Jeffrey C. Erlich

@UlrikeHahn @faelif

E.g. if you are flipping a fair coin then p(h)=p(t) = 0.5 (k==2). The probability of observing some specific sequence htththhthtis just 0.5^m where here m = 10.

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Jeffrey C. Erlich

@faelif @UlrikeHahn

the probability of observing a single specific sequence is (1/k)^m.

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Jeffrey C. Erlich

@albertcardona hey, I'm waiting for you to assign me the eLife paper, so I can start to get reviewers!

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Jeffrey C. Erlich boosted
Sainsbury Wellcome Centre

“You can’t just be confident, you have to be confident about something.”

Research led by @jerlich and Xiaoyue Zhu in @nbdt_journal set out to disentangle the different kinds of confidence by designing a perceptual gambling task for rodents.

⬇️

sainsburywellcome.org/web/blog

Diagram of the perceptual gambling task. Rats need to report whether a tone is lower or higher than 8KHz. On some trials a flash on the right (or left) indicates that correct responses to the side of the flash will result in a higher reward. But errors are never rewarded. Credit - Jeff Erlich.
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Jeffrey C. Erlich boosted
Alex Holcombe

Elsevier/RELX profit rises 10%, investor call: "continuing to see strong growth" including from pay-to-read and pay-to-publish. From the www.journalology.com newsletter.

In my opinion, more researchers and universities need to stop supporting them. One way to help is to join the Free Journal Network fediscience.org/@alexh/1140556

Elsevier parent company reports 10% rise in profit, to £3.2bn Relx, the parent company of academic publishing giant Elsevier, has reported a 10 per cent underlying growth in its adjusted operating profit for 2024, reaching just under £3.2 billion from revenues of £9.43bn. Within this, the scientific, technical and medical arm of the company—which includes its publishing business—had an adjusted operating profit of £1.17bn, with underlying growth of five per cent. This arm had revenue of £3.05bn, giving it an adjusted operating margin of 38.4 per cent, the company reported on 13 February. Research Professional News (Craig Nicholson)
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Jeffrey C. Erlich boosted
Aki Vehtari

If you know simulation based calibration checking (SBC), you will enjoy our new paper "Posterior SBC: Simulation-Based Calibration Checking Conditional on Data" with Teemu Säilynoja, @marvinschmitt.com and @paulbuerkner.com
arxiv.org/abs/2502.03279 1/5

Title: Posterior SBC: Simulation-Based Calibration Checking Conditional on Data Authors: Teemu Säilynoja, Marvin Schmitt, Paul Bürkner, Aki Vehtari Abstract: Simulation-based calibration checking (SBC) refers to the validation of an inference algorithm and model implementation through repeated inference on data simulated from a generative model. In the original and commonly used approach, the generative model uses parameters drawn from the prior, and thus the approach is testing whether the inference works for simulated data generated with parameter values plausible under that prior. This approach is natural and desirable when we want to test whether the inference works for a wide range of datasets we might observe. However, after observing data, we are interested in answering whether the inference works conditional on that particular data. In this paper, we propose posterior SBC and demonstrate how it can be used to validate the inference conditionally on observed data. We illustrate the utility of posterior SBC in three case studies: (1) A simple multilevel model; (2) a model that is governed by differential equations; and (3) a joint integrative neuroscience model which is approximated via amortized Bayesian inference with neural networks.
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Jeffrey C. Erlich boosted
Sainsbury Wellcome Centre

New SWC research identifies the precise brain mechanisms that enable animals to overcome instinctive fears.

Full story ➡️ sainsburywellcome.org/web/rese

Read the full paper in Science from Sara Mederos, Patty Blakely, @NicoleVissers Claudia Clopath and Sonja Hofer. ➡️ science.org/doi/10.1126/scienc

Coronal brain slice showing projections from different visual areas in the cerebral cortex to the ventrolateral geniculate nucleus (vLGN). These pathways are part of the circuit identified as mediating the suppression of instinctive fear responses.
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Jeffrey C. Erlich

@adredish @pluralistic since online shopping is already dynamic it makes sense for stores to match. Probably you put items in your cart by scanning the QR code with your phone so that’s the price you get.

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Jeffrey C. Erlich boosted
Redish Lab

@pluralistic

How does that "individual pricing in grocery stores" work? Does that mean the price can change from the time you take it off the shelf to the time you check out? How does that match the "economic agreement"? (which depends on full information on both sides).

At least airplane and online store prices lock in the individual price when you select it. It doesn't suddenly change at the payment page. Although, I'm sure that's the next enshitification step...

