fantasy. AI tends not to work well in the real world. Complexity proves an obstacle. So far, AI technologies have had little impact on the messy, inherently human world of medicine. But what if AI tools were designed specifically for real-world medicine – with all its organisational, scientific, and economic complexity?"
Keep your tacky Salazarist discovery monument - this is the Portuguese institution that matters.
Thiago Carvalho
boosted
'Provision of Signal 2 from DCs to naïve T cells during priming is the second critical step [30], which usually takes the form of DC-expressed CD80 and CD86 interacting with CD28 on T cells. Consistent with this, Cd80−/−Cd86−/− mice have impaired CD8+ T cell responses after Ad5 immunization, but for reasons that remain to be elucidated Cd28−/− mice have a different phenotype: delayed but not fully impaired CD8+ T cell responses'
#Immunology #Vaccine
Thiago Carvalho
boosted
'Intas provided America with a lot of frontline chemotherapy drugs—half of the country’s supply in some cases—that are used to treat more than a dozen types of cancer. When the disastrous inspection led the company to halt production, other manufacturers couldn’t make up the difference.'
Thiago Carvalho
boosted
#Introduction (just moved to new instance)
I am a cell biologist running a research group (@roylelab) focused on membrane traffic and cell division in human cells. My lab is in @Warwick_CMCB at #WarwickUni. My posts are mainly about #science and #CellBiology but also #music, #running and #cycling.
My previous handle was clathrin. For my data analysis alter-ego, follow @quantixed.
#Microscopy #ImageAnalysis #MembraneTraffic #Mitosis #OpenScience #RStats
'We show here that lipid-mediated engagement of invariant natural killer T (iNKT) cells with enterochromaffin (EC) cells, a subset of intestinal epithelial cells, promoted peripheral serotonin (5-HT) release via a CD1d-dependent manner, regulating gut motility and hemostasis.'
#Immunology #MucosalImmunology #Neuroimmunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00236-4
Thiago Carvalho
boosted
#HappyBirthday to Isabelle (Yasmina) Adjani, one of the greatest living French actors, born in Paris #OnThisDay in 1955. Winner of an unprecedented five Cesar acting Awards, she was extraordinary as Stella in Polanski's #TheTenant (1976), Lucy Harker in Herzog's #NosferatuTheVampyre (1979) and the title role in #LaReineMargot (1994). Pictured here in one of modern horror's most astonishing performances, as Sam Neill's fracturing, adulterous wife in Andrzej Zulawski's #Possession (1981).
Of course it was
"The AfD was formed in 2013 by a small group of Eurosceptic economists opposed to bailouts for southern eurozone countries. It gradually shifted its focus to immigration, adopting a stridently xenophobic and anti-Islamic tone, which won it legions of new fans, especially in former communist east Germany."
https://www.ft.com/content/d2eb427f-5e8e-4448-950a-96203e52eb9d
Thiago Carvalho
boosted
'A Matter of Survival: How the WGA Is Trying to Save Feature Screenwriters'
John August and Writers Guild leaders weigh in about the systemic exploitation of feature screenwriters (i.e. free work) and the contract proposals that would help them...and the whole film industry in the process.
Read: https://open.substack.com/pub/colehaddon/p/a-matter-of-survival-how-the-wga?r=1mimd1&utm_campaign=post&utm_medium=web
#WGAstrong #WGAstrike #WGA #screenwriting #screenwriter #film #movies #cinema
'Oncologists are concerned that the alternatives to two crucial chemotherapy drugs are far less effective in treating certain cancers, and are sometimes more toxic. The backup therapies or lack thereof, they say, pose particularly troubling prospects for patients with ovarian, testicular, breast, lung and head and neck cancers.'
Spain is also observing a post pandemic T1D increase in children and teenagers
"El primer estudio hecho en España confirma una tendencia detectada también en otros países: los diagnósticos en menores fueron en 2021 hasta un 60% más de los esperados"
'By the late ’80s, his prospects remained bleak. In 1987, Mr. Erskine retired. In 1989, Mr. McCarthy wrote to a friend, “I’ve been a full-time professional writer for 28 years, and I’ve never received a royalty check. That, I’ll betcha, is a record.”
https://www.nytimes.com/2023/06/19/opinion/cormac-mccarthy-publishing.html
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
