A few observations:
Mastodon: Hard to install, very resource intensive, very opinionated (i.e. over asinine things like character limits).
Pleroma: Poor usability. More functional.
Misskey: Sort of okay. It has some interesting features and the usability looks alright? The way it handles visibility is different than other systems leading to unpredictable results.
I have to look deeper into this implementation.
Every time I hear of them, it has to do with, ironically, complaining about NSFW content on the fediverse (is it really that surprising that someone will use it for this?).
I also have potential concerns about language / cultural barriers here.
@olives What about Firefish? It's a fork of Misskey/Calckey, and no language barriers from what I see.