jonmoulton @jonmoulton@qoto.org

Maintenance of pluripotency-like signature in the entire ectoderm leads to neural crest stem cell potential. https://www.nature.com/articles/s41467-023-41384-6 #Morpholino

Exon 44 skipping in Duchenne muscular dystrophy: NS-089/NCNP-02, a dual-targeting antisense oligonucleotide. https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00252-4 #Morpholino

Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit. https://elifesciences.org/reviewed-preprints/91258 #Morpholino

Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression. https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00237-8 #Morpholino

SASH1 contributes to glial cell migration in the early development of the central nervous system. https://www.sciencedirect.com/science/article/abs/pii/S0012160623001604 #Morpholino

No more #Morpholino tweets for the rest of this week. I am headed for the NIH Research Festival in Bethesda.

Myosin1G promotes Nodal signaling to control Zebrafish Left-Right asymmetry. https://www.biorxiv.org/content/10.1101/2023.09.15.557992v1 #Morpholino

Transposable elements drive the evolution of metazoan zinc finger genes. https://genome.cshlp.org/content/early/2023/09/15/gr.277966.123 #Morpholino

Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation. https://www.mdpi.com/2073-4409/12/18/2285 #Morpholino

Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain. https://www.nature.com/articles/s41598-023-41240-z #Morpholino

Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence. https://elifesciences.org/articles/58300 #Morpholino

β-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the Developing Xenopus Thalamus. https://www.mdpi.com/1422-0067/24/17/13593 #Morpholino

Toxic effects of exogenous retinoic acid on the neurodevelopment of zebrafish (Danio rerio) embryos. https://www.sciencedirect.com/science/article/abs/pii/S0892036223001411 #Morpholino

Alternative splicing of its 5' UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies. https://ashpublications.org/blood/article/doi/10.1182/blood.2023020400/497824/Alternative-splicing-of-its-5-UTR-limits-CD20-mRNA #Morpholino

An ancient pan-cnidarian microRNA regulates stinging capsule biogenesis in Nematostella vectensis. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01083-5 #Morpholino

Actomyosin remodeling regulates biomineral formation, growth and morphology during eukaryote skeletogenesis. https://elifesciences.org/reviewed-preprints/89080 #Morpholino

Inhibition of the serine protease HtrA1 by SerpinE2 suggests a role for an extracellular proteolytic pathway in the control of neural crest migration. https://www.biorxiv.org/content/10.1101/2023.09.05.556243v1 #Morpholino

Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1α in Xenopus. https://www.cell.com/developmental-cell/pdf/S1534-5807(23)00411-2.pdf #Morpholino

(student presentation): Exploring How Splice Site Silencing Impacts Gene Transcription (second abstract, Simrah Bawa) https://www.bu.edu/lernet/grow/participants/abstracts2023.html (video) https://youtu.be/irJxcOJMHLg #Morpholino

Live imaging studies reveal how microclots and the associated inflammatory response enhance cancer cell extravasation. https://journals.biologists.com/jcs/article/doi/10.1242/jcs.261225/327618/Live-imaging-studies-reveal-how-microclots-and-the #Morpholino