Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
The intracellular Fc receptor strikes again:
"Mechanistic studies revealed that TTCM2-ms cleared intracellular, synaptic, and seed-competent tau aggregates through tripartite motif-containing 21 (TRIM21), an intracellular antibody receptor and E3 ubiquitin ligase known to facilitate proteasomal degradation of cytosolic antibody-bound proteins. TRIM21 was found to be essential for TTCM2-ms–mediated clearance of tau pathology."
https://www.science.org/doi/full/10.1126/scitranslmed.adj5958
Thiago Carvalho
boosted
'With Aeschylus, it’s a happy ending. There’s peace. Orestes is pardoned. But Euripides takes the same plot and writes it in a completely contrary way. Orestes is not pardoned. He and Electra are condemned to death by stoning. They run amok, storm the palace and burn the whole city down. It reminds me a lot of the storming of the U.S. Capitol. We have the dream of Aeschylus and the nightmare of Euripides. It’s like pieces of a puzzle that don’t fit together, and that interests me.'
https://www.nytimes.com/2024/07/13/arts/salzburg-festival-greek-tragedy.html
Thiago Carvalho
boosted
'Japan now counts over a thousand varieties of miso, and each region is synonymous with a local recipe: Edo sweet red miso in Tokyo (the city being previously known as Edo) and sweet white miso in Kyoto. In the Chūkyō region it’s dark brown and bitter; in Kyushu it’s made with barley (mugi). As Kazutoshi Endo, chef-patron of the Michelin-starred London sushi restaurant Endo at the Rotunda, puts it, “miso equals culture”.'
Thiago Carvalho
boosted
Dahlia (of some sort), Botanical Gardens, Copenhagen
Have to love the joyful dahlia blooms in summer; one remarkable year I actually had them bloom in my garden, but the snails and slugs munch them down to nothing every year since then.
#bloomscrolling #dahlia #Botanical #BotanicalGarden #flowers #flower #summer #Photography #pentax #PentaxK70 #PentaxK70_RN
Thiago Carvalho
boosted
From @pluralistic:
“For all that the right has bombed so many of the roads to a prosperous, humane future, it's a huge mistake to think of the right as a stable, unified force, marching to victory after inevitable victory.
“The American right is a brittle coalition led by a handful of plutocrats who have convinced a large number of turkeys to vote for Christmas.”
💯💯
https://pluralistic.net/2024/07/14/fracture-lines/#disassembly-manual
Thiago Carvalho
boosted
#PhysicsFactlet
If you ever studied any Physics in school you probably know that the trajectory of an object thrown in a uniform gravitational field will be a parabola.
But if the drag (e.g. due to the atmosphere) is not negligible, the trajectory will be much more skewed, and it will fall almost vertically after reaching its maximum height.
#Physics #ITeachPhysics
Thiago Carvalho
boosted
Israel’s legalization of settlements in the northern West Bank, explained
'When I was starting my group, I was reading advice on Twitter. A lot wasn't very useful, but somebody asked, ‘What is the single most important advice to a new PI?’ Somebody answered that it was to ‘grow slowly’, and I couldn't agree more. I tried to take the same approach: I will only hire someone in my lab if I'm absolutely sure they'll be a good fit. I think that has worked well so far.'
https://journals.biologists.com/dev/article/150/12/dev202032/319909/Transitions-in-development-an-interview-with
'The SNSF Swiss Postdoctoral Fellowships 2024 call document is already available. The other relevant documents (Instructions for submitting an application via mySNF and the Research Plan Template) will be updated and published by 2 September 2024 when the call for proposals opens.'
https://www.snf.ch/en/m1NtWp4nTELQixlu/funding/horizon-europe-swiss-postdoctoral-fellowships
Thiago Carvalho
boosted
As GLP-1 sales surge, insulin users fear Novo Nordisk and Eli Lilly will move on without them
Thiago Carvalho
boosted
Issue 13 is complete!
Explore our ToC here: https://journals.biologists.com/jcs/issue/137/13
Our cover image shows a bead sprouting assay of HUVECs expressing a constitutively active c-Src mutant (magenta). The cells exhibit irregular blood vessel formation with actin shown in green and DAPI in blue. https://journals.biologists.com/jcs/article/137/13/jcs262101/359780/c-Src-induced-vascular-malformations-require
Also in Issue 13:
- Research Highlights on CEP41, exocytosis, retromer & retriever and c-Src
- Interview with Rob Parton
- Review on lymphocyte activation
- Review on chromosome interlocks
"Concomitant to the unravelling of bacterial immune defence was the realisation that some antiphage systems are in fact conserved in eukaryotes [7–9]. For example, cyclic GMP-AMP synthase (cGAS)-like enzymes, which produce cyclic dinucleotide second messengers upon pathogen detection, and viperins, which generate modified nucleotides blocking viral replication, protect bacteria and humans alike. Contrary to the conceptual framework of clade-specific immune mechanisms, a fraction of immune modules (domains or proteins involved in defence) are conserved between prokaryotes and eukaryotes."
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002717
Thiago Carvalho
boosted
Inarguably the most important human genetics paper of the year, and a landmark moment in the history of neurodevelopmental disorder (NDD) genetics.
Mutations in RNU4-2, encoding a small nuclear RNA (snRNA) are among the most frequent genetic causes of NDD, explaining up to 0.4% of all cases. Yet, these variants have not been found all these years, despite the big advancements in genome sequencing in the past years.
The mind-blowing part: just a region of 18 base pairs that encode a critical part of the snRNA holds all the NDD mutations, a majority of them are insertion mutations. A 18bp noncoding region explaining 0.4% of all NDDs is really huge. This knowledge will solve (already solving) genetic diagnoses of thousands of NDD patients around the world.
The 18-bp region is highly constrained. Natural selection is actively removing the mutations from the population, yet the region keeps mutating again and again and again. The next important follow up will be to find what drives such a high mutation rate in this region, particularly insertion mutations.
The authors add a new twist to the story: the majority of the maternally inherited. This is surprising, as the origins of NDDs are typically paternally biased. The mechanism is going to be absolutely mind-blowing.
Congrats Nicky and team on this remarkable work.
This is one of the biggest success stories of 100k genomes project by Genomics England. Whole genome sequencing is already making a big impact in the rare disease space!
'The Electronic Bard is not easy for Trurl to make. In thinking about how to program it, Trurl reads “twelve thousand tons of the finest poetry” but deems the research insufficient. As he sees it, the program found in the head of even an average poet “was written by the poet’s civilization, and that civilization was in turn programmed by the civilization that preceded it, and so on to the very Dawn of Time.” The complexity of the average poet-machine is daunting.'
https://www.newyorker.com/science/elements/thinking-about-ai-with-stanislaw-lem
Thiago Carvalho
boosted
STAT+: A second Roche obesity drug shows promise in early studies
https://www.statnews.com/2024/07/17/roche-obesity-carmot-ct996/?utm_campaign=rss
Thiago Carvalho
boosted
"In June a notice posted on the website of the journal Nature set a new scientific record. It withdrew what is now the most highly cited research paper ever to be retracted."
HT Retraction Watch
#PublicationEthics #NatureMagazine #SpringerNature #ScientificAmerican #ResearchIntegrity #Retractions #StemCells #StemCellScience #AdultStemCell #CatherineVerfaillie #UniversityOfMinnesota #BoneMarrow #HighImpact #PeterAldhous
Thiago Carvalho
boosted
STAT+: Data privacy startup raises $30 million, to ease health care providers' regulatory burden
Thiago Carvalho
boosted
i2MassChroQ : full native timsTOF PASEF-enabled quantitative proteomics | https://hal.science/hal-04321638/document
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#proteomics #prot-other
'Women taking the anti-diabetes medication Ozempic might have an extra reason to pat their tummies. Not only does the injectable drug lead to weight loss, a finding that has sparked frenzied off-label demand worldwide, but in recent months it has also been linked to a surprise baby boom.'
https://www.ft.com/content/bf52faa7-9428-450f-a1f6-69fde3fa4c51
Thiago Carvalho
boosted
If... future... hinges on our capacity to create something different... then what... matters is whether we... rediscover the freedoms that make us human in the first place... We are projects of collective self-creation... What if we treat people, from the beginning, as imaginative, intelligent, playful creatures who deserve to be understood as such?
#DawnOfEverything : A New History of Humanity by #DavidGraeber and #DavidWengrow ; Ch 1.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
