Layer 6 corticothalamic neurons induce high gamma oscillations through cortico-cortical and cortico-thalamo-cortical pathways https://www.biorxiv.org/content/10.1101/2024.10.05.616808v1 #neuroscience

**hkl** · Oct 07, 2024, 19:51 *

hkl boosted

**Albert Cardona** @albertcardona@mathstodon.xyz · Oct 07, 2024, 19:51 *

Oct 07, 2024, 19:51 *

Albert Cardona @albertcardona@mathstodon.xyz

Turns out the postsynaptic densities (PSD) that we use in electron microscopy to identify synapses aren’t made of large protein aggregates but rather of specialised cellular organelles:

“we combined mouse genetics and cryo-electron tomography to determine the 3D molecular architecture of fresh isolated and anatomically intact synapses in the adult forebrain. The native glutamatergic synapse did not consistently show a high density of proteins at the postsynaptic membrane thought to be characteristic of the PSD. Instead, a ‘synaptoplasm’ consisting of cytoskeletal elements, macromolecular complexes and membrane-bound organelles extended throughout the pre- and post-synaptic compartments.”

Excellent work by Julia Peukes et al. 2024 https://elifesciences.org/reviewed-preprints/100335

#neuroscience #synapses #CryoEM #CryoCLEM

**hkl** · Oct 08, 2024, 04:40

hkl boosted

**Peter Gleick** @petergleick@fediscience.org · Oct 08, 2024, 04:40

Oct 08, 2024, 04:40

Peter Gleick @petergleick@fediscience.org

A few climate change cartoons for you.
Any resemblance to the scientist behind the lectern is purely coincidental.

**hkl** @hkl@qoto.org · Oct 07, 2024, 00:14

**hkl** @hkl@qoto.org · Oct 07, 2024, 00:14

Oct 07, 2024, 00:14

hkl @hkl@qoto.org

@bibliolater I'm having the same issue too. I thought it was because I've been inactive for a bit. Do we know when this will be fixed?

**hkl** · Jun 18, 2024, 06:57

hkl boosted

**The vOICe vision BCI 😎🧠** @seeingwithsound@mas.to · Jun 18, 2024, 06:57

Jun 18, 2024, 06:57

The vOICe vision BCI 😎🧠 @seeingwithsound@mas.to

#Ultrasound system for precise #neuromodulation of human deep brain circuits https://www.biorxiv.org/content/10.1101/2024.06.08.597305v1 "we demonstrate the system's ability to selectively modulate the activity of the lateral geniculate nucleus (#LGN) and its functionally connected regions in the visual cortex" #neuroscience

More information in the Twitter/X thread https://x.com/UCL_Ultrasound/status/1799718513655120318

**hkl** · Feb 04, 2024, 13:08

hkl boosted

**Bibliolater 📚📜🖋** @bibliolater@qoto.org · Feb 04, 2024, 13:08

Feb 04, 2024, 13:08

Bibliolater 📚📜🖋 @bibliolater@qoto.org

"It is a puzzle why humans tend toward unrealistic optimism, as it can lead to excessively risky behavior and a failure to take precautionary action. Using data from a large nationally representative U.K. sample (N=36, 312) our claim is that optimism bias is partly a consequence of low cognition—as measured by a broad range of cognitive skills, including memory, verbal fluency, fluid reasoning and numerical reasoning."

Dawson, C. (2023). Looking on the (B)right Side of Life: Cognitive Ability and Miscalibrated Financial Expectations. Personality and Social Psychology Bulletin, 0(0). https://doi.org/10.1177/01461672231209400 #OpenAccess #OA #Research #Article #DOI #Human #Psychology #Optimism #Cognitive #DecisionMaking #Academia #Academic #Academics @psychology

06b091a27d2d2430.jpeg

**hkl** · Jan 30, 2024, 22:15

hkl boosted

**The vOICe vision BCI 😎🧠** @seeingwithsound@mas.to · Jan 30, 2024, 22:15

Jan 30, 2024, 22:15

The vOICe vision BCI 😎🧠 @seeingwithsound@mas.to

#All_Aboard for iOS: #AI-based app uses a smartphone's camera to guide the blind to bus stops https://newatlas.com/good-thinking/all-aboard-app-blind-bus-stops/ YouTube video at https://www.youtube.com/watch?v=VUVpqEw1_2k Sounds like a bomb will go off any second?

**hkl** · Feb 03, 2024, 08:22

hkl boosted

**The vOICe vision BCI 😎🧠** @seeingwithsound@mas.to · Feb 03, 2024, 08:22

Feb 03, 2024, 08:22

The vOICe vision BCI 😎🧠 @seeingwithsound@mas.to

#Neuralink has put its first chip in a human brain. What could possibly go wrong? https://theconversation.com/neuralink-has-put-its-first-chip-in-a-human-brain-what-could-possibly-go-wrong-222497 #BCI #NeuroTech #NeuroEthics

**hkl** · Jan 28, 2024, 13:56

hkl boosted

**Earl K. Miller** @ekmiller@fediscience.org · Jan 28, 2024, 13:56

Jan 28, 2024, 13:56

Earl K. Miller @ekmiller@fediscience.org

Beyond hippocampus: Thalamic and prefrontal contributions to an evolving memory
https://doi.org/10.1016/j.neuron.2023.12.021
#Neuroscience

**hkl** · Jan 28, 2024, 14:27

hkl boosted

**Bibliolater 📚📜🖋** @bibliolater@qoto.org · Jan 28, 2024, 14:27

Jan 28, 2024, 14:27

Bibliolater 📚📜🖋 @bibliolater@qoto.org

"In this technical report, we demonstrate a single scenario where a Large Language Model acts misaligned and strategically deceives its users without being instructed to act in this manner," https://www.livescience.com/technology/artificial-intelligence/chatgpt-will-lie-cheat-and-use-insider-trading-when-under-pressure-to-make-money-research-shows #AI #ArtificialIntelligence #LLM #Tech #Technology #STEM #Science @science

**hkl** · Jan 25, 2024, 13:47

hkl boosted

**Moritz Negwer** @moritz_negwer@mstdn.science · Jan 25, 2024, 13:47

Jan 25, 2024, 13:47

Moritz Negwer @moritz_negwer@mstdn.science

Histone Serotonylation is one of the crazier epigenetic modifications - #Serotonin, the neurotransmitter, is shuttled into the nucleus and coupled to specific glutamine residues on the histone tails.

This happens not only in the brain, but apparently also in the placenta, this new paper shows:

Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome
Chan et al., J Mol B 2024
https://doi.org/10.1016/j.jmb.2024.168454

#epigenetics #histone