DaveFinlayTCD @finlayd@qoto.org
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
RT @janeohlmeyer
Signed, sealed, delivered! Our open letter to @SimonHarrisTD with 1800+ signatures was delivered to @DeptofFHed today where we had a very constructive meeting with Minister. Now to next steps @OireachtasNews, let's make Ireland the best place to do research #LoveIrishResearch
IDO-Gal3 reduces the severity of symptoms in mice with established osteoarthritis.
They also show anti-inflammatory effects in skin inflammation and that IDO-Gal3 averts and inhibits periodontal disease progression. (4/5)
Using a mechanical overloading osteoarthritis mouse model, mice were treated weekly with intra-articular IDO-Gal3 injections.
You can clearly see the retention of Gal3-IDO in the joint. (3/5)
Key advance:
Generating an IDO-Gal3 fusion protein.
Gal3 binds to fly and in the extracellular matrix (ECM) of tissues, anchoring IDO in place at the site of inflammation - very clever IMHO. (2/5)
Interesting analysis of manuscript retraction data, 2010-12 vs 2017-19:
-Increase in # of retracted papers
-Change in geographical origins.
😬
Data in figures shows groups of urban areas between which at least 2 retracted articles were co-authored.
https://dapp.orvium.io/deposits/6442fee5c93d17c257de17d2/view
Interesting 🤔. A common mechanism, located at the lysosome, linking amino acid and energy stress to organelle biosynthesis.
A few of my favourites in this one: #FNIP1 #AMPK #TFEB #mitochondria #mTORc1
Gut bacteria move into tumours and support immunotherapies by metabolising tryptophan to make indole-3-aldehyde.
More reasons to take care of your gut microbiome.
😬😬 not sure I have any gut bacteria left after 9 weeks iv antibiotics 😬😩
Lots of interest things in this paper but one thing that struck me was that:
"CD44 mediates the endocytosis of specific metals bound to hyaluronate, including copper".
A new transporter it would seem, at least to my knowledge anyway😁
How amazing are my ex PhD students @JesssicaW28 @loftusro @katiezyxw and @KediaMehta, who sent me this feel better soon package.
Including a mug with lab photos across the lifetime of the Finlay lab 🥰 and a lockpicking set - that’s an important skill to have 🤣
Thank you 😊
RT @MitoPsychoBio
How we think and talk about mitochondria matters to our science and to newcomers in the field.
The powerhouse analogy is expired and we need specific vocabulary to capture the beautiful complexity of mitochondrial biology.
We propose a framework and some nomenclature.
RT @laoneill111
Can’t beat statistics…Irish workers are the most productive in the world.
RT @kzernike
A 14-yo girl read The Exceptions and painted this picture as a tribute to Nancy Hopkins and her groundbreaking science. The artist’s mother, also a fan, presented this to Nancy last week.
Here’s to the future.
Don't you just LOVE when a paper comes out providing an explanation for a long term lab question 😀🎉 Mystery solved!!
This really nice paper just out in #PLOSpathogens
by @FirpoMason and @bryancmounce based at the Loyola University Chicago @LoyolaInDIRI. (a🧵)
Our Question?
RT @RyanLab_MBU
🚨Last weeks #immunometabolism discoveries🚨 @Bims_BiomedNews ⬇️⬇️⬇️
http://biomed.news/bims-imicid/2023-04-23
Highlights:
I) MYC-SLC7A5-glycolysis metabolic axis regulates MAIT cell proliferation & is impaired in obesity
II) Hypusination regulates SREBP2 translation & enterovirus infection
RT @UMassMetNet
Had a wonderful day with guest "Fluxing Star" Evanna Mills (sporting a MetNet T-shirt!) who's seminar on how metabolites function as signaling molecules was outstanding! Learn about Evanna and her amazing ability to hold a plank at the Metabolog - https://www.umassmed.edu/metnet/blog/2023/04/evanna-mills/
CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor
RT @AndyHogan82
Delighted to see our latest paper out in @scisignal - led by @KediaMehta & Marta Pisarska with superstar collaborator @LindaVSinclair - we go deeper on #MAITcell metabolism and the impact of obesity - https://www.science.org/doi/10.1126/scisignal.abo2709
RT @MiriamMerad
Excited to share our new paper in @NatImmunol on how TREM2+ monocyte-derived macrophages in lung cancer reduce activity of natural killer cells that fight tumors. We provide potential dual targeting strategies to improve antitumor immunity. Read here: https://rdcu.be/damS8
RT @McLoughlin_Lab
Fantastic research on show today @tcdTBSI for our annual celebration of Postgraduate research @tcdbi Congratulations to Roisin Lynch from @EdLavellee lab this years winner of the Tipton medal for postgraduate research also Erika Stewart from @TJRyan_77 lab a worthy runner up.
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
