RT @helenaapinheiro
New cover @NatImmunol depicting NK cell-intrinsic sex differences.
O'Sullivan & Maureen Su Labs @UCLA show that an extra copy of the X-linked epigenetic regulator UTX in female mice increases NK cell effector function in female mice.

RT @janeohlmeyer
Signed, sealed, delivered! Our open letter to @SimonHarrisTD with 1800+ signatures was delivered to @DeptofFHed today where we had a very constructive meeting with Minister. Now to next steps @OireachtasNews, let's make Ireland the best place to do research

RT @laoneill111
Excellent discussion with Simon Harris, Minister for Further and Higher Education Research Innovation and Science, as the Irish govt prepares the Research and Innovation Bill 2023- once in a generation chance to set Ireland on the best path for research and innovation support. twitter.com/janeohlmeyer/statu

This study is exciting because it uses a direct intervention, using a recombinant anchored enzyme, to change nutrient levels within a local micro environment.

What enzyme would you like to use therapeutically?

And into what micro environment would you like to anchor it?

/end

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IDO-Gal3 reduces the severity of symptoms in mice with established osteoarthritis.

They also show anti-inflammatory effects in skin inflammation and that IDO-Gal3 averts and inhibits periodontal disease progression. (4/5)

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Using a mechanical overloading osteoarthritis mouse model, mice were treated weekly with intra-articular IDO-Gal3 injections.

You can clearly see the retention of Gal3-IDO in the joint. (3/5)

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