Gaspar Jekely @jekely@qoto.org
- Platynereis connectome
- https://catmaid.jekelylab.ex.ac.uk
Professor at Centre for Organismal Studies (COS), University of Heidelberg, Germany
and
Living Systems Institute (LSI), University of Exeter, UK.
#neuroscience of marine larvae, #connectomics, #cilia, ciliary swimming, cell and nervous system #evolution, #GPCR, #neuropeptides, #Platynereis, #Trichoplax, #Nematostella, #Schistosoma, #coral #neuroscience #rstat #evolution
Joined Nov 2022
For this paper, all analyses, plots, code, figures, text and references were made in R (with some analyses in #Fiji)
and are all available on #github
https://github.com/JekelyLab/Bezares_et_al_2023_Pressure
you can clone the entire repo and open the .rproj R project
#rstats #openscience
10/9+1
Currently we are trying to understand what underlies the extreme sensitivity of the ciliary photoreceptors to pressure Stay tuned.
9/9
We propose a model for a pressure gauge in zooplankton, including ciliary photoreceptos as sensors and a circuit linking these to the ciliary band cells, leading to increased beating through the action of serotonin, driving faster upward swimming.
8/9
By #connectome analysis, we previously showed that the ciliary photoreceptors synaptically connect through interneurons to the head serotonergic ciliomotor neurons (Ser-h1). Serotonin increases ciliary beating and genetic inhibition of these cells blocked the effect of pressure on cilia, confirming that the pressure signal reaches the ciliated cells via the mapped circuit.
#connectomics
7/9
To identify the #neuronal mechanisms, Luis carried out #calcium #imaging experiments and found that the brain ciliary #photoreceptor cells showed graded activation by pressure stimuli.
4/9
Luis Bezares, the first author of the study, built custom pressure chambers where he could precisely control pressure levels while imaging the swimming activity of the #larvae.
Larvae showed graded and adaptable responses to relative changes in pressure. Increased pressure led to faster beating of locomotor cilia.
The larvae were extremely sensitive to pressure changes, reacting already to 10-20 mbar increase in pressure, corresponding to 10-20 cm water depth.
3/9
Hydrostatic pressure is a dominant cue in the sea and many aquatic organisms are known to respond to changes in pressure, however the neuronal mechanisms have remained unclear.
We studied the larvae of the marine #annelid #Platynereis and found that they respond to increases in pressure by increased upward swimming.
#neuroscience
2/9
We published a new preprint on the mechanism of hydrostatic pressure sensation in marine #zooplankton.
https://www.biorxiv.org/content/10.1101/2023.02.28.530398v1?ct=ct
Click on the toot to see a thread about our findings. 1/9
Gaspar Jekely
boosted
Exciting talk by @Pawel_Burkhardt from @MSarsCentre today in our #Gönomix seminar series (Feb 2, 2.15 pm CET). "The ancestry of the synaptic toolkit and appearance of first neurons" Hybrid format. DM me for the Zoom link.
The full version of our desmosomal #connectome paper is now out, with all videos, supplements, source data nicely integrated
https://elifesciences.org/articles/71231#content
#neuroscience #annelid #microscopy
Gaspar Jekely
boosted
Talk by Gaspar Jekely
@jekely today at 2:15 p.m. (CET) at Uni Göttingen and online.
Gaspar Jekely
boosted
Gaspar Jekely @jekely will be giving this weeks GönomiX talk in Caspari Haus (GZMB) at Uni Göttingen.
Title: Light- and mechanosensory ciliary photoreceptors in the annelid brain and evolution of sensory cell types.
On Thursday 26 Jan at 2:15 p.m. (CET).
The talk will be hybrid. Join us in person or on Zoom using code 962 6989 8358.
Looking forward to having @jekely here!
Gaspar Jekely
boosted
This whole essay is so damn good that it was hard to pick a pull-quote.
"This is enshittification: surpluses are first directed to users; then, once they're locked in, surpluses go to suppliers; then once they're locked in, the surplus is handed to shareholders and the platform becomes a useless pile of shit."
Gaspar Jekely
boosted
Exciting symposium to celebrate 10th anniversary of the IGFL
– free registration and programme at https://igfl10.sciencesconf.org
Gaspar Jekely
boosted
How does the genome orchestrate the development of mulicellular organisms? Which mutations are causing disease?
I'm a scientist at the German Cancer Research Center in Heidelberg. To answer such questions we develop tools for #CRISPR genome engineering. Our main system is the fruit fly #Drosophila.
While we mostly focus on inactivating genes, we sometimes also 'tag' genes to make their products visible. Such as in the pic below.
Gaspar Jekely
boosted
Once in a lifetime - how often did you publish 2 papers in the same journal back to back? I had to grow 50 to do so. Fly sarcomeres go super-resolution: nanobodies + DNA PAINT. Fantastic collaboration with the Jungmann lab in Munich and the Görlich lab in Göttingen. Congrats to @LoreauVincent @FSchueder @PierreMangeol @eunicechyChan @MPI_Biochem @mpi_nat
https://elifesciences.org/articles/79343
https://elifesciences.org/articles/79344
- Platynereis connectome
- https://catmaid.jekelylab.ex.ac.uk
Professor at Centre for Organismal Studies (COS), University of Heidelberg, Germany
and
Living Systems Institute (LSI), University of Exeter, UK.
#neuroscience of marine larvae, #connectomics, #cilia, ciliary swimming, cell and nervous system #evolution, #GPCR, #neuropeptides, #Platynereis, #Trichoplax, #Nematostella, #Schistosoma, #coral #neuroscience #rstat #evolution
Joined Nov 2022
