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DaveFinlayTCD

Delighted to get funding for - moving towards measuring multiple metabolic fluxes in single cells in vivo……cue imposter’s syndrome 😬😬😨.

Thank god for my awesome collaborators @LindaVSinclair @svankasteren
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RT @ERC_Research
We've just announced 90 new Proof of Concept Grants, ending the final round of 2022 competition. This brings to 366 the total number of grantees who received under the ERC last year’s wo…
twitter.com/ERC_Research/statu

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DaveFinlayTCD

Location, location, location!!

Great study by @cris_f_aguiar and @MoraeaPedro showing that the tissue of resistance dictates iNKT cell metabolism, and lots more…..

A must read for all out there.
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RT @cris_f_aguiar
@CellReports had a great timing on putting the paper online the day after my birthday 🎁 Thanks!
We are happy to share our work on iNKT cell metabolism 👇🏼
https://www.cell…
twitter.com/cris_f_aguiar/stat

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DaveFinlayTCD

RT @tcdflow
We're hiring an RA to work with me and Prof. Jean Fletcher ( and translational ) in @tcdTBSI through the COVID-19 Immunology Research Hub. Please spread the word! Deadline Friday week...

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DaveFinlayTCD

RT @CellRepMed
Online now: Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles dlvr.it/ShB4VQ

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DaveFinlayTCD

Lymphatic vessels in the bone marrow!! 🤔

Sure why not. Makes sense now that I think about it 😁

://www.cell.com/cell/fulltext/S0092-8674(22)01574-4#.Y8lvSm_Vxy4.twitter

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DaveFinlayTCD

RT @SNI_NKMeeting
Registration is now open for ! Welcome to the north on September 26-29, we look forward to hosting you in Oslo, Norway and learn and discuss everything new about NK cells! nk2023.org/registration

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DaveFinlayTCD

SIZE MATTERS, when it comes to particulate adjuvants.
Very relevant for vaccine design. Great work by @RossWWard44 from @EdLavellee lab @tcdbi @tcdTBSI
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RT @RossWWard44
Please check out our new paper just published in @CellRepMed - We show that for polymeric particulate adjuvants size matters!
cell.com/cell-reports-medicine

We demonstate the size dependant adjuvanticity of polymeric parti…
twitter.com/RossWWard44/status

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DaveFinlayTCD

Congratulations Lydia 🎉. Super interesting research question.
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RT @TheMarkFdn
Congratulations Lydia Lynch @lynchielydia @harvardmed @BrighamWomens @BrighamEndo bit.ly/3GU2bjj
twitter.com/TheMarkFdn/status/

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DaveFinlayTCD

Jaysus, is there nothing that isn’t for sale!! Buying authorship on research articles 🤬

nature.com/articles/d41586-023

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DaveFinlayTCD

What do your MAITs like to eat?

‘MAITabolism2 – the emerging understanding of MAIT cell metabolism and their role in metabolic disease’ - great review from @KediaMehta and @AndyHogan82
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RT @KediaMehta
The full version of our new review is out now, discussing MAIT cell metabolism and MAIT cells in metabolic diseases. @AndyHogan82 frontiersin.org/articles/10.33
twitter.com/KediaMehta/status/

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DaveFinlayTCD

RT @EJohnWherry
One of the most impressive T cell papers in the past decades. A truly humbling experiment and incredibly important insights into T cell biology. @Masopust_Vezys truly amazing. A must read for all T cell biologist (all immunologists really). nature.com/articles/s41586-022

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DaveFinlayTCD

RT @DrRGJonesLab
T cells are capable of longevity and division at least 5x the normal organism lifespan (of mice). A 10 year mouse experiment ... slow 👏nature.com/articles/s41586-022

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DaveFinlayTCD

RT @OSheaHoganLab
And unopposed marketing goes on. Need a public health obesity act. Happy Easter.

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DaveFinlayTCD

RT @metab_innate
🚨Last weeks findings🚨@Bims_BiomedNews ⬇️⬇️⬇️

biomed.news/bims-imicid/2023-0

My highlights:
I) @DoctorKvoss & @JeffRathmell find T cell impairment in SLE arises from elevated Transferrin receptor & iron uptake @SciImmunology
II) GOT1 & CD8+ T cells @CellReports

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DaveFinlayTCD

Well, that clears that up then 😁.

Excellent explainer of what the “science is getting less disruptive” study DID and DIDN’T show.

Good man yourself Max 👍😁.
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RT @maxdkozlov
I'm the reporter who wrote the news story about the "science is getting less disruptive" @Nature paper.

I've seen some misconceptions floating around about what the paper did and did not show.

A few observations: 🧵

1/12

twitter.com/maxdkozlov/statu…
twitter.com/maxdkozlov/status/

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DaveFinlayTCD boosted
Adrian Liston

Love this imaging from @jldvib@twitter.com! Amazing just how good high-dimensional confocal is getting...

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DaveFinlayTCD

RT @dr_p_g
Heads up! Macrophages influence DC (and their own) metabolism through nitric oxide. A cautionary tale for GM-CSF-derived DC cultures!

Check out the paper by Lucía @luminarrieta and Janet from the Berod lab @luberod

onlinelibrary.wiley.com/doi/10

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DaveFinlayTCD

More insight into how pressure from our immune system shapes the tumours that develop, from Ping-Chi Ho’s lab. @PCHo_Lab
Immunoediting empowers tumours to disarm T cell by imposing metabolic tug-of-war between tumor and infiltrating T cells thus forming the suppressive tumor microenvironment.

cell.com/cell-metabolism/pdf/S

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DaveFinlayTCD

RT @metab_innate
🚨Last weeks discoveries @Bims_BiomedNews ⬇️⬇️⬇️

biomed.news/bims-imicid/2023-0

My highlights:

I) Microbial metabolite harmaline protects systemic inflammation via bile acid-GPR5 signalling
II) Sphingosine synthesis and S1P promote mito fission and trained immunity

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DaveFinlayTCD

Them bugs in our guts are sooo important. Must think more about how to support the good ones.

Microbial metabolite harmaline protects against virus-induced systemic inflammation.

nature.com/articles/s41564-022

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