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Jeffrey C. Erlich boosted
Earl K. Miller

A hardy and hale "huzzah!" to Emery N. Brown on receiving the National Medal of Science! It’s the nation’s highest honor for scientists and engineers.
picower.mit.edu/news/emery-n-b
#neuroscience

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Jeffrey C. Erlich boosted
eLife

A computational #NeuralNetwork model leverages a simple unsupervised learning principle to account for recent findings on when memories move apart (differentiate) or together (integrate) in the brain. #Neuroscience elifesciences.org/articles/886

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Jeffrey C. Erlich boosted
Earl K. Miller

Faces will melt. #sfn2024 #SfN24
reggieslive.com/show/pavlovs-d

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Jeffrey C. Erlich boosted
jonny (good kind)

It took me ~a year to translate Neurodata Without Borders to linkml+pydantic with full abstraction over array/storage backend. Now that I did that, it is taking me ~hours to make interfaces to put NWB in SQL dbs, web APIs for editing and serving NWB datasets (where you can download arbitrary slices of the individual datasets instead of a bigass 100GB HDF5 file), and interconversion between hdf5, dask, and zarr.

Anyway open data in neuroscience is about to get real good.

#neuroscience #linkml #OpenData #OpenScience

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Jeffrey C. Erlich

Come visit out poster Tuesday Oct 8 Morning!

LBA008.033 / LBA119 -
Task Context Shapes Short-Term Memory Localisation

Go see our very exciting results demonstrating the sensitivity of working memory strategies to task context. We made two variations of a classic 2AFC memory-guided orienting task : one that encouraged an egocentric strategy and one that encouraged an allocentric strategy. The results shocked us! M2 only involved in egocentric planning!

abstractsonline.com/pp8/#!/204

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Jeffrey C. Erlich boosted
Sainsbury Wellcome Centre

Applications now open! Join the SWC PhD Programme 2025

🧠 World-class training in systems neuroscience
💰 Fully-funded 4-year programme
💂 Based in London with close links to @GatsbyUCL

Learn more and apply by 11 Nov: sainsburywellcome.org/web/cont

#PhD #Neuroscience

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Jeffrey C. Erlich

@ekmiller Well, we showed the rat SC is causally involved in abstract categorisation, so... not so surprised nature.com/articles/s41593-021 (cited as Ref 51)

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Jeffrey C. Erlich

@Sheril revisionist history (Malcolm Gladwell). All the freakonomics podcasts

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Jeffrey C. Erlich

Excited to share a new paper from the lab:

Encoding of 2D Self-Centered Plans and World-Centered Positions in the Rat Frontal Orienting Field

Activity in the M2 predicts upcoming choices. But what does the activity represent? A gaze-centered plan? A world-centered goal? A specific movement? We asked rats to plan responses to different targets from different start position to find out!

Liujunli Li, Timo Flesch, Ce Ma, Jingjie Li, Yizhou Chen, Hung-Tu Chen and Jeffrey C. Erlich
Journal of Neuroscience 11 September 2024, 44 (37) e0018242024; doi.org/10.1523/JNEUROSCI.0018

Tweetthread: x.com/erlichlab/status/1835716

Encoding of 2D Self-Centered Plans and World-Centered Positions in the Rat Frontal Orienting Field

The neural mechanisms of motor planning have been extensively studied in rodents. Preparatory activity in the frontal cortex predicts upcoming choice, but limitations of typical tasks have made it challenging to determine whether the spatial information is in a self-centered direction reference frame or a world-centered position reference frame. Here, we trained male rats to make delayed visually guided orienting movements to six different directions, with four different target positions for each direction, which allowed us to disentangle direction versus position tuning in neural activity. We recorded single unit activity from the rat frontal orienting field (FOF) in the secondary motor cortex, a region involved in planning orienting movements. Population analyses revealed that the FOF encodes two separate 2D maps of space. First, a 2D map of the planned and ongoing movement in a self-centered direction reference frame. Second, a 2D map of the animal’s current position on the port wall in a world-centered reference frame. Thus, preparatory activity in the FOF represents self-centered upcoming movement directions, but FOF neurons multiplex both self- and world-reference frame variables at the level of single neurons. Neural network model comparison supports the view that despite the presence of world-centered representations, the FOF receives the target information as self-centered input and generates self-centered planning signals.

doi.org
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Jeffrey C. Erlich

@raineyday @JeremyMallin Also Rosetta stone does this. It uses pictures.

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Jeffrey C. Erlich

@david1 huh? Biden won the 2020 election. That doesn't mean people want him to run again now.

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