Thiago Carvalho @cyrilpedia@qoto.org

“On average, everyone’s weight rapidly returned,” Dr. Cummings said. And, he said, other medical conditions, like elevated blood sugar and lipid levels, return to their previous levels after improving.'

https://www.nytimes.com/2024/08/09/health/ozempic-weight-loss-drugs.html

'Lá fora, Lisboa é referência para absolutamente tudo. Gostam da nossa cultura, da nossa comida, do nosso estilo de vida. Elogiam os preços ‘baratos’, a beleza das nossas cidades e a hospitalidade das nossas pessoas. Mas a realidade vivida na capital é conhecida por aqueles que aqui vivem, viver em Lisboa tornou-se um pesadelo para os Lisboetas e um paraíso para os tourists e os expats.'

https://www.esquerda.net/artigo/moedas-oposicao-contra-os-lisboetas-resposta-de-um-jovem-de-volta-casa/91849?utm_source=dlvr.it&utm_medium=bluesky

'Anakinra inhibited NFκB activation in CLL cells in part by lowering oxidative stress and led to transient tumor regression in patients. However, IFN signaling became up-regulated and was associated with loss of the initial clinical response.'

https://www.pnas.org/doi/10.1073/pnas.2405644121

“Alarm bells went off when Šimkovičová took over the culture portfolio last autumn,” said Albin Sybera, a fellow of the central European policy thinktank Visegrad Insight. “What we saw again last week is that those fears were not unfounded. We are seeing a spreading of radical rightwing positions into Slovakia’s mainstream discourse.”

https://www.theguardian.com/world/article/2024/aug/10/slovakia-purges-heads-of-national-theatre-and-gallery-in-arts-crackdown

'Judicial hostility to labor is hardly a new phenomenon. As Jackson noted in her partial dissent, “To put it bluntly, courts exercising their equitable discretion amidst labor disputes today do so against the backdrop of an ignominious history of abuse.”

https://www.nybooks.com/online/2024/08/10/misjudging-labor/

Today, in Scumbag News

"Doctors, social workers & librarians are among those in Sweden who have sounded the alarm over a proposal being explored by a government-appointed committee that would force public sector workers to report undocumented people to authorities."

https://www.theguardian.com/world/article/2024/aug/11/sweden-snitch-law-immigration-plan-prompts-alarm-across-society

"We can certainly say that this government has a more repressive attitude, and is less open to freedom of information,” said Andrea Di Pietro, a Rome-based media lawyer. “This is a change that we have all perceived . . . They are less willing to accept criticism on a political level.” 
https://www.ft.com/content/a682c564-d122-450e-842f-64fb8f692f64

"We addressed the question of mitochondrial lactate metabolism using genetically-encoded sensors. The organelle was found to contain a dynamic lactate pool that leads to dose- and time-dependent protein lactylation. In neurons, mitochondrial lactate reported blood lactate levels with high fidelity."
#Metabolism #Preprint

https://www.biorxiv.org/content/10.1101/2024.07.19.604361v1

'Scientists have found a solution that experts say comes as close to a cure for type 1 diabetes as any drug therapy could: smart insulin that lies dormant in the body and only springs into action when needed. Researchers in the US, Australia and China have successfully designed novel insulins that mimic the body’s natural response to changing blood sugar levels and respond instantly in real time.'
https://www.theguardian.com/society/article/2024/aug/11/scientists-hail-smart-insulin-responds-changing-blood-sugar-levels-real-time-diabetes

O Pesadelo do Moeda

'In recent years, 150,000 square metres of public space across three of Valencia’s central squares – Plaza del Ayuntamiento, Plaza de la Reina and Plaza del Mercat – have been pedestrianised, with major bus routes and traffic diverted.'

https://www.theguardian.com/travel/article/2024/aug/12/a-greener-spanish-city-break-electric-boats-birds-and-rice-fields-in-valencia

"Here, we review how studies in mice and humans have informed our current framework for understanding energy homeostasis, discuss their challenges and limitations, and offer a perspective on how human studies may play an increasingly important role in the discovery of disease mechanisms and identification of therapeutic targets in the future."

https://www.cell.com/cell/fulltext/S0092-8674(24)00771-2

Etymology:

"Plato was an outstanding wrestler (Plato was a nickname conferred on him by his wrestling coach; it means “broad-shouldered”), and at least three of the Socratic dialogues—Theaetetus, Charmides, Lysis—take place in wrestling rooms (palaestrae)."

https://thepointmag.com/politics/wrestling-in-paris/?ref=thebrowser.com

'But, as with other big issues facing the continent, one sticking point is how much money will be spent on an issue primarily affecting half the bloc. While the north will also face increasingly deadly heat, floods, fires and the spread of communicable disease, the hammer is falling first and hardest in the south.'

https://www.politico.eu/article/kyriakos-mitsonakis-teresa-ribera-ursula-von-der-leyen-europe-south-climate-change/

'Classic cancer genes such as KRAS and TP53 increase cellular plasticity, providing the nonheritable phenotypic variability that drives cancer.
Evolutionary theory predicts that recombination of different developmental plasticity programs often creates the novelty that generates new traits.'
https://www.cell.com/trends/cancer/abstract/S2405-8033(24)00145-6

'It is disorienting at first to see a reference that does not contain a journal title, because this bucks a deeply ingrained practice. But journal names are too often used as a proxy for research excellence or quality. I want people reading my CV to consider what I wrote, not where it was published, which I know is sometimes attributable to luck as much as substance.'
https://www.nature.com/articles/d41586-024-02596-y

“Study finds 94% of business spreadsheets have critical errors”

https://phys.org/news/2024-08-business-spreadsheets-critical-errors.html

this_is_fine.gif 😬

For the small number of people interested in cerebral lateralization, a little analysis showing that we need to measure it in individuals including a confidence interval around the estimate - if you do that, then what looks like bilateral processing turns out to be misleading: most people are lateralized but without bias to left or right.
https://royalsocietypublishing.org/doi/10.1098/rsos.240495
#laterality #brain #language #neuroscience

@cyrilpedia One aspect mentioned is the need to archive research data at the institution. Even though we have this as an official policy at our institute, I find it frustratingly hard to run after team members and get them to archive their raw data post-publication (which is mostly programs and calculations, we are a theory group). Most have to be reminded many many times.

Any thoughts on this? What are your experiences?