Effector CD8 T cells - fragmented mitochondria but glycolytic

Memory CD8 T cells - elongated mitochondria but use FAO and OXPHOS

Opposite way around to mechanism described by NGO et al.

🤔 Food for thought..

Other Immunometabolism examples? Reply..

(From Erika Pearce’s lab)

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Oooooo, what’s that…mitochondria morphology controls Fatty acid oxidation (FAO). 🤔

Fragmented - CPT1 more active - ⬆️ FAO.

Elongated - CPT1 more sensitive to inhibition - ⬇️ FAO

Does this fit with what we know about Immunometabolism? 🤔🤨🧐


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This intro is brilliant - but the whole piece is so smart and so thoughtful too.

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Dear @GaryLineker
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The theory of quaternions was born when a sudden thought came to William Rowan Hamilton as he was walking with his wife along the Royal Canal in Dublin, Ireland. It was the fundamental formula:

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RT @VikiLovesFACS
We now have data on the safety of in from *nine* countries (thanks Romania!) 🇷🇴

👩🏻‍🔬 36 studies

🤰🏿 Including more than 364,068 ppl vaccinated in pregnancy

...find no increased risk of pregnancy problems.



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Trinity has taken key steps to improve for researchers, including consolidating the University’s three internal schemes and increasing their associated to €25,000.
Read more here: tcd.ie/news_events/top-stories

Delighted to see this. So much respect for you and all you do to communicate the data based evidence regarding the Covid vaccines and pregnancy. 💪👩‍🔬
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Viki Male (2004) returned to college to receive the alumna of the year award - set up to recognise individual contributions to society.
During the pandemic, Viki ensured pregnant people could access evidence-based information on the C…

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Professor Doreen Cantrell has been named the British recipient of the Feldberg Prize 2023 from the Feldberg Foundation. This annual award to given to a scientist who is deemed outstanding in their particular field.

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🏴󠁧󠁢󠁳󠁣󠁴󠁿 1,574 babies exposed to infection before 20 weeks of , compared to 4,722 uninfected controls

👉🏻 No increased risk of congenital anomalies associated with infection


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🏴󠁧󠁢󠁳󠁣󠁴󠁿 6,731 exposed to before 20 weeks of , vs 20,193 controls

👉🏻 No increased risk of congenital anomalies

👉🏻 Including when analysis was restricted to vaccination in the vulnerable window before 10 weeks of pregnancy



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Professor Cliona O'Farrelly has today been named a 2022 @aaas Fellow. Cliona has been honoured for her outstanding achievements as a researcher in the field of comparative immunology.

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It's been a great week on the @ERC_Research front with two Trinity researchers winning Proof of Concept Grants and another two winning Consolidator Grants!

Congratulations everyone 🎉

👉 bit.ly/3Ht3EhY
👉 bit.ly/40ehZGm

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Exciting news for the school this morning with the announcement of @SDoyleTcd's award from the @ERC_Research for her ground-breaking investigations for novel immunotherapies to fight blindness. Congratulations Sarah! Read more about Sarah's research here: bit.ly/3JBdQGm

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📢 Looking for a Postdoctoral Fellow to join the team!
Translational project to identify early molecular signatures which might predict onset of
Deadline: 31st Jan 2023.
RT appreciated

RT @ImmPRes_
did you notice that in the last release we added a feature to study protein families. For example, how about looking at the glycolytic proteins and how they change upon T cell activation in CD8s?

Easily done in the heatmap section 😎

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