Oooooo, what’s that…mitochondria morphology controls Fatty acid oxidation (FAO).
Fragmented - CPT1 more active - FAO.
Elongated - CPT1 more sensitive to inhibition - FAO
Does this fit with what we know about Immunometabolism?
M1 macrophage - fragmented mitochondria - glycolytic
M2 macrophage - elongated mitochondria - FAO
Also opposite to correlation described by Ngo et al. in non immune cells:
https://doi.org/10.15252/embj.2022111901
something different it’s going on in #Immunometabolism
Any other examples?