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@AmpBenzScientist First there should be a cure for sleep deprivation!

@trinsec It depends on how severe it is. Modafinil has an odd effect that allegedly makes sleep more efficient but I'm not sure that it's completely true. A stimulant like amphetamine is outclassed except for Traumatic Brain Injuries. Amphetamine is linked to better outcomes for Traumatic Brain Injuries which is incredible if it can be used.

Sleep still mocks humanity. Partial sleep would barely be good enough for the brain. The muscles and body would suffer. So it's going to be an unfathomable amount of drugs for mediocre performance or just sleeping.

Not sleeping for over 2 days is highly questionable. At 24 hours there's an excessive amount of dopamine released that has been researched for depression treatment. This is essentially all that can be gained. The physical fatigue becomes apparent rather quickly, caloric intake is absurd and hypertrophy is going to be difficult.

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