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RT @Irishimmunology
We are very excited to announce that Prof @EdLavellee is to be awarded our Annual Award for Immunology 2022 for his contributions to Irish immunology research and education!

For more information about the award you can check out our website at irishimmunology.ie/annual-awar

We are here now too. What to do next? Please follow mstdn.science/@CytokineSociety. The ICIS is the premier organization promoting the field of cytokine biology across many different research disciplines at a time when cytokine biology, cytokine biomarkers and cytokine therapeutics are revolutionizing modern medicine, providing novel treatments for a wide variety of diseases ranging from lethal inflammatory, autoimmune and allergic diseases, to viral infections and cancer.

RT @lydfinley
Do you ❤️ the TCA cycle? (trick question). Our new review discusses the origins, discovery, and many functions of the mammalian TCA cycle. By @paigearnold2 @SKI_CellBiology out now in @jbiolchem jbc.org/article/S0021-9258(22)

RT @FearonCassidy
Our latest story from the @OSheaHoganLab is now in pre-print, I investigated the metabolic requirements for early MAIT cell responses with the help of the amazing @AndyHogan82 team @KediaMehta @RonanBergin @Andrea_W7 twitter.com/osheahoganlab/stat

RT @cggbamford
Final output of the year, in collab w/ @mark_w_robinson @MaynoothUni and led by @gordongreville highlighting that defects in type I IFN signaling might explain why people with liver disease are more vulnerable to SARS2 infection medrxiv.org/content/10.1101/20 funded by @scienceirel

RT @OSheaHoganLab
NEW PRE-PRINT! Cool new story led by @FearonCassidy on what fuels rapid responses like cytotoxicity. biorxiv.org/content/10.1101/20 Mini thread below

RT @DelgoffeLab
Thrilled to kick off the holiday season with a new paper from the lab! Out in @NatImmunol today, we explore an unexpected function of terminally exhausted T cells and their contribution to the immunosuppressive tumor microenvironment. 🧵 1/ nature.com/articles/s41590-022

Sure, they are at it again. Them moonlighting metabolic enzymes!! Soon they will all have second jobs 🤯🤯.

Lactate dehydrogenase A activates Rac1 signalling.

nature.com/articles/s42255-022

RT @AndyHogan82
New mini-review on metabolism - topic in its infancy but one @KediaMehta & myself think will become very important in the future frontiersin.org/articles/10.33

RT @WimGMeijer
Very sharp increase in SARS-CoV-2 levels in Dublin wastewater. As in the previous two years, viral levels peak during the Christmas period.

Data from 24 June 2020 - 14 December 2022

@UCD_SBBS @UCD_Research @IrishWater
@HSELive @nvrlucdireland @hpscireland

RT @stephan_till
Our paper introducing PK Mito Orange (PKMO) has finally been published. It was a great pleasure to work together with @TianyanL on this project. Wonderful collaboration between @ZhixingChen2 and @JakobsLab!

pnas.org/doi/10.1073/pnas.2215

It is hard communicating science when the world no longer values truth.

Nice piece here about how to improve science education to combat misinformation:

“we need to teach people why science deserves their trust”

post.news/article/2J7VEapSIpNW

Some of you may have seen Elon Musk's endorsement of Robert F. Kennedy Jr.'s crazy antivax conspiracy theories today.

Over at post.news, I just posted a long-form piece about this, and about how science education needs to adapt to online disinformation.

Please a look. If you like it, boost it there or here or — if you dare — over on the birdsite.

post.news/article/2J7VEapSIpNW

RT @CerwenkaLab
For the end of 2022: interesting observations by Ming and Ana - microenvironment matters! @jmingeum @MolBiol_Immunol twitter.com/MolBiol_Immunol/st

RT @FrezzaLab
I am incredibly happy to share this work from our lab and @saezlab, and a lot of fantastic collaborators. We hope you enjoy it!

Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression | Nature Communications nature.com/articles/s41467-022

Neutrophils are a real metabolic enigma!! They are packed full of glycogen particles and now it appears that beta oxidation is crucial in getting them to the site of infection. Maybe they save the glycogen as fuel for when they arrive? 🤷‍♂️🧐🤓

nature.com/articles/s42003-022

What a great approach; Nano sheets that do the same job as Lactate Dehydrogenase, consume lactate making pyruvate. I can think of a few more enzymatic activities that I would like in a nanoparticle format. Beyond my skill set though 🤷‍♂️

ncbi.nlm.nih.gov/pmc/articles/

Engineering amino acid metabolism in CAR-T cells

Very interesting approach. We are now regularly seeing metabolic engineering strategies to improve cellular immunotherapies.

ashpublications.org/bloodadvan

Interesting new piece to the Srebp puzzle. Glutaminolysis released ammonia activated Srebp by disrupting scap-insig interaction. This effect of ammonia is blocked by 25-Hydroxycholesterol.
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RT @NatMetabolism
🏆 Best of | CITATIONS
#11

The team led by Deliang Guo (@OhioState) shows that ammonia released from glutaminolysis disrupts the SCAP/Insig association, thus activating SREBP-1 and promoting lipogenesis to suppor…
twitter.com/NatMetabolism/stat

Congratulations Lorraine, very well deserved 😁
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RT @DonnachaOD
Very proud of my brilliant wife Lorraine who was formally inducted into the RIA along with some other luminaries including her good friend and colleague @ProfJohnCrown.
twitter.com/DonnachaOD/status/

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