Follow
Oooooo, what’s that…mitochondria morphology controls Fatty acid oxidation (FAO). 🤔
Fragmented - CPT1 more active - ⬆️ FAO.
Elongated - CPT1 more sensitive to inhibition - ⬇️ FAO
Does this fit with what we know about Immunometabolism? 🤔🤨🧐
M1 macrophage - fragmented mitochondria - glycolytic
M2 macrophage - elongated mitochondria - FAO
Also opposite to correlation described by Ngo et al. in non immune cells:
https://doi.org/10.15252/embj.2022111901
🤨 something different it’s going on in #Immunometabolism
Any other examples?
Effector CD8 T cells - fragmented mitochondria but glycolytic
Memory CD8 T cells - elongated mitochondria but use FAO and OXPHOS
Opposite way around to mechanism described by NGO et al.
🤔 Food for thought..
Other Immunometabolism examples? Reply..
(From Erika Pearce’s lab